Share

August 2015; 2 (4) Views & ReviewsOpen Access

Acute optic neuritis

Unmet clinical needs and model for new therapies

Steven L. Galetta, Pablo Villoslada, Netta Levin, Kenneth Shindler, Hiroshi Ishikawa, Edward Parr, Diego Cadavid, Laura J. Balcer
First published July 23, 2015, DOI: https://doi.org/10.1212/NXI.0000000000000135
Full PDF
Citation
Permissions

Make Comment

See Comments

Downloads
2665

Share

Article Information

vol. 2 no. 4 e135
DOI: 
https://doi.org/10.1212/NXI.0000000000000135
PubMed: 
26236761
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Online ISSN: 
2332-7812
History: 
  • Received February 12, 2015
  • Accepted in final form May 13, 2015
  • First Published July 23, 2015.
Copyright & Usage: 
© 2015 American Academy of Neurology This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially.

Author Disclosures

    1. Steven L. Galetta, MD,
    2. Pablo Villoslada, MD,
    3. Netta Levin, MD, PhD,
    4. Kenneth Shindler, MD, PhD,
    5. Hiroshi Ishikawa, MD,
    6. Edward Parr, PhD,
    7. Diego Cadavid, MD and
    8. Laura J. Balcer, MD, MSCE
  1. Steven L. Galetta, MD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Biogen and Genzyme

    Editorial Boards:

    1. (1) Neurology, Editorial Board; (2) Journal of Neuro-ophthalmology, Editorial Board

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Genzyme Biogen

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Pablo Villoslada, MD,
    3. Scientific Advisory Boards:

    1. Roche, Novartis, Neurotec Farma, Bionure Farma; Consultant: Novartis, Roche, TFS, Heidelberg Engineering, MedImmune, Digna Biotec, Neurotec Pharma

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Novartis

    Editorial Boards:

    1. PloSONE Academic editor since 2011, Neurology & Therapy, Curr There Op Neurol

    Patents:

    1. 1. Methyltioadenosine for the treatment of MS 2. Agonistic neurotrophic compounds for the treatment of brain diseases 3. Gene signature pattern as a biomarker for MS

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. unrestricted grants from, Novartis Roche

    Research Support, Government Entities:

    1. Instituto de Salud Carlos III, European Commission,

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Fundacion Maraton TV3

    Stock/Stock Options/Board of Directors Compensation:

    1. Bionure Pharma

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Netta Levin, MD, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Kenneth Shindler, MD, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. 1) Medical College of Wisconsin, Speaker Honorarium 2) Temple University, Speaker Honorarium

    Editorial Boards:

    1. 1) Frontiers in Neuro-Ophthalmology, Associate Editor, 2011 - present

    Patents:

    1. NONE

    Publishing Royalties:

    1. 1) Tolosa Hunt Syndrome, UpToDate, Authorship Honorarium 2004 - 2015 2) Neuro-Ophthalmology, Oakstone Publishing, Authorship Honararium 2014

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Consultation in the form of medical record review and independent medical examinations of medical-legal cases for various law firms and insurance companies. Several cases each year.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. 1) Stemnion, Inc.

    Research Support, Government Entities:

    1. 1) NIH, EY019014, PI 2010-present

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1) RPB 2) ITMAT 3) F.M. Kirby Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. Consultation in the form of medical record review and independent medical examinations of medical-legal cases for various law firms and insurance companies. Several cases each year.

  5. Hiroshi Ishikawa, MD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH R01-EY013178, P30 EY008098, Co-investigator

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Edward Parr, PhD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. (1) Excel Scientific Solutions*, medical writer, 10 years (*contracted by Biogen Idec to provide writing support for this manuscript)

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Diego Cadavid, MD and
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. I'm a full time paid employee of Biogen, a biopharmaceutical company involved in research and development in the field related to the published article.

    Editorial Boards:

    1. NONE

    Patents:

    1. I'm listed as an inventor on pending patent applications related to the use of drugs that block LINGO-1 to treat demyelination in multiple sclerosis.

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. I'm a full time paid employee of Biogen and own stock and restricted stock units in Biogen.

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. I have been a full time paid employee of Biogen for over 7 years.

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. I own restricted stock units and stock as compensation for my full time employment at Biogen.

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. I own restricted stock units and stock as compensation for my full time employment at Biogen.

