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September 2017; 4 (5) ArticleOpen Access

Lipoic acid in secondary progressive MS

A randomized controlled pilot trial

Rebecca Spain, Katherine Powers, Charles Murchison, Elizabeth Heriza, Kimberly Winges, Vijayshree Yadav, Michelle Cameron, Ed Kim, Fay Horak, Jack Simon, Dennis Bourdette
First published June 28, 2017, DOI: https://doi.org/10.1212/NXI.0000000000000374
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Article Information

vol. 4 no. 5 e374
DOI: 
https://doi.org/10.1212/NXI.0000000000000374
PubMed: 
28680916
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Online ISSN: 
2332-7812
History: 
  • Received March 7, 2017
  • Accepted in final form May 15, 2017
  • First Published June 28, 2017.
Copyright & Usage: 
Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Author Disclosures

    1. Rebecca Spain, MD, MSPH,
    2. Katherine Powers, BA, CCRP,
    3. Charles Murchison, MS,
    4. Elizabeth Heriza, MD,
    5. Kimberly Winges, MD,
    6. Vijayshree Yadav, MD, MSCR,
    7. Michelle Cameron, MD, PT,
    8. Ed Kim, MD,
    9. Fay Horak, PhD, PT,
    10. Jack Simon, MD, PhD and
    11. Dennis Bourdette, MD
  1. Rebecca Spain, MD, MSPH,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Department of Veterans Affairs, B7493-W, 2010-2015 Oregon Clinical and Translational Research Institute, (UL1TR000128), 2010-2015

    Research Support, Academic Entities:

    1. 1. VA Portland Health Care System 2. Oregon Health & Science University

    Research Support, Foundations and Societies:

    1. National MS Society Conrad Hilton FOundation Medical Research Foundation of Oregon Race to Erase MS

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Katherine Powers, BA, CCRP,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Charles Murchison, MS,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Elizabeth Heriza, MD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Kimberly Winges, MD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Vijayshree Yadav, MD, MSCR,
    7. Scientific Advