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August 2016; 3 (4) Clinical/Scientific NotesOpen Access

Aquaporin-4 IgG autoimmune syndrome and immunoreactivity associated with thyroid cancer

Kerstin Soelberg, Stine R. Larsen, Marlene T. Moerch, Mads Thomassen, Klaus Brusgaard, Friedemannn Paul, Terry J. Smith, Christian Godballe, Jakob Grauslund, Soeren T. Lillevang, Nasrin Asgari
First published June 16, 2016, DOI: https://doi.org/10.1212/NXI.0000000000000252
Kerstin Soelberg
From Vejle Hospital (K.S., N.A.); Institute of Molecular Medicine (K.S., M.T.M., N.A.), University of Southern Denmark; Odense University Hospital (S.R.L., M.T., K.B., T.J.S., C.G., J.G., S.T.L.), Denmark; Clinical and Experimental Multiple Sclerosis Research Center and NeuroCure Clinical Research Center (F.P.), Charité-Universitätsmedizin Berlin; Experimental and Clinical Research Center (F.P.), Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Germany; and University of Michigan Medical School (T.J.S.), Ann Arbor.
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Stine R. Larsen
From Vejle Hospital (K.S., N.A.); Institute of Molecular Medicine (K.S., M.T.M., N.A.), University of Southern Denmark; Odense University Hospital (S.R.L., M.T., K.B., T.J.S., C.G., J.G., S.T.L.), Denmark; Clinical and Experimental Multiple Sclerosis Research Center and NeuroCure Clinical Research Center (F.P.), Charité-Universitätsmedizin Berlin; Experimental and Clinical Research Center (F.P.), Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Germany; and University of Michigan Medical School (T.J.S.), Ann Arbor.
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Marlene T. Moerch
From Vejle Hospital (K.S., N.A.); Institute of Molecular Medicine (K.S., M.T.M., N.A.), University of Southern Denmark; Odense University Hospital (S.R.L., M.T., K.B., T.J.S., C.G., J.G., S.T.L.), Denmark; Clinical and Experimental Multiple Sclerosis Research Center and NeuroCure Clinical Research Center (F.P.), Charité-Universitätsmedizin Berlin; Experimental and Clinical Research Center (F.P.), Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Germany; and University of Michigan Medical School (T.J.S.), Ann Arbor.
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Mads Thomassen
From Vejle Hospital (K.S., N.A.); Institute of Molecular Medicine (K.S., M.T.M., N.A.), University of Southern Denmark; Odense University Hospital (S.R.L., M.T., K.B., T.J.S., C.G., J.G., S.T.L.), Denmark; Clinical and Experimental Multiple Sclerosis Research Center and NeuroCure Clinical Research Center (F.P.), Charité-Universitätsmedizin Berlin; Experimental and Clinical Research Center (F.P.), Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Germany; and University of Michigan Medical School (T.J.S.), Ann Arbor.
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Klaus Brusgaard
From Vejle Hospital (K.S., N.A.); Institute of Molecular Medicine (K.S., M.T.M., N.A.), University of Southern Denmark; Odense University Hospital (S.R.L., M.T., K.B., T.J.S., C.G., J.G., S.T.L.), Denmark; Clinical and Experimental Multiple Sclerosis Research Center and NeuroCure Clinical Research Center (F.P.), Charité-Universitätsmedizin Berlin; Experimental and Clinical Research Center (F.P.), Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Germany; and University of Michigan Medical School (T.J.S.), Ann Arbor.
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Friedemannn Paul
From Vejle Hospital (K.S., N.A.); Institute of Molecular Medicine (K.S., M.T.M., N.A.), University of Southern Denmark; Odense University Hospital (S.R.L., M.T., K.B., T.J.S., C.G., J.G., S.T.L.), Denmark; Clinical and Experimental Multiple Sclerosis Research Center and NeuroCure Clinical Research Center (F.P.), Charité-Universitätsmedizin Berlin; Experimental and Clinical Research Center (F.P.), Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Germany; and University of Michigan Medical School (T.J.S.), Ann Arbor.
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Terry J. Smith
