Multiple Sclerosis Followed by Neuromyelitis Optica Spectrum Disorder
From the National Multiple Sclerosis Society Case Conference Proceedings
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Article Information
- Received June 21, 2022
- Accepted in final form August 12, 2022
- First Published October 21, 2022.
Author Disclosures
- Carolyn Goldschmidt, MD,
- Steven L. Galetta,
- Robert P. Lisak, MD,
- Laura J. Balcer, MD,
- Andrew Hellman, PhD,
- Michael K. Racke, MD,
- Amy E. Lovett-Racke, PhD,
- Roberto Cruz, MD,
- Matthew S. Parsons, PhD,
- Neda Sattarnezhad, MD,
- Lawrence Steinman, MD,
- Scott S. Zamvil, MD, PhD,
- Elliot M. Frohman, MD, PhD and
- Teresa C. Frohman, MPAS, PA-C
- Carolyn Goldschmidt, MD,
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I have served as a consultant for EMD Serono, Genentech and Novartis
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National MS Society grant funding to support neuroimmunology fellowship
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- Steven L. Galetta,
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(1) Neurology, Editorial Board; (2) Journal of Neuro-ophthalmology, Editorial Board
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- Robert P. Lisak, MD,
1) Advisory Board Commercial: Argenx, Mallinckrodt, Takeda, Alivant, ANI, MedDay, Horizon 2) Advisory Board non-profit: National Multiple Sclerosis Society, Michigan Chapter, Clinical Advisory Committee; Myasthenia Gravis Foundation of America, Clinical Advisory Committee; Guillain-Barre Syndrome/CIDP Foundation, International, Global Medical Advisory Commmittee
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Section Editor for Neuroimmunology, Clinical Neuropharmacology, 2005-present; Editorial Board, Immunology Research, 1986-2021; Neuroimmunology Reports 2020-present
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International Neurology: A Clinical Approach, Blackwell, Oxford, 2009; 2017 (2nd edition) Neuroimmunology, Oxford University Press, 2019
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GLG Consulting; Insight Consulting; Alpha Sites Consulting; Argenx; Clearview Consulting, Guidepoint Consulting; Jupiter Consulting; Dedham, Triangle Insights, Horizon Pharmaceuticals, ALI, Alivar and ACTHar Gel, Takeda consulting on autoimmune neurologic disorders, Janssen consulting on S1P receptor modulators
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Health Advisory Committee; National Multiple Sclerosis Society, Michigan Chapter, Board of Governors; Research Grants Committee and Centers of Excellence Committee of the Medical Advisory Committee of the GBS/CIDP Foundation, International; Grants Committee of the Myasthenia Gravis Foundation of America ended-2020
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Alexion; Genentech, Novartis, Medimmune; Chugai, UCB/Ra Pharmaceuticals, Argenx, Takeda paid to Wayne State University for my participation in clinical trials MedDay as Chair of Adjudication Committee for study of biotin in progressive forms of MS
NINDS; 1R21NS118227-01; PI; 7/15/2020-06/30/2022
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- Laura J. Balcer, MD,
Editor in Chief, Journal of Neuro-Ophthalmology, receive payments from the North American Neuro-Ophthalmology Society
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Journal of Neuro-Ophthalmology, Editor-in-Chief, 2019-present
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NIH
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- Andrew Hellman, PhD,
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Quest Diagnostics, Medical Writer, 9 years
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Spouse received NIGMS, R35 GM124766, PI, 2017-2022
Spouse: Fred Hutch Cancer Center Spouse: University of Washington
Spouse: Rita Allen Foundation--Scholar's Grant
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- Michael K. Racke, MD,
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Journal of Neuroimmunology, Editor-in-Chief, 2010-2020
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Quest Diagnostics, Medical Director for Neurology, 2 years
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Salary from Quest Diagnostics
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Stock options from Quest Diagnostics
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- Amy E. Lovett-Racke, PhD,
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Journal of Immunology - Section Editor 2019-resent Brain, Behavior, and Immunity - Editorial Board 2014- present Frontiers in Multiple Sclerosis and Neuroimmunology - Associate Editor 2010-present Journal of Neuroimmunology - Deputy Editor 2010-2020
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1. NIH, R01AI140741, Principle Investigator, 2019-2023 2. NIH, R01AI152435, Principle Investigator, 2020-2025 3. NIH, R01AG059711, Co-Investigator, 2018-2023 4. NIH, R01AI153829, Co-Investigator, 2021-2026 5. NIH and Nationwide Childrens Hospital, 700249-0322-00, Co-Investigator, 2021-2026
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1. Quest Diagnostics (Husband) 2019-present
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- Roberto Cruz, MD,
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- Matthew S. Parsons, PhD,
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K01 Award to Matthew Sidney Parsons from the National Institutes of Health’s Office of the Director (K01OD031900).
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- Neda Sattarnezhad, MD,
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Dr Sattarnezhad has received Sylvia Lawry Physician Fellowship Award from National MS Society.
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- Lawrence Steinman, MD,
Novartis, Atreca, Bristol Myers Squibb, 180LS, TG Therapeutics, Atara Bio, Pasithea
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Novartis, Atara Bio
MS Journal, Proceedings National Academy of Sciences
I have multiple patents on antigen specific tolerance.
