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June 2015; 2 (3) Clinical/Scientific NotesOpen Access

Encephalomyeloneuropathy with CRMP-5 antibodies in a patient with a primary mediastinal serinoma

Cliff W. Hampton, Dina Galperin, Enrique Alvarez, Matthew S. West
First published March 12, 2015, DOI: https://doi.org/10.1212/NXI.0000000000000082
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  • Figure
    Figure MRI demonstrating cerebellar encephalitis, longitudinally extensive transverse myelitis, and pathology of seminoma

    (A) Parasagittal T1 postcontrast images of the cervical spine demonstrate homogenous enhancement of the spinal cord from the craniocervical junction that extends through the midthoracic spine and also several ill-defined mass-like areas of enhancement in both cerebellar hemispheres involving both cortex and white matter. (B) Parasagittal T2 image demonstrating increased signal in these same areas. (C) Axial T1 postcontrast image demonstrating that the enhancement is primarily dorsal. (D) Axial T2 image with increased signal in the dorsal cord. (E, F) Axial T1-weighted postcontrast images demonstrating multifocal areas of patchy enhancement in the cerebellum. (G) Mediastinal soft tissue mass demonstrates positive immunohistochemistry for placental alkaline phosphatase and (H) CD 117. These are characteristic of seminoma.

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