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Neurology Neuroimmunology & Neuroinflammation
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August 2014; 1 (2) EditorialOpen Access

Remyelination therapy goes to trial for multiple sclerosis

Pedro Brugarolas, Brian Popko
First published August 27, 2014, DOI: https://doi.org/10.1212/NXI.0000000000000026
Pedro Brugarolas
From the Department of Neurology, The University of Chicago, Chicago, IL.
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Brian Popko
From the Department of Neurology, The University of Chicago, Chicago, IL.
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Remyelination therapy goes to trial for multiple sclerosis
Pedro Brugarolas, Brian Popko
Neurol Neuroimmunol Neuroinflamm Aug 2014, 1 (2) e26; DOI: 10.1212/NXI.0000000000000026

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With a number of new drugs approved, the last decade has seen tremendous progress in the treatment of multiple sclerosis (MS). All current drugs work by decreasing inflammation through modulation of the immune system, and while they have been very efficient in reducing the rate of relapses, their impact on the chronic disease course is unknown. A current thought in the MS therapeutics community is that drugs that enhance remyelination may be more effective in reducing long-term disability. This hypothesis is based on the observation that disability in MS increases with age as the capacity of oligodendrocytes to remyelinate decreases.1 Additional support for this hypothesis comes from extensive preclinical studies showing that promoting remyelination either by transplanting myelinating stem cells2,3 or by pharmacologic enhancement of endogenous myelination processes reduces clinical severity in animal models of MS.4,5 In this issue of Neurology® Neuroimmunology & Neuroinflammation, Tran et al.6 take this possibility to its exciting next step by reporting the results of the phase I clinical trial of the first drug aimed at promoting myelin repair.

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  • Go to Neurology.org/nn for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the editorial. The Article Processing Charge for this editorial was waived at the discretion of the Editor.

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  • © 2014 American Academy of Neurology

This is an open access article distributed under the terms of the Creative Commons Attribution-Noncommercial No Derivative 3.0 License, which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially.

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