Article Figures & Data
Figures
- Figure 1. Principal component analysis (PCA) of patients with amyotrophic lateral sclerosis (ALS) vs controls
PCA analysis shows a good separation between ALS and controls of the expression levels of the 11 cytokines under investigation, more significant when sex-specific groups are considered. (A) ALS (green squares) and controls (yellow squares), (B) male only ALS (green squares) and controls (yellow squares), and (C) female only ALS (green squares) and controls (yellow squares).
- Figure 2. Odds ratios (ORs) from the multivariate logistic regression analysis and hazard ratios (HRs) from the Cox regression analysis
(A) OR (filled circle) and relative 95% confidence interval (CI) (whiskers) of plasma markers in amyotrophic lateral sclerosis (ALS) and controls from mutually adjusted multivariate logistic regression models; dashed line represents null hypothesis (no difference between ALS and controls). (B) HR (filled circles) and relative 95% CI (whiskers) of plasma markers estimating risk of death among patients with ALS from mutually adjusted multivariate Cox regression analysis. The dashed line represents null hypothesis (no association with survival). p < 0.5, 0.5 < p < 0.1, and p > 0.1 are shown in blue, mulberry, and black, respectively. CRP = C-reactive protein; CVD = cardiovascular disease; IFN = interferon; IL = interleukin; TNF = tumor necrosis factor.
- Figure 3. Longitudinal expression levels of interleukin (IL)–6 for patients with amyotrophic lateral sclerosis (ALS)
The scatterplots show IL-6 plasma levels (black dots) obtained at each follow-up time point from the 59 patients with ALS included in the longitudinal cohort. Median and quartile ranges at each visit are presented with red bars. Patients were subgrouped according to (A.a, A.b) progression rate calculated at baseline (with a cutoff value of 0.5); (B.a, B.b) sex; (C.a, C.b) site of disease onset; (D.a, D.b) ALS Functional Rating Scale–Revised (ALSFRS-R) score at V1 (cutoff value of 40); and (E.a, E.b) whether they were on riluzole or not. *p Value for Kruskal-Wallis test examining difference between all visits; **p value adjusted for multiple comparison between V1 and V6; ***p value adjusted for multiple comparison between V2 (D only) and V6.
Tables
Data Supplement
Files in this Data Supplement:
- Figure e-1 - PDF
- Table e-1 - PDF
- Table e-2 - PDF
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