Decreased occipital lobe metabolism by FDG-PET/CT: An anti–NMDA receptor encephalitis biomarker

John C. Probasco; Lilja Solnes; Abhinav Nalluri; Jesse Cohen; Krystyna M. Jones; Elcin Zan; Mehrbod S. Javadi; Arun Venkatesan

doi:10.1212/NXI.0000000000000413

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Figure 1 Patients with acute anti–NMDA receptor encephalitis have marked hypometabolism of the visual cortical brain region correlating with the medial occipital lobes
Initial brain fluorodeoxyglucose (FDG)-PET/CT of 8 patients with anti–NMDA receptor, studied within 12 weeks of symptoms. Composite of hypometabolism three-dimensional sterotactic surface projections (3D-SSP): indigo least abnormal and red most abnormal. FLAIR = fluid-attenuated inversion recovery.
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Figure 2 Medial occipital lobe (designated by visual cortical brain regions) hypometabolism in anti–NMDA receptor encephalitis
(A) Boxplots of Z scores for fluorodeoxyglucose (FDG)-avidity for brain regions on dedicated FDG-PET/CT for patients admitted after presenting with 12 weeks or less of symptoms with anti–NMDA receptor and other definite AE. (B) Boxplots of Z scores for FDG-avidity for brain regions on initial dedicated brain FDG-PET/CT for all patients with anti–NMDA receptor encephalitis grouped by the modified Rankin Scale (mRS) at the time of the FDG-PET/CT study. AE = autoimmune encephalitis.

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Decreased occipital lobe metabolism by FDG-PET/CT

An anti–NMDA receptor encephalitis biomarker

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