Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology: Neuroimmunology & Neuroinflammation COVID-19 Article Hub
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
    • UDDA Revision Series
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit New Manuscript
    • Submit Revised Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology: Neuroimmunology & Neuroinflammation COVID-19 Article Hub
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
    • UDDA Revision Series
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit New Manuscript
    • Submit Revised Manuscript
    • Author Center
  • Home
  • Articles
  • Issues
  • COVID-19 Article Hub
  • Infographics & Video Summaries

User menu

  • My Alerts
  • Log in

Search

  • Advanced search
Neurology Neuroimmunology & Neuroinflammation
Home
A peer-reviewed clinical and translational neurology open access journal
  • My Alerts
  • Log in
Site Logo
  • Home
  • Articles
  • Issues
  • COVID-19 Article Hub
  • Infographics & Video Summaries

Share

August 2015; 2 (4) Clinical/Scientific NotesOpen Access

Diagnostic value of MRI in inflammatory myositis

Tim Tien Lai, Tahseen Mozaffar
First published July 9, 2015, DOI: https://doi.org/10.1212/NXI.0000000000000128
Tim Tien Lai
From the Department of Neurology, University of California, Irvine.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tahseen Mozaffar
From the Department of Neurology, University of California, Irvine.
MD, FAAN, FANA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Citation
Diagnostic value of MRI in inflammatory myositis
Tim Tien Lai, Tahseen Mozaffar
Neurol Neuroimmunol Neuroinflamm Aug 2015, 2 (4) e128; DOI: 10.1212/NXI.0000000000000128

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
729

Share

  • Article
  • Figures & Data
  • Info & Disclosures
Loading

A 65-year-old woman presented with a 5-week history of generalized weakness and myalgia. She had a history of seropositive myasthenia gravis post thymectomy for invasive thymoma and was in pharmacologic remission on prednisone and methotrexate. Although limited by significant pain, examination showed diffuse proximal and distal weakness. Serum creatine kinase (CK) was 572 IU/L. Myositis antibody panel was negative. MRI of her left extremities showed patchy muscle edema and inflammation (figures 1 and 2). Given the history of myasthenia gravis and thymoma, diagnosis of granulomatous myositis was made.1 Increased doses of prednisone and methotrexate resulted in resolution of pain and weakness and normalization of CK levels (51 IU/L).

Figure 1
  • Download figure
  • Open in new tab
  • Download powerpoint
Figure 1 Axial short T1 inversion recovery image of left thigh showing multifocal hyperintensities involving the gracilis (A), semitendinosus (B), and vastus lateralis (C) muscles.
Figure 2
  • Download figure
  • Open in new tab
  • Download powerpoint
Figure 2 Focal hyperintense signal in the gastrocnemius muscle on sagittal short T1 inversion recovery image of the left calf.

Footnotes

  • Author contributions: Tim Tien Lai: drafting and revising the manuscript, acquisition of figures. Tahseen Mozaffar: drafting and revising the manuscript, study concept or design, interpretation of data.

  • Study funding: No targeted funding reported.

  • Disclosures: T.T. Lai reports no disclosures. T. Mozaffar serves on medical and scientific advisory boards for the Myositis Association, Genzyme Genetics, Idera Pharmaceuticals, and Ultragenyx; received travel reimbursement for advisory board meetings from Genzyme Corporation, Biomarin, and Amicus; has consulted for Amicus, Biomarin, Genzyme, Sarepta, and Ultragenyx; and received research support from Alnylam, Alexion, Amicus, Biomarin, CSL, Genzyme, ISIS, GSK, Novartis, Ultragenyx, and NIH. Go to Neurology.org/nn for full disclosure forms. The Article Processing Charge was paid by the authors.

  • Received April 21, 2015.
  • Accepted in final form April 28, 2015.
  • © 2015 American Academy of Neurology

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially.

References

  1. 1.↵
    1. Shoenfeld Y,
    2. Cervera R,
    3. Gershwin ME
    1. Prieto S,
    2. Grau JM
    . Granulomatous myositis. In: Shoenfeld Y, Cervera R, Gershwin ME, editors. Diagnostic Criteria in Autoimmune Diseases. Totowa, NJ: Humana Press; 2008:175–177.

Letters: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Footnotes
    • References
  • Figures & Data
  • Info & Disclosures
Advertisement

Association of Mediterranean-DASH Intervention for Neurodegenerative Delay and Mediterranean Diets With Alzheimer Disease Pathology

Dr. Babak Hooshmand and Dr. David Smith

► Watch

Related Articles

  • No related articles found.

Topics Discussed

  • MRI
  • Myasthenia
  • Muscle disease

Alert Me

  • Alert me when eletters are published

Recommended articles

  • Clinical/Scientific Notes
    Diagnostic challenge and therapeutic dilemma in necrotizing myopathy
    Kristl G. Claeys, Olga Gorodinskaya, Susanne Handt et al.
    Neurology, August 06, 2013
  • Article
    Inflammatory myopathy with myasthenia gravis
    Thymoma association and polymyositis pathology
    Naohiro Uchio, Kenichiro Taira, Chiseko Ikenaga et al.
    Neurology: Neuroimmunology & Neuroinflammation, December 24, 2018
  • Articles
    Distinct muscle imaging patterns in myofibrillar myopathies
    D. Fischer, R. A. Kley, K. Strach et al.
    Neurology, September 02, 2008
  • Article
    Isolated inclusion body myopathy caused by a multisystem proteinopathy–linked hnRNPA1 mutation
    Rumiko Izumi, Hitoshi Warita, Tetsuya Niihori et al.
    Neurology Genetics, September 24, 2015
Neurology - Neuroimmunology Neuroinflammation: 10 (6)

Articles

  • Articles
  • Issues
  • Popular Articles

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Education
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology: Neuroimmunology & Neuroinflammation
Online ISSN: 2332-7812

© 2023 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise