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February 2015; 2 (1) Views & ReviewsOpen Access

Does MOG Ig-positive AQP4-seronegative opticospinal inflammatory disease justify a diagnosis of NMO spectrum disorder?

Scott S. Zamvil, Anthony J. Slavin
First published January 22, 2015, DOI: https://doi.org/10.1212/NXI.0000000000000062
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Article Information

vol. 2 no. 1 e62
DOI: 
https://doi.org/10.1212/NXI.0000000000000062
PubMed: 
25635259
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Online ISSN: 
2332-7812
History: 
  • Received October 24, 2014
  • Accepted in final form December 1, 2014
  • First Published January 22, 2015.
Copyright & Usage: 
© 2015 American Academy of Neurology This is an open access article distributed under the terms of the Creative Commons Attribution-Noncommercial No Derivative 3.0 License, which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially.

Author Disclosures

    1. Scott S. Zamvil, MD, PhD and
    2. Anthony J. Slavin, PhD
  1. Scott S. Zamvil, MD, PhD and
    2. Scientific Advisory Boards:

    1. Dr. Zamvil has received honoraria for serving on Data Safety Monitoring Boards for MS trials conducted by BioMS, Teva Pharmaceuticals, Inc. and Eli Lilly and Co.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) Neurology, Neuroimmunology and Neuroinflammation, Associate Editor, 2011-present (2) Journal the Neurological Sciences, Associate Editor, 2011-present

    Patents:

    1. “Aquaporin-4 peptides and methods for using same” (SF2010-074; USF-461PRV (pending). The application describes the discovery of aquaporin-4 T cell determinants in neuromyelitis optica patients and the use for antigen-specific tolerance.

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. SSZ has received honoraria for speaking engagements for Biogen-Idec, Teva-Neuroscience, and Genzyme.

    Consultancies:

    1. SSZ has served as a consultant to Biogen Idec, Teva Neuroscience, EMD-Serono, Genzyme and Novartis

    Speakers' Bureaus:

    1. Advanced Health Media, 2009-present Biogen Idec, 2009-present

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH RO1 AI073737 NIH RO1 NS 063008

    Research Support, Academic Entities:

    1. NMSS RG 4768A9/1 NMSS RG 5180A11/1

    Research Support, Foundations and Societies:

    1. Guthy Jackson Charitable Foundation, PI Alexander M. and June L. Maisin Foundation, PI

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Anthony J. Slavin, PhD
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. Anthony Slavin is currently an employee of Abbvie Bioresearch Center and was formerly an employee of Boehringer Ingelheim Pharmaceuticals

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Anthony Slavin is currently an employee of Abbvie Bioresearch Center and was formerly an employee of Boehringer INgelheim Pharmaceuticals

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Department of Neurology and Program in Immunology (S.S.Z.), University of California, San Francisco; and Abbvie Bioresearch Center Inc. (A.J.S.), Worcester, MA.
  1. Correspondence to Dr. Zamvil: zamvil{at}ucsf.neuroimmunol.org
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