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January 2023; 10 (1) Research ArticleOpen Access

Effect of Estimated Blood Volume and Body Mass Index on GFAP and NfL Levels in the Serum and CSF of Patients With Multiple Sclerosis

Yavor Yalachkov, Jan Hendrik Schäfer, Jasmin Jakob, Lucie Friedauer, Falk Steffen, Stefan Bittner, Christian Foerch, Martin Alexander Schaller-Paule
First published October 31, 2022, DOI: https://doi.org/10.1212/NXI.0000000000200045
Yavor Yalachkov
From the Department of Neurology (Y.Y., J.H.S., L.F., C.F., M.A.S.-P.), University Hospital Frankfurt; and Department of Neurology (J.J., F.S., S.B.), Universitätsmedizin Mainz, Germany.
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Jan Hendrik Schäfer
From the Department of Neurology (Y.Y., J.H.S., L.F., C.F., M.A.S.-P.), University Hospital Frankfurt; and Department of Neurology (J.J., F.S., S.B.), Universitätsmedizin Mainz, Germany.
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Jasmin Jakob
From the Department of Neurology (Y.Y., J.H.S., L.F., C.F., M.A.S.-P.), University Hospital Frankfurt; and Department of Neurology (J.J., F.S., S.B.), Universitätsmedizin Mainz, Germany.
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Lucie Friedauer
From the Department of Neurology (Y.Y., J.H.S., L.F., C.F., M.A.S.-P.), University Hospital Frankfurt; and Department of Neurology (J.J., F.S., S.B.), Universitätsmedizin Mainz, Germany.
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Falk Steffen
From the Department of Neurology (Y.Y., J.H.S., L.F., C.F., M.A.S.-P.), University Hospital Frankfurt; and Department of Neurology (J.J., F.S., S.B.), Universitätsmedizin Mainz, Germany.
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Stefan Bittner
From the Department of Neurology (Y.Y., J.H.S., L.F., C.F., M.A.S.-P.), University Hospital Frankfurt; and Department of Neurology (J.J., F.S., S.B.), Universitätsmedizin Mainz, Germany.
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Christian Foerch
From the Department of Neurology (Y.Y., J.H.S., L.F., C.F., M.A.S.-P.), University Hospital Frankfurt; and Department of Neurology (J.J., F.S., S.B.), Universitätsmedizin Mainz, Germany.
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Martin Alexander Schaller-Paule
From the Department of Neurology (Y.Y., J.H.S., L.F., C.F., M.A.S.-P.), University Hospital Frankfurt; and Department of Neurology (J.J., F.S., S.B.), Universitätsmedizin Mainz, Germany.
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Effect of Estimated Blood Volume and Body Mass Index on GFAP and NfL Levels in the Serum and CSF of Patients With Multiple Sclerosis
Yavor Yalachkov, Jan Hendrik Schäfer, Jasmin Jakob, Lucie Friedauer, Falk Steffen, Stefan Bittner, Christian Foerch, Martin Alexander Schaller-Paule
Neurol Neuroimmunol Neuroinflamm Jan 2023, 10 (1) e200045; DOI: 10.1212/NXI.0000000000200045

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    Figure Serum GFAP (r = −0.220, p = 0.028) and Serum NfL (r = −0.275, p = 0.006) Were Inversely Correlated With the Estimated Blood Volume

    A, B. Serum GFAP (r = -0.220, p = 0.028) and serum NfL (r = -0.275, p = 0.006) were inversely correlated with the estimated blood volume (BV). C, D. No significant correlations were detected between BV and CSF GFAP/NfL. To ensure that the results are not biased, extreme outliers were removed. GFAP = glial fibrillary protein; NfL = neurofilament light chain.

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