From Vejle Hospital (K.S., N.A.); Institute of Molecular Medicine (K.S., M.T.M., N.A.), University of Southern Denmark; Odense University Hospital (S.R.L., M.T., K.B., T.J.S., C.G., J.G., S.T.L.), Denmark; Clinical and Experimental Multiple Sclerosis Research Center and NeuroCure Clinical Research Center (F.P.), Charité-Universitätsmedizin Berlin; Experimental and Clinical Research Center (F.P.), Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Germany; and University of Michigan Medical School (T.J.S.), Ann Arbor.
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Christian Godballe
From Vejle Hospital (K.S., N.A.); Institute of Molecular Medicine (K.S., M.T.M., N.A.), University of Southern Denmark; Odense University Hospital (S.R.L., M.T., K.B., T.J.S., C.G., J.G., S.T.L.), Denmark; Clinical and Experimental Multiple Sclerosis Research Center and NeuroCure Clinical Research Center (F.P.), Charité-Universitätsmedizin Berlin; Experimental and Clinical Research Center (F.P.), Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Germany; and University of Michigan Medical School (T.J.S.), Ann Arbor.
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Jakob Grauslund
From Vejle Hospital (K.S., N.A.); Institute of Molecular Medicine (K.S., M.T.M., N.A.), University of Southern Denmark; Odense University Hospital (S.R.L., M.T., K.B., T.J.S., C.G., J.G., S.T.L.), Denmark; Clinical and Experimental Multiple Sclerosis Research Center and NeuroCure Clinical Research Center (F.P.), Charité-Universitätsmedizin Berlin; Experimental and Clinical Research Center (F.P.), Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Germany; and University of Michigan Medical School (T.J.S.), Ann Arbor.
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Soeren T. Lillevang
From Vejle Hospital (K.S., N.A.); Institute of Molecular Medicine (K.S., M.T.M., N.A.), University of Southern Denmark; Odense University Hospital (S.R.L., M.T., K.B., T.J.S., C.G., J.G., S.T.L.), Denmark; Clinical and Experimental Multiple Sclerosis Research Center and NeuroCure Clinical Research Center (F.P.), Charité-Universitätsmedizin Berlin; Experimental and Clinical Research Center (F.P.), Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Germany; and University of Michigan Medical School (T.J.S.), Ann Arbor.
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Nasrin Asgari
From Vejle Hospital (K.S., N.A.); Institute of Molecular Medicine (K.S., M.T.M., N.A.), University of Southern Denmark; Odense University Hospital (S.R.L., M.T., K.B., T.J.S., C.G., J.G., S.T.L.), Denmark; Clinical and Experimental Multiple Sclerosis Research Center and NeuroCure Clinical Research Center (F.P.), Charité-Universitätsmedizin Berlin; Experimental and Clinical Research Center (F.P.), Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Germany; and University of Michigan Medical School (T.J.S.), Ann Arbor.
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Full PDF
Citation
Aquaporin-4 IgG autoimmune syndrome and immunoreactivity associated with thyroid cancer
Kerstin Soelberg, Stine R. Larsen, Marlene T. Moerch, Mads Thomassen, Klaus Brusgaard, Friedemannn Paul, Terry J. Smith, Christian Godballe, Jakob Grauslund, Soeren T. Lillevang, Nasrin Asgari
Neurol Neuroimmunol Neuroinflamm Aug 2016, 3 (4) e252; DOI: 10.1212/NXI.0000000000000252

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    Figure. Paraneoplastic neuromyelitis optica spectrum disorder associated with anti-aquaporin-4 (AQP4) immunoreactivity in an oncocytic thyroid carcinoma

    Micrographs show immunohistochemistry performed on formalin-fixed paraffin-embedded sections of the follicular carcinoma, thin-sectioned and stained for AQP4 and toluidine blue (A, C, D). (A) A sharp border between the neoplastic thyroid tissue (left) and normal thyroid tissue parenchyma (right); (B) (insert) shows negative control. (C) Multifocal high-level expression of AQP4 in the neoplastic thyroid cells, which is distinctly different from the normal thyroid tissue. (D) Magnified view of B shows AQP4 immunoreactivity predominately in the cell membrane (arrowheads). Scale bars = 200 μm (A, B), 100 μm (C), 20 μm (D).

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