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Laura J. Balcer, MD, MSCE
    9. Scientific Advisory Boards:

    1. Biogen, Genzyme

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. (1) Biogen, consulting; (2) Genzyme, consulting;

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Biogen Idec, Novartis, Vaccinex, Questcor, Acorda

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Departments of Neurology (S.L.G., L.J.B.), Ophthalmology (S.L.G., L.J.B.), and Population Health (L.J.B.), New York University School of Medicine, New York, NY; Center of Neuroimmunology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) and Hospital Clinic of Barcelona (P.V.), Barcelona, Spain; Department of Neurology (P.V.), University of California, San Francisco; Department of Neurology (N.L.), The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew-University Medical Center, Jerusalem, Israel; Scheie Eye Institute and FM Kirby Center for Molecular Ophthalmology (K.S.), University of Pennsylvania, Philadelphia; UPMC Eye Center (H.I.), Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, PA; Department of Bioengineering (H.I.), Swanson School of Engineering, University of Pittsburgh, PA; Excel Scientific Solutions (E.P.), Southport, CT; and Biogen (D.C.), Cambridge, MA.
  1. Correspondence to Dr. Balcer: laura.balcer{at}nyumc.org
View Full Text

Article usage

Article usage: July 2015 to May 2023

AbstractFullPdfSource
Jul 20151255924Highwire
Aug 201544952148Highwire
Aug 2015016890pmc
Sep 2015781225Highwire
Sep 2015011962pmc
Oct 2015491116Highwire
Oct 201507936pmc
Nov 201530919Highwire
Nov 201507743pmc
Dec 2015541012Highwire
Dec 201507938pmc
Jan 2016351218Highwire
Jan 201605946pmc
Feb 20165198Highwire
Feb 201605129pmc
Mar 201652813Highwire
Mar 201607340pmc
Apr 2016361215Highwire
Apr 201605732pmc
May 201639108Highwire
May 201604928pmc
Jun 2016361511Highwire
Jun 201603434pmc
Jul 20163479Highwire
Jul 201602210pmc
Aug 2016271012Highwire
Aug 201603917pmc
Sep 20161924Highwire
Sep 201604120pmc
Oct 2016352410Highwire
Oct 201605818pmc
Nov 201628179Highwire
Nov 201606815pmc
Dec 2016151910Highwire
Dec 201604913pmc
Jan 201730711Highwire
Jan 201704210pmc
Feb 20171686Highwire
Feb 20170319pmc
Mar 2017461821Highwire
Mar 201704918pmc
Apr 201727913Highwire
Apr 2017163940pmc
May 2017261010Highwire
May 2017153131pmc
Jun 20171883Highwire
Jun 201752325pmc
Jul 201713103Highwire
Jul 201783336pmc
Aug 201719145Highwire
Aug 2017143543pmc
Sep 20171285Highwire
Sep 201764948pmc
Oct 2017161812Highwire
Oct 2017143741pmc
Nov 20171386Highwire
Nov 201773034pmc
Dec 20171443Highwire
Jan 201827910Highwire
Feb 20180307Highwire
Mar 20181494Highwire
Apr 2018211510Highwire
Apr 2018103542pmc
May 2018018911Highwire
Jun 201841599Highwire
Jun 2018133439pmc
Jul 2018212819Highwire
Aug 20181637Highwire
Aug 201853842pmc
Sep 201824657Highwire
Oct 2018412213Highwire
Nov 201841998Highwire
Dec 201814748Highwire
Jan 2019451910Highwire
Feb 2019842817Highwire
Mar 2019815025Highwire
Apr 201954111Highwire
May 201995622Highwire
Jun 201988118Highwire
Jul 2019510519Highwire
Aug 2019452820Highwire
Sep 2019510916Highwire
Oct 2019128520Highwire
Nov 201934913Highwire
Dec 201945214Highwire
Jan 202024914Highwire
Feb 202047520Highwire
Mar 202027421Highwire
Apr 202027618Highwire
May 202056111Highwire
Jun 2020105419Highwire
Jul 202014011Highwire
Aug 202016312Highwire
Sep 202077731Highwire
Oct 2020313823Highwire
Nov 202058626Highwire
Dec 202077917Highwire
Jan 202149416Highwire
Feb 202138316Highwire
Mar 202159124Highwire
Apr 202137216Highwire
May 2021313710Highwire
Jun 2021420117Highwire
Jul 2021910029Highwire
Aug 202139710Highwire
Sep 202119419Highwire
Oct 202159347Highwire
Nov 202139630Highwire
Dec 2021111723Highwire
Jan 202249819Highwire
Feb 2022713827Highwire
Mar 202258620Highwire
Apr 2022311317Highwire
May 202257623Highwire
Jun 2022312325Highwire
Jul 2022514020Highwire
Aug 2022818015Highwire
Sep 2022515522Highwire
Oct 2022715725Highwire
Nov 2022817638Highwire
Dec 2022810215Highwire
Jan 2023413624Highwire
Feb 2023610116Highwire
Mar 2023112620Highwire
Apr 2023411526Highwire
May 2023510017Highwire

Letters: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
Advertisement

Related Articles

  • No related articles found.

Topics Discussed

Alert Me

Recommended articles