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January 2017; 4 (1) ArticleOpen Access

Isolated dysphagia as initial sign of anti-IgLON5 syndrome

Jens Burchard Schröder, Nico Melzer, Tobias Ruck, Anna Heidbreder, Ilka Kleffner, Ralf Dittrich, Paul Muhle, Tobias Warnecke, Rainer Dziewas
First published November 22, 2016, DOI: https://doi.org/10.1212/NXI.0000000000000302
Jens Burchard Schröder
From the Division of Sleep Medicine and Neuromuscular Disorders (A.H.), Department of Neurology (J.B.S., N.M., T.R., A.H., I.K., R.D., P.M., T.W., R.D.), University of Münster, Germany.
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Nico Melzer
From the Division of Sleep Medicine and Neuromuscular Disorders (A.H.), Department of Neurology (J.B.S., N.M., T.R., A.H., I.K., R.D., P.M., T.W., R.D.), University of Münster, Germany.
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Tobias Ruck
From the Division of Sleep Medicine and Neuromuscular Disorders (A.H.), Department of Neurology (J.B.S., N.M., T.R., A.H., I.K., R.D., P.M., T.W., R.D.), University of Münster, Germany.
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Anna Heidbreder
From the Division of Sleep Medicine and Neuromuscular Disorders (A.H.), Department of Neurology (J.B.S., N.M., T.R., A.H., I.K., R.D., P.M., T.W., R.D.), University of Münster, Germany.
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Ilka Kleffner
From the Division of Sleep Medicine and Neuromuscular Disorders (A.H.), Department of Neurology (J.B.S., N.M., T.R., A.H., I.K., R.D., P.M., T.W., R.D.), University of Münster, Germany.
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Ralf Dittrich
From the Division of Sleep Medicine and Neuromuscular Disorders (A.H.), Department of Neurology (J.B.S., N.M., T.R., A.H., I.K., R.D., P.M., T.W., R.D.), University of Münster, Germany.
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Paul Muhle
From the Division of Sleep Medicine and Neuromuscular Disorders (A.H.), Department of Neurology (J.B.S., N.M., T.R., A.H., I.K., R.D., P.M., T.W., R.D.), University of Münster, Germany.
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Tobias Warnecke
From the Division of Sleep Medicine and Neuromuscular Disorders (A.H.), Department of Neurology (J.B.S., N.M., T.R., A.H., I.K., R.D., P.M., T.W., R.D.), University of Münster, Germany.
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Rainer Dziewas
From the Division of Sleep Medicine and Neuromuscular Disorders (A.H.), Department of Neurology (J.B.S., N.M., T.R., A.H., I.K., R.D., P.M., T.W., R.D.), University of Münster, Germany.
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Full PDF
Citation
Isolated dysphagia as initial sign of anti-IgLON5 syndrome
Jens Burchard Schröder, Nico Melzer, Tobias Ruck, Anna Heidbreder, Ilka Kleffner, Ralf Dittrich, Paul Muhle, Tobias Warnecke, Rainer Dziewas
Neurol Neuroimmunol Neuroinflamm Jan 2017, 4 (1) e302; DOI: 10.1212/NXI.0000000000000302

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    Figure Investigations

    (A) T1 gadolinium-enhanced axial MRI shows no evidence of underlying brainstem or cranial nerve pathology. (B) No intrathecal immunoglobulin synthesis was observed in CSF analysis using the Reiber scheme. (C) Fiber optic endoscopic evaluation of swallowing reveals postdeglutitive residue in the valleculae epiglotticae (3), on top of the epiglottis (2), and in the piriform sinuses (1).

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