Abstract
Myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) is a recently described CNS inflammatory disorder that may manifest with optic neuritis, myelitis, seizures, and/or acute disseminated encephalomyelitis. While MOG-specific antibodies in patients with MOGAD are IgG1, a T-cell–dependent antibody isotype, immunologic mechanisms of this disease are not fully understood. Thymic hyperplasia can be associated with certain autoimmune diseases. In this report we describe a case of MOGAD associated with thymic hyperplasia in a young adult.
Glossary
- Ab=
- antibody;
- AQP4=
- aquaporin 4 antibody;
- CRION=
- chronic relapsing inflammatory ON;
- CRP=
- C-reactive protein;
- ED=
- emergency department;
- ESR=
- erythrocyte sedimentation rate;
- FLAIR=
- fluid-attenuated inversion recovery;
- IgG=
- immunoglobulin G;
- IV-MP=
- IV methylprednisolone;
- MOG=
- myelin oligodendrocyte glycoprotein;
- MOGAD=
- MOG antibody–associated disease;
- NMOSD=
- neuromyelitis optica spectrum disorders;
- NMO=
- neuromyelitis optica;
- ON=
- optic neuritis;
- TLH=
- thymic lymphocytic hyperplasia
Footnotes
Go to Neurology.org/NN for full disclosures. Funding information is provided at the end of the article.
Submitted and externally peer reviewed. The handling editor was Josep O. Dalmau, MD, PhD, FAAN.
- Received September 28, 2022.
- Accepted in final form October 26, 2022.
- Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
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