Lipoic acid in secondary progressive MS
A randomized controlled pilot trial
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Article Information
- Received March 7, 2017
- Accepted in final form May 15, 2017
- First Published June 28, 2017.
Author Disclosures
- Rebecca Spain, MD, MSPH,
- Katherine Powers, BA, CCRP,
- Charles Murchison, MS,
- Elizabeth Heriza, MD,
- Kimberly Winges, MD,
- Vijayshree Yadav, MD, MSCR,
- Michelle Cameron, MD, PT,
- Ed Kim, MD,
- Fay Horak, PhD, PT,
- Jack Simon, MD, PhD and
- Dennis Bourdette, MD
- Rebecca Spain, MD, MSPH,
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Department of Veterans Affairs, B7493-W, 2010-2015 Oregon Clinical and Translational Research Institute, (UL1TR000128), 2010-2015
1. VA Portland Health Care System 2. Oregon Health & Science University
National MS Society Conrad Hilton FOundation Medical Research Foundation of Oregon Race to Erase MS
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- Katherine Powers, BA, CCRP,
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- Charles Murchison, MS,
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- Elizabeth Heriza, MD,
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- Kimberly Winges, MD,
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- Vijayshree Yadav, MD, MSCR,
(1) Genentech
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Consultant - Bayer's Advisory meeting Consultant - Biogen National Advisory Committee Consultant - Teva MS Medical Advisory board meeting
Novartis Inc. Biogen Idec
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(1)Biogen Idec
(1) Department of Veterans Affairs, 3427, Primary Investigator, 4
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(1) McDougall Foundation, Research grant funding (2) National MS Society (3) Race to Erase MS Foundation (5) National Institute of Health
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- Michelle Cameron, MD, PT,
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I have received compensation for travel from the Consortium of Multiple Sclerosis Centers and the VA Portland Research Foundation.
I am an editorial advisory board member with no compensation for the Journal of Hand Therapy and an editor for the section on demyelinating disorders with no compensation for Nature Reviews Neuroscience.
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I receive publishing royalties for the following books: (1) Physical Agents in Rehabilitation: From Research to Practice 4th edition; Elsevier, 2012 (2) Physical Rehabilitation; Elsevier, 2009 (3) Physical Rehabilitation for the Physical Therapist Assistant; Elsevier, 2010
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I provide consultation to (1) Re-walk corporation (2) Adamas corporation
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I have received research support from: (1) the Department of Veterans Affairs, Rehabilitation Research and Development Service
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I have received research support from (1) National MS Society (2) Paralyzed Veterans of America Foundation.
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- Ed Kim, MD,
I served on an advisory boards once for both Genzyme and Teva Pharmaceutical within the past 2 years.
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1) National MS Society; Multicenter Randomized Clinical Trial of high dose vs low dose vitamin D.
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- Fay Horak, PhD, PT,
MS Society, Grant Reviewer, 2010-2016 APDM,Inc, Co-owner and employee NIH NCMRR Advisory Council, 2015-2017
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Received travel expenses and honoraria for lectures and educational activities not funded by industry
(1) Gait and Posture, Senior Assoc Editor 1993-2006, Board 2008-2017 (2)Cerebellum, Assoc Editor, 2001-2015 (3) J of Biomechanics, Editorial Board, 2008-present (4) Encyclopedia for Neuroscience, Associate Editor, 2005-7 (5) Frontiers in Neurology, Editorial Board, 2015-17 (6) Frontiers in Neuro-otoloyg, Editorial Board, 2010-2017
1) Devise for conditioning balance and motor coordination European Patent No 04736776.8 2) Instrumented Mobility System to objectively measure Balance and Gait, US patent pending
Chapter 39, Posture Control in Kandel and Schwartz, 4th Editor, Principles of Neuroscience, McGraw-Hill, 2000-2017
Received travel expenses and honoraria for lectures and educational activities not funded by industry
