GABAA receptor and LGI1 antibody encephalitis in a patient with thymoma
Citation Manager Formats
Make Comment
See Comments

Article Information
- Received November 5, 2014
- Accepted in final form December 31, 2014
- First Published February 12, 2015.
Author Disclosures
- Mateus Mistieri Simabukuro, MD*,
- Mar Petit-Pedrol, BS*,
- Luiz H. Castro, MD,
- Ricardo Nitrini, MD, PhD,
- Leandro Lucato, MD,
- Antônio Alberto Zambon, MD,
- Lis Gomes Silva, MD,
- Gabriela Carneiro Rosa Fortes, MD,
- Herval Ribeiro Soares Neto, MD and
- Josep O. Dalmau, MD, PhD
- Mateus Mistieri Simabukuro, MD*,
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
(1) Private neurology practice in Samaritano Hospital
NONE
NONE
This work was supported in part by (1) National Institutes of Health grant RO1NS077851, (2) Fondo de Investigaciones Sanitarias grant PI11/01780(Dr Dalmau).
NONE
This work was supported in part by (1) Fundació la Marató TV3
NONE
NONE
NONE
NONE
NONE
NONE
- Mar Petit-Pedrol, BS*,
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Luiz H. Castro, MD,
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
State of Sao Paulo (Brazil) Research Council - Process 05/56464-9 (Principal Investigator)
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Ricardo Nitrini, MD, PhD,
Advisory board meeting of Janssen-Cilag in 2012 Advisory meeting with Brazilian Nutricia board in 2013
NONE
Funding for travel to Alzheimer Association International Congress. Novartis 2012 and 2013
Editor - Dementia & Neuropsychologia 2007-present Editorial Board member- Alzheimer's Disease and Associated Disordes - 2004-present Editorial Board member - International Journal of Alzheimer's Disease 2011-present
NONE
NONE
NONE
NONE
Speaker in a meeting sponsored by Novartis in 2012 peaker in a meeting sponsored by Danone (Nutricia) in 2013
NONE
I work in private clinic as clinical neurologist
NONE
NONE
NONE
FAPESP (Foundation for the support of research in the S?o Paulo State, Brazil) for epidemiology study on dementia in Brazil Federico Foundation
NONE
NONE
NONE
NONE
NONE
NONE
- Leandro Lucato, MD,
NONE
NONE
NONE
(1) Arquivos de Neuro-Psiquiatria, Associate editor (Neuroimaging), since 2010.
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Antônio Alberto Zambon, MD,
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Lis Gomes Silva, MD,
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Gabriela Carneiro Rosa Fortes, MD,
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Herval Ribeiro Soares Neto, MD and
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Josep O. Dalmau, MD, PhD
NONE
NONE
NONE
Neurology, Neuroimmunology and Neuroinflammation Neurology UpToDate
Patent for Ma2 autoantibody test, patent number: 6,387,639; Issued May 14th, 2002 Patent for NMDA receptor autoantibody test; US 7,972,796 B2 July 5, 2011; European 2057466 Patents filed for GABA(B) receptor autoantibody test, GABA(A) receptor autoantibody test, DPPX autoantibody test, and IgLON5 autoantibody test.
NONE
NONE
Advance Medical
NONE
NONE
NMDAR autoantibody determination in the context of research.
Euroimmun, research support ISCIII
NIH, RO1NS077851 (previously RO1CA107192), PI, 2011-2016 NIH, RO1CA89054, PI, 2008-2013 Fondo de Investigaciones Sanitarias de la Seguridad Social (Spanish Government), 11/01780, PI, 2012-2015
NONE
NONE
NONE
NMDA receptor autoantibody test/Euroimmun GABA(B)R autoantibody test/Euroimmun GABA(A)R autoantibody test/Euroimmun DPPX autoantibody test/Euroimmun Iglon5 autoantibody test/Euroimmun
Patent Ma2 autoantibody test Patent NMDAR autoantibody test Patent application for the use of GABA(B) receptor, GABA (A) receptor, DPPX and IgLON5 autoantiboddy tests
NONE
NONE
NONE
- From the Neurology Division (M.M.S., L.H.C., R.N., A.A.Z., L.G.S., G.C.R.F., H.R.S.N.) and Radiology Institute (L.L.), Hospital das Clínicas, São Paulo University, São Paulo, Brazil; August Pi i Sunyer Biomedical Research Institute (IDIBAPS) (M.P.-P., J.O.D.), Barcelona, Spain; Department of Neurology (J.O.D.), University of Pennsylvania, Philadelphia, PA; and Catalan Institution for Research and Advanced Studies (ICREA) (J.O.D.), Barcelona, Spain.
- Correspondence to Dr. Simabukuro: mateus.simabukuro{at}hc.fm.usp.br
Article usage
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Hastening the Diagnosis of Amyotrophic Lateral Sclerosis
Dr. Brian Callaghan and Dr. Kellen Quigg
► Watch
Topics Discussed
Alert Me
Recommended articles
-
Article
Investigations in GABAA receptor antibody-associated encephalitisMarianna Spatola, Mar Petit-Pedrol, Mateus Mistieri Simabukuro et al.Neurology, February 15, 2017 -
Special Article
NMDA receptor encephalitis and other antibody-mediated disorders of the synapseThe 2016 Cotzias LectureJosep Dalmau et al.Neurology, December 05, 2016 -
Article
Clinical significance of anti-NMDAR concurrent with glial or neuronal surface antibodiesEugenia Martinez-Hernandez, Mar Guasp, Anna García-Serra et al.Neurology, March 11, 2020 -
Article
Improving the antibody-based evaluation of autoimmune encephalitisLindsey McCracken, Junxian Zhang, Maxwell Greene et al.Neurology: Neuroimmunology & Neuroinflammation, October 11, 2017