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January 01, 2018; 5 (1) ArticleOpen Access

Disease activity following pregnancy-related discontinuation of natalizumab in MS

Iris Kleerekooper, Zoé L.E. van Kempen, Cyra E. Leurs, Iris Dekker, Theo Rispens, Birgit I. Lissenberg-Witte, Caspar E.P. van Munster, Brigit A. de Jong, Bob W. van Oosten, Bernard M.J. Uitdehaag, Mike P. Wattjes and Joep Killestein
First published December 6, 2017, DOI: https://doi.org/10.1212/NXI.0000000000000424
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    Figure Clinical and radiologic disease activity and confirmed disability progression across the 3 groups defined by time to conception

    (A) Relapses refer to the total number of reported relapses; no patient experienced more than 2 relapses. (B) MRI activity refers to active T2 hyperintense and/or contrast-enhanced T1 hyperintense lesions on the first MRI after DMT restart compared with the last MRI before NTZ discontinuation. (C) Confirmed disability progression defined as an increase in the EDSS score of 1.5, 1.0, or 0.5 point at DMT restart compared with the EDSS score of 0, 0.5–5.5, or >5.5 before NTZ discontinuation, respectively. DMT = disease-modifying treatment; EDSS = Expanded Disability Status Scale; NTZ = natalizumab.

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