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June 2014; 1 (1) ArticleOpen Access

Outcome in patients with bacterial meningitis presenting with a minimal Glasgow Coma Scale score

Marjolein J. Lucas, Matthijs C. Brouwer, Arie van der Ende, Diederik van de Beek
First published May 15, 2014, DOI: https://doi.org/10.1212/NXI.0000000000000009
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Article Information

vol. 1 no. 1 e9
DOI: 
https://doi.org/10.1212/NXI.0000000000000009
PubMed: 
25340065
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Online ISSN: 
2332-7812
History: 
  • Received February 10, 2014
  • Accepted in final form April 3, 2014
  • First Published May 15, 2014.
Copyright & Usage: 
© 2014 American Academy of Neurology This is an open access article distributed under the terms of the Creative Commons Attribution-Noncommercial No Derivative 3.0 License, which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially.

Author Disclosures

    1. Marjolein J. Lucas, MD,
    2. Matthijs C. Brouwer, MD, PhD,
    3. Arie van der Ende, PhD and
    4. Diederik van de Beek, MD, PhD
  1. Marjolein J. Lucas, MD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Matthijs C. Brouwer, MD, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) Dutch Scientific Organization [NWO], Veni Grant nr 916.130.78, 2012

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) European Federation of Neurological Sciences, Scientific fellowship grant, 2011; (2) European Society of Clinical Microbiology and Infectious Diseases, Research Grant, 2011

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Arie van der Ende, PhD and
    4. Scientific Advisory Boards:

    1. Served on the scientific advisory boards for GSK (2011 and 2012) and Pfizer (2011 and 2012)

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Diederik van de Beek, MD, PhD
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. BMC Infectious Diseases, Associate Editor, 2008-now Cochrane Acute Respiratory Infections Group, Editor, 2002-now

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Omeros. Research grant on complement inhibition in meningitis.

    Research Support, Government Entities:

    1. Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL). Analysis of exonic variants in patients with bacterial meningitis (principle investigator: period, 2011-2012). European Research Council (ERC). ERC Starting Grant. Nationwide prospective study on community-acquired bacterial meningitis: from genetics to therapy (principle investigator: period, 2011-2016). ERC FP-7. The genetic basis of meningococcal and other life threatening bacterial infections of childhood (part as principle investigator: 2011-2014 [principle investigator: Prof. Levin, London]). ZonMW Vidi. Host and pathogen genetics in bacterial meningitis (principle investigator: 2011-2015).NWO TOP. Sepsis associated delirium: mechanisms, interventions and outcome (co-principle investigator: 2010-2013). ZonMw Costs and effectiveness. Randomized controlled trial on antibiotic prophylaxis with ceftriaxone to prevent infections in patients with stroke (co-principle investigator: 2009-2012).

    Research Support, Academic Entities:

    1. The Academic Medical Center (AMC Fellowship 2008; principle investigator: period, 2008-2013).

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Departments of Neurology (M.J.L., M.C.B., D.v.d.B.) and Medical Microbiology (A.v.d.E.) and the Netherlands Reference Laboratory for Bacterial Meningitis (A.v.d.E.), Academic Medical Center, Center of Infection and Immunity Amsterdam (CINIMA), Amsterdam, the Netherlands.
  1. Correspondence to Dr. van de Beek: d.vandebeek{at}amc.uva.nl
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