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Commercial Novartis, Atreca, Tolerion, Teva, AbbVie, Bristol Myers Squibb, Gossamer, 180LS, TG Therapeutics, Atara Bio
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Atara Bio, Novartis
NIH 2U01AI101984-06 Cooperative Study Group for Autoimmune Disease Prevention (U01)
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Stock options and board membership in Atreca Board of Directors BioAtla, Pasithea, 180 LS
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Tolerion
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Tolerion, Atreca, Adaptive
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- Scott S. Zamvil, MD, PhD,
Dr. Zamvil has received honoraria for serving on Data Safety Monitoring Boards for MS trials conducted by Opexa, BioMS, Teva Pharmaceuticals, Inc. and Eli Lilly and Co. Foundation.
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(1) Biogen - Speaker honoraria and advisory board meetings (2) Teva - Speaker honoraria and advisory board meetings (3) Alexion - Speaker honoraria and advisory board meetings (4) Novartis - Speaker honoraria and advisory board meetings
(1) Neurology, Neuroimmunology and Neuroinflammation, Deputy Editor, 2014-present
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SSZ has served as a consultant to Biogen Idec, Teva Neuroscience, EMD-Serono, Genzyme, Novartis and Roche.
Advanced Health Media, 2009-present Biogen, 2009-present Alexion, 2019-present Viela Bio, 2020
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(1) Biogen - speaker and advisory board meetings (2) Teva - speaker and advisory board meetings (3) Genentech - advisory board meeting (4) Novartis - advisory board meetings (5) Genzyme - advisory board meetings (6) Alexion - advisory board meeting
NIH RO1 AI131624-O1A1 NIH R21 NS10815990-01
NMSS RG 1701-26628 NMSS RG 1801-2986
Alexander M. and June L. Maisin Foundation, PI
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- Elliot M. Frohman, MD, PhD and
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Genzyme-Speaker fees Novartis-Speaker fees Alexion-Speaker fees Janssen-Speaker fees
J of Neurology-Editorial Board Frontiers in Neurology-Editorial Board J of the Neurological Sciences-Editorial Board Neuroimmunology Reports-Editorial Board
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1. Up To Date: i). Internuclear ophthalmoparesis ii). Multiple Sclerosis: Symptom management 2) Cambridge University Press Optical Coherence Tomography in Neurological Diseases
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Genzyme Novartis Alexion Janssen
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National MS Society
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- Teresa C. Frohman, MPAS, PA-C
spouse:Genzyme, Alexion, Novartis, JANSSEN- speaking and consulting
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Spouse: Genzyme, Alexion, Novartis
self and spouse: Editor Neurology Reports Contributor: Up To Date NMSS Fellows Webinar Case Conference Proceedings
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Self: Up-To-Date Spouse: Up-To-Date
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Spouse: Genzyme, Alexion, Novartis, Janssen
Spouse:Genzyme, Alexion, Novartis, Janssen
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- From the Mellen Center for Multiple Sclerosis Treatment and Research (C.G.), Cleveland Clinic, OH; Departments of Neurology (S.L.G., L.J.B.), Population Health (L.J.B.) and Ophthalmology (L.J.B., S.L.G.), New York University Grossman School of Medicine; Department of Neurology (R.P.L.), Wayne State University, Detroit MI; Quest Diagnostics (A.H., M.K.R.), Secaucus, NJ; Department of Microbial Infection and Immunity (A.E.L.-R.), Department of Neuroscience Ohio State University Wexner Medical Center, Columbus; Department of Neurology (R.C.), Doctors Hospital at Renaissance; Department of Neurology (R.C.), University of Texas Rio Grande Valley; Division of Microbiology and Immunology (M.S.P.), Yerkes National Primate Research Center, and Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA; Department of Neurology (N.S., L.S.), Stanford University School of Medicine, Palo Alto, CA; Department of Neurology and Program in Immunology (S.S.Z.), University of California San Francisco; and Distinguished Senior Fellows (Sabbatical) Neuroimmunology Laboratory of Professor Lawrence Steinman (E.M.F., T.C.F.), Stanford University School of Medicine, Palo Alto, CA.
- Correspondence
Dr. Frohman elliot.frohman{at}austin.utexas.edu
Article usage
Letters: Rapid online correspondence
- Author Response: Multiple Sclerosis Followed by Neuromyelitis Optica Spectrum Disorder
- Teresa C. Frohman, Author, Distinguished Senior Fellows (Sabbatical) Neuroimmunology Laboratory of Professor Lawrence Steinman, Stanford University School
- Steven L. Galetta, MD, Author, Departments of Neurology and Ophthalmology, New York University Grossman School of Medicine, New York, NY
- Robert Lisak, MD, Author, Department of Neurology, Wayne State University, Detroit MI
- Laura J. Balcer, MD, MSCE, Author, Departments of Neurology, Population Health, and Ophthalmology, New York University Grossman School of Medicine, New York, NY
- Michael K. Racke, MD, Author, Quest Diagnostics, 500 Plaza Drive, Secaucus, NJ
- Lawrence Steinman, MD, Author, Department of Neurology, Stanford University School of Medicine, Palo Alto, CA
- Scott S. Zamvil, Author, Department of Neurology and Program in Immunology, University of California San Francisco, San Francisco, California
- Elliot M. Frohman, Author, Distinguished Senior Fellows (Sabbatical) Neuroimmunology Laboratory of Professor Lawrence Steinman, Stanford University School
Submitted December 02, 2022 - Multiple Sclerosis Followed by Neuromyelitis Optica Spectrum Disorder
- robert laureno, neurologist, Georgetown University
Submitted November 29, 2022
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