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May 2023; 10 (3) Research ArticleOpen Access

Inflammatory Activity After Diverse Fertility Treatments

A Multicenter Analysis in the Modern Multiple Sclerosis Treatment Era

Edith L. Graham, Jennifer B. Bakkensen, Annika Anderson, Nicola Lancki, Anne Davidson, Gina Perez Giraldo, Emily S. Jungheim, Anna C. Vanderhoff, Bridget Ostrem, Evelyn Mok-Lin, David Huang, Carolyn J. Bevan, Dina Jacobs, Tamara B. Kaplan, Maria K. Houtchens, Riley Bove
First published March 15, 2023, DOI: https://doi.org/10.1212/NXI.0000000000200106
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Article Figures & Data

Figures

  • Figure 1
    Figure 1 Overview of Common Fertility Treatments, Organized Based on Hypothetical Risk of MS Inflammatory Activity

    MS = multiple sclerosis.

  • Figure 2
    Figure 2 Annualized Relapse Rate 3 Months Post-COS vs 12 Months Pre-COS for All Cycles (n = 80)

    COS = controlled ovarian stimulation.

  • Figure 3
    Figure 3 Annualized Relapse Rate 3 Months Post-COS vs 12 Months Pre-COS

    Forest plot shows incidence rate ratio (IRR) overall and by subgroups. If IRR <1, rate of relapse was lower 3 months after FT. If IRR >1, rate is higher 3 months after FT. If IRR is 1, or close to 1, no difference. IRR was unable to be calculated for the following due to no relapses in these groups: age 37 years or older (n = 32), Black or Hispanic (n = 8), disease duration ≥2 years (n = 32), and patients on therapeutic DMT (n = 34). COS = controlled ovarian stimulation; FTs = fertility treatments.

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