Research Article

• Open Access

  Risk HLA Variants Affect the T-Cell Repertoire in Multiple Sclerosis

  Melissa Sorosina, Silvia Santoro, Laura Ferrè, Elisabetta Mascia, Ferdinando Clarelli, Antonino Giordano, Miryam Cannizzaro, Moiola Lucia, Vittorio Martinelli, Massimo Filippi, Federica Esposito

  • Abstract
  • Full Text
  • Full Text (PDF)
• Open Access

  Neurologic Manifestations of Common Variable ImmunodeficiencyImpact on Quality of Life

  Bruno Ivo De Almeida, Tammy L. Smith, Alen Delic, Lawanda Esquibel, Jonathan Galli, Leah Millsap, M. Mateo Paz Soldán, Melissa M. Cortez, John Rose, John E. Greenlee, Adi V. Gundlapalli, Harry R. Hill, Ka-Ho Wong, Stacey L. Clardy

  • Abstract
  • Full Text
  • Full Text (PDF)
• Open Access

  Occurrence and Severity of Coronavirus Disease 2019 Are Associated With Clinical Disability Worsening in Patients With Multiple Sclerosis

  Gertjan Peeters, Ann Van Remoortel, Guy Nagels, Jeroen Van Schependom, Miguel D'haeseleer

  • Abstract
  • Full Text
  • Full Text (PDF)
• Open Access

  Immune Profiling Reveals the T-Cell Effect of Ocrelizumab in Early Relapsing-Remitting Multiple Sclerosis

  Alexandra Garcia, Emilie Dugast, Sita Shah, Jérémy Morille, Christine Lebrun-Frenay, Eric Thouvenot, Jérôme De Sèze, Emmanuelle Le Page, Sandra Vukusic, Aude Maurousset, Eric Berger, Olivier Casez, Pierre Labauge, Aurélie Ruet, Catarina Raposo, Fabien Bakdache, Régine Buffels, Fabienne Le Frère, Arnaud Nicot, Sandrine Wiertlewski, Pierre-Antoine Gourraud, Laureline Berthelot, David Laplaud

  • Abstract
  • Full Text
  • Full Text (PDF)
• Open Access

  Autocrine TNF-α Increases Penetration of Myelin-Associated Glycoprotein Antibodies Across the Blood-Nerve Barrier in Anti-MAG Neuropathy

  Ryota Sato, Fumitaka Shimizu, Motoi Kuwahara, Yoichi Mizukami, Kenji Watanabe, Toshihiko Maeda, Yasuteru Sano, Yukio Takeshita, Michiaki Koga, Susumu Kusunoki, Takashi Kanda

  • Abstract
  • Full Text
  • Full Text (PDF)
• Open Access

  Levels of Soluble Interleukin 6 Receptor and Asp358Ala Are Associated With Cognitive Performance and Alzheimer Disease Biomarkers

  Daniel Quillen, Timothy M. Hughes, Suzanne Craft, Timothy Howard, Thomas Register, Cynthia Suerken, Gregory A. Hawkins, Carol Milligan

  • Abstract
  • Full Text
  • Full Text (PDF)
• Open Access

  Antibodies Against Glutamic Acid Decarboxylase 65 Are Locally Produced in the CSF and Arise During Affinity Maturation

  Michelle Biljecki, Katharina Eisenhut, Eduardo Beltrán, Stephan Winklmeier, Simone Mader, Anna Thaller, Peter Eichhorn, Philipp Steininger, Andrea Flierl-Hecht, Jan Lewerenz, Tania Kümpfel, Martin Kerschensteiner, Edgar Meinl, Franziska S. Thaler

  • Abstract
  • Full Text
  • Full Text (PDF)
• Open Access

  Visually Evoked Potential as Prognostic Biomarker for Neuroaxonal Damage in Multiple Sclerosis From a Multicenter Longitudinal Cohort

  Frederike Cosima Oertel, Julia Krämer, Seyedamirhosein Motamedi, Azeen Keihani, Hanna G. Zimmermann, Nikolaos G. Dimitriou, Shivany Condor-Montes, Charlotte Bereuter, Christian Cordano, Ahmed Abdelhak, Anand Trip, Orhan Aktas, Sven G. Meuth, Heinz Wiendl, Klemens Ruprecht, Judith Bellmann-Strobl, Friedemann Paul, Axel Petzold, Alexander U. Brandt, Philipp Albrecht, Ari J. Green

  • Abstract
  • Full Text
  • Full Text (PDF)
• Open Access

  Inflammatory Activity After Diverse Fertility TreatmentsA Multicenter Analysis in the Modern Multiple Sclerosis Treatment Era

  Edith L. Graham, Jennifer B. Bakkensen, Annika Anderson, Nicola Lancki, Anne Davidson, Gina Perez Giraldo, Emily S. Jungheim, Anna C. Vanderhoff, Bridget Ostrem, Evelyn Mok-Lin, David Huang, Carolyn J. Bevan, Dina Jacobs, Tamara B. Kaplan, Maria K. Houtchens, Riley Bove

  • Abstract
  • Full Text
  • Full Text (PDF)
• Open Access

  Retrospective Pediatric Cohort Study Validates NEOS Score and Demonstrates Applicability in Children With Anti-NMDAR Encephalitis

  Marc Nikolaus, Philipp Rausch, Kevin Rostásy, Annikki Bertolini, Ronny Wickström, Jessika Johannsen, Jonas Denecke, Markus Breu, Mareike Schimmel, Katharina Diepold, Martin Haeusler, Annegret Quade, Andrea Berger, Hendrik Rosewich, Claudia Steen, Katja von Au, Mona Dreesmann, Carsten Finke, Frederik Bartels, Angela M. Kaindl, Markus Schuelke, Ellen Knierim

  • Abstract
  • Full Text
  • Full Text (PDF)
• Open Access

  Increased NLRP3 Inflammasome Activation and Pyroptosis in Patients With Multiple Sclerosis With Fingolimod Treatment Failure

  Sunny Malhotra, Laura Hurtado-Navarro, Agustin Pappolla, Luisa M. M. Villar, Jordi Río, Xavier Montalban, Pablo Pelegrin, Manuel Comabella

  • Abstract
  • Full Text
  • Full Text (PDF)
• Open Access

  New Insights on DR and DQ Human Leukocyte Antigens in Anti-LGI1 Encephalitis

  Yahel Segal‬‏, Michal Nisnboym, Keren Regev, Karni Arnon, Hadar Kolb, Firas Fahoum, Orna Aizenstein, Yael Paran, Yoram Louzoun, Sapir Israeli, Ron Loewenthal, Nina Svetlitzky, Yifat Alcalay, Itay Raphael, Avi Gadoth

  • Abstract
  • Full Text
  • Full Text (PDF)