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August 2015; 2 (4) Clinical/Scientific NotesOpen Access

Posterior cortical and white matter changes on MRI in anti–AMPA receptor antibody encephalitis

Marwa Elamin, Roisin Lonergan, Ronan P. Killeen, Sean O'Riordan, Niall Tubridy, Christopher McGuigan
First published May 21, 2015, DOI: https://doi.org/10.1212/NXI.0000000000000118
Marwa Elamin
From Trinity Biomedical Sciences Institute (M.E.) and St. Vincent's University Hospital (R.L., R.P.K., S.O., N.T., C.M.), Dublin, Ireland.
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Roisin Lonergan
From Trinity Biomedical Sciences Institute (M.E.) and St. Vincent's University Hospital (R.L., R.P.K., S.O., N.T., C.M.), Dublin, Ireland.
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Ronan P. Killeen
From Trinity Biomedical Sciences Institute (M.E.) and St. Vincent's University Hospital (R.L., R.P.K., S.O., N.T., C.M.), Dublin, Ireland.
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Sean O'Riordan
From Trinity Biomedical Sciences Institute (M.E.) and St. Vincent's University Hospital (R.L., R.P.K., S.O., N.T., C.M.), Dublin, Ireland.
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Niall Tubridy
From Trinity Biomedical Sciences Institute (M.E.) and St. Vincent's University Hospital (R.L., R.P.K., S.O., N.T., C.M.), Dublin, Ireland.
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Christopher McGuigan
From Trinity Biomedical Sciences Institute (M.E.) and St. Vincent's University Hospital (R.L., R.P.K., S.O., N.T., C.M.), Dublin, Ireland.
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Citation
Posterior cortical and white matter changes on MRI in anti–AMPA receptor antibody encephalitis
Marwa Elamin, Roisin Lonergan, Ronan P. Killeen, Sean O'Riordan, Niall Tubridy, Christopher McGuigan
Neurol Neuroimmunol Neuroinflamm Aug 2015, 2 (4) e118; DOI: 10.1212/NXI.0000000000000118

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    Figure MRI brain 6 weeks post admission

    (A–C) Symmetrical high signal changes on fluid-attenuated inversion recovery sequences predominantly affecting the cortex, subcortical, and deep white matter in the posterior temporal and parieto-occipital regions. The areas of abnormal signal are wedge-shaped and extend to the ependymal surface of the lateral ventricles. There is gyral swelling and sulcal effacement. The limbic cortex is spared. (D) T1- weighted sequences plus contrast demonstrating lack of significant contrast enhancement. Of note, there was no diffusion restriction.

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