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August 2015; 2 (4) ArticleOpen Access

Myopathy with anti-HMGCR antibodies

Perimysium and myofiber pathology

Ali Alshehri, Rati Choksi, Robert Bucelli, Alan Pestronk
First published June 4, 2015, DOI: https://doi.org/10.1212/NXI.0000000000000124
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Article Information

vol. 2 no. 4 e124
DOI: 
https://doi.org/10.1212/NXI.0000000000000124
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Online ISSN: 
2332-7812
History: 
  • Received February 23, 2015
  • Accepted in final form May 1, 2015
  • First Published June 4, 2015.
Copyright & Usage: 
© 2015 American Academy of Neurology This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially.

Author Disclosures

    1. Ali Alshehri, MD,
    2. Rati Choksi, MS,
    3. Robert Bucelli, MD, PhD and
    4. Alan Pestronk, MD
  1. Ali Alshehri, MD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Rati Choksi, MS,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Robert Bucelli, MD, PhD and
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. 1) Parents of a family member I care for with Parsonage Turner syndrome, a financial gift was provided to me in hopes that it could be used towards Parsonage Turner research

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Alan Pestronk, MD
    5. Scientific Advisory Boards:

    1. Myositis Association, scientific advisory board

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. (1) TS-HDS antibody 7,175,989, issued 2007; (2) GALOP antibody 6,121,004, issued 2000; (3) GM1 ganglioside antibody 6,077,681, issued 2000; (4) Sulfatide antibody 6,020,140, issued 1995

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. Athena, speaker honoraria 2007-2009 The Myositis Association 2014-2015

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Genzyme, (2) Insmed, (3) Knopp, (4) Ultragenyx, (5) ISIS, (6) Sanofi, (7) Cytokinetics, (8) GSK, (9) Biogen, (10) CSL Behring

    Research Support, Government Entities:

    1. NIH

    Research Support, Academic Entities:

    1. Washington University Neuromuscular Research Fund

    Research Support, Foundations and Societies:

    1. (1) CINRG Children's Hospital Washington DC, Investigator 2007–2009; (2) Muscular Dystrophy Association, Investigator 2007-2009

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Department of Neurology (A.A., R.C., R.B., A.P.) and Department of Pathology and Immunology (A.P.), Washington University School of Medicine, Saint Louis, MO.
  1. Correspondence to Dr. Pestronk: pestronka{at}neuro.wustl.edu
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