Clinical utility of testing AQP4-IgG in CSF
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Article Information
- Received November 25, 2015
- Accepted in final form March 15, 2016
- First Published April 20, 2016.
Author Disclosures
- Masoud Majed, MD*,
- James P. Fryer, MS*,
- Andrew McKeon, MD,
- Vanda A. Lennon, MD, PhD and
- Sean J. Pittock, MD
- Masoud Majed, MD*,
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- James P. Fryer, MS*,
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- Andrew McKeon, MD,
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Medimmune, Inc
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- Vanda A. Lennon, MD, PhD and
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Vanda Lennon receives royalties from RSR/Kronus for sale of aquaporin-4 autoantibody testing kits and for commercial aquaporin-4 autoantibody testing performed outside Mayo Clinic.
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NIH R01-NS065829,?CNS Demyelinating Autoimmunity Targeting Water Channel Complexes?. Principal Investigator: S.J. Pittock Co-Investigator: V.A. Lennon Years: 2010-2015
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1) RSR/Kronus for sale of aquaporin-4 autoantibody testing kits. 2) Non-Mayo sites performing “home brew” diagnostic testing for aquaporin-4 autoantibody.
Dr. Lennon has a potential financial interest in the technologies listed below: “Aquaporin-4 as an aid for cancer diagnosis”.
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- Sean J. Pittock, MD
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Dr. Pittock and Mayo Clinic have a financial interest in patents (#12/678,350 filed 2010 and #12/573,942 filed 2008) that relate to functional AQP4/NMO-IgG assays and NMO-IgG as a cancer marker;
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Dr. Pittock has provided consultation to Alexion Pharmaceuticals, Medimmune and Chugai Pharma USA but has received no personal fees or personal compensation for these consulting activities. All compensation for consulting activities is paid directly to Mayo Clinic.
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Dr. Pittock has received a research grant from Alexion pharmaceuticals for his investigator-initiated study entitled
RO1 NS065829-01
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Guthy Jackson Charitable Foundation grant for NMO research
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- From the Departments of Laboratory Medicine and Pathology (M.M., J.P.F., A.M., V.A.L., S.J.P.), Neurology (A.M., V.A.L., S.J.P.), and Immunology (V.A.L.), Mayo Clinic, Rochester, MN.
- Correspondence to Dr. Pittock: pittock.sean{at}mayo.edu
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