Article Figures & Data
Figures
- Figure 1 Increased VZV/IE63-specific cellular immune response after 6 months of FTY treatment
Interferon-γ–mediated cellular immune responses against pool of peptides encompassing the whole VZV/IE63 protein (A), VZV viral lysate (B), pool of selected peptides of FLU (C), FLU viral lysate (D), and pool of peptides encompassing the whole JCV VP-1 protein (E) were tested using enzyme-linked immunospot assay. Data were obtained before treatment initiation (T0), and after 6 (T6), 12 (T12), and 24 months (T24) of treatment. Data of FTY-treated patients with multiple sclerosis appear in black in the graphs, NTZ-treated patients in red, and patients under other DMTs in blue. Responses reached by the 2 patients who underwent an HZ during FTY treatment are represented as dots on the graphs. Box and whisker plots show median, 25th and 75th percentiles, and range. The mean is represented as a dot in the box. The effect of the treatment duration for each treated group was assessed in a Kruskal–Wallis test. If significant, T0 was then compared to subsequent time points using pairwise unparametric Wilcoxon tests corrected for Bonferroni multiple comparisons. The asterisks represent differences for the effect of time for a given treatment. In all of these experiments, only data of FTY-treated patients at T6 and for IE63 reached significance; **P < 0.01. FLU = influenza virus; FLU pool = FLU pool of CD8+ restricted peptides; FTY = fingolimod; HZ = herpes zoster; JCV = JC virus; JCV pool = JCV VP-1 protein; NTZ = natalizumab; others = other disease-modifying treatments (DMTs); SFC = spot-forming cell; VZV = varicella-zoster virus; VZV pool = VZV IE63 protein.
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Data Supplement
Files in this Data Supplement:
- Figure e-1 - PowerPoint Presentation
- Figure e-2 - PowerPoint Presentation
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