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Medtronics
Period Title Source Role Total Amount 6/1/17-5/31/18 9/19/16-9/18/18 12/1/16-11/30/18 6/1/16-5/31/17 Reactive responses and locomotor adjustments after concussion Direct to Phase II: A Wearable System for Assessment of Fall Risk Associated with Cancer Treatment HOME: Monitoring Balance and Gait with the Home Objective Mobility Exam Dyskinesia Effects on Postural Stability During Turning MRF NCI NIH SBIR MRF Mentor Co-PI Co-PI Mentor $19,991 $1,457,489 $1,657,649 $20,000 6/1/16-5/31/17 Relationships between Fatigue, Histidine and Proinflammatory Cytokinesin MRF Mentor $20,000 3/1/16-2/28/17 The Turning Point: Dynamic Stability in People with Parkinson?s Disease MRF Mentor $20,000 9/1/16-8/31/17 Motor Fatigue in People with Multiple Sclerosis and Implications for Balance Control MRF Mentor $20,000 9/30/16-5/31/19 Mobility Life: Monitoring Mobility in Daily Lived of People with Neurological Disease NIH STTR PI $733,883 9/30/16-8/30/17 Mobility Rehab: A Biofeedback System for Mobility Rehabilitation for Older Adults NIA Consult. $298,697 2/24/12-1/31/17 Preventing Falls after Cancer: Tai Chi vs. Strength NIA NCI Co-I $390,731 5/15/14-3/31/19 Peripheral & Central Postural Disorders in the Elderly NIA-NIH MERIT PI $3,156,945 1/1/13-12/31/17 Frontal Cortex and Gait Freezing in Parkinson?s Disease: Rehabilitation Impact VA RR&D Merit Review PI $1,097,269 4/1/14-3/31/18 The Instrumented Stand and Walk Test (ISAW) STTR Phase II: NIH/CHHD/NCMRR PI $1,400,315 7/1/14-6/30/17 Effects of Augmenteing Cholinergic Function on Gait and Balance MJFF Co-I $160,175 4/1/14-3/31/17 Identification of Gait and Blance Deficits in Patients with MS Using Wireless Sensors NMSS Sub-I $158,134 8/1/15-7/31/20 PANUC: Balance & Gait Disorders in PD Associated with Genetic Inheritance in PD NINDS PI $1,952,761 7/1/14-6/30/17 Effects of Surface Pertubations on Changes in Postural Responses in People with Multiple Sclerosis NMSS Mentor $155,872 7/1/14-6/30/17 A Short Instrumented Test of Mobility for Neurological Disorders: Phase II NIH/CHHD/NCMRR PI $699,927 7/1/14-6/30/19 Rehabilitation Research Training in Postural Control of Multiple Sclerosis NMSS PI $432,457 10/1/15-9/30/19 Assessment and Rehabilitation of Central Sensory Impairments for Balance in mTBI US Army MRAA Co-I $2,000,00
Fellowship in Rehabilitation for Multiple Sclerosis National MS Society, PI, 7/1/09-2017
Medical Research Foundation of Oregon
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APDM, Inc, privately held
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- Jack Simon, MD, PhD and
1. Biogen-Idec
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Imaging Acute Neurologic Disease: A symptom Based Approach. M. Filippi and Jack H Simon. Cambridge University Press. 2014.
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1. Biogen-Idec (Commercial) 2. Guthy-Jackson Charitable Foundation (non-profit)
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- Dennis Bourdette, MD
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(1) National Multiple Sclerosis Society, funding for travel (2) Consortium of MS Centers, funding for travel (3) Paralyzed Veterans of America, funding for travel
(1) Neurology, Member Editorial Board, 2013-present
(1) Use patent for the treatment of multiple sclerosis with cyclic peptide derivatives of cyclosporin (2) Patent pending for thyromimetic drugs for stimulating remyelination in multiple sclerosis.
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(1) I provide consultations to Magellan Health on individual cases regarding requests to insurance companies for coverage of expensive therapies (2) I provide patient consultations for Best Doctors, Inc.
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(1) National MS Society, PI, April 2015- present (2) National MS Society, PI, April 2015-present
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- From the Neurology Division (R.S., V.Y., M.C., E.K., D.B.), Research Service (K.P., E.H.), and Department of Ophthalmology (K.W.), Veterans Affairs Portland Health Care System, OR; and Department of Neurology (R.S., C.M., K.W., V.Y., E.K., F.H., J.S., D.B.), Advanced Imaging Research Center (K.P.), and Casey Eye Institute (K.W.), Oregon Health & Science University, Portland.
- Correspondence to Dr. Spain: spainr{at}ohsu.edu
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