IgG-specific cell-based assay detects potentially pathogenic MuSK-Abs in seronegative MG
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Article Information
- Received November 19, 2016
- Accepted in final form April 6, 2017
- First Published June 5, 2017.
Author Disclosures
- Saif Huda, MD,
- Patrick Waters, PhD,
- Mark Woodhall, PhD,
- Maria Isabel Leite, DPhil,
- Leslie Jacobson, DPhil,
- Anna De Rosa, MD,
- Michelangelo Maestri, MD,
- Roberta Ricciardi, MD,
- Jeannine M. Heckmann, PhD,
- Angelina Maniaol, PhD,
- Amelia Evoli, MD,
- Judy Cossins, DPhil,
- David Hilton-Jones, MD and
- Angela Vincent, FRCPath
- Saif Huda, MD,
(1) Medefield
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- Patrick Waters, PhD,
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Honoraria from Biogen Idec Japan, Euroimmun AG and Mereo Biopharma.
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Assays for the detection of antibodies to lgi1, Caspr2, Tag-1 and GABAAR.
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Our laboratory runs routine diagnostic assays, one of which is for GABAAR antibodies.
Euroimmun AG
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Patents for CASPR2, LGI1, TAG-1 and GABAAR.
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- Mark Woodhall, PhD,
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- Maria Isabel Leite, DPhil,
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Dr. Maria Isabel Leite is supported by NHS National Specialised Commissioning Group for Neuromyelitis Optica, UK, and by NIHR Oxford Biomedical Research Centre, and has received travel grant and speaking honoraria from Biogen Idec and travel grant from Novartis.
Neuromuscular Disorders, editorial board member, from January 2014
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- Leslie Jacobson, DPhil,
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- Anna De Rosa, MD,
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- Michelangelo Maestri, MD,
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- Roberta Ricciardi, MD,
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- Jeannine M. Heckmann, PhD,
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Scientific Reports, associate editor, 2016-2017
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South African Medical Research Council (MRC) grant, Principal Investigator, 2014-2017 AFM Telethon, Principal Investigator, 2016-2017
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AFM-Telethon grant no 20049
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- Angelina Maniaol, PhD,
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The Norwegian Association of Muscle diseases (Fondet for Foreningen for Muskelsyke)
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- Amelia Evoli, MD,
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Scientific award jury member for Grifols
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- Judy Cossins, DPhil,
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- David Hilton-Jones, MD and
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(1) Editorial Advisoy Board, Neuromuscular Disorders since 2004. No financial compensation; (2) Editorial Board, Practical Neurology, since 2000. No financial compensation.
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Disorders of Voluntary Muscle - several editions in last 20 years from Churchill Livingstone and Cambridge University Press Oxford Textbook of Neurology (Neuromuscular Disorders), OUP, 2015
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- Angela Vincent, FRCPath
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Bial Commercial, Portugal travel and speaker honorarium
Advisory Editorial Board Neurology 2014 - Associate Editor for Brain ended 2013
Hold patent with Oxford University for MuSK antibodies and for LGI1/CASPR2 antibodies
Royalties for Clinical Neuroimmunology (Blackwell Publishing, 2005) and Inflammatory and Autoimmune Disorders of the Nervous System in Children (Mac Keith Press 2010) and for Pittock and Vincent Handbook of Neurology 2017 (Elsevier).
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Consultancy with Athena Diagnostics for assessing their antibody assays ?5K pa. Ended 2014.
Scientific conference expenses only
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Royalties from Athena Diagnostics (MuSK assays). Royalties received from Euroimmun AG (LGI1 and CASPR2 assays)
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NIHR general support for antibody work
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- From the Nuffield Department of Clinical Neurosciences (S.H., P.W., M.W., M.I.L., L.J., J.C., D.H.-J., A.V.), University of Oxford, UK; Department of Clinical and Experimental Medicine (A.D.R., M.M., R.R.), Neurology Unit, Pisa, Italy; Division of Neurology (J.M.H.), University of Cape Town, South Africa; Oslo University Hospital (A.M.), Norway; and Department of Neuroscience (A.E.), Catholic University, Rome, Italy.
- Correspondence to Prof. Vincent: angela.vincent{at}ndcn.ox.ac.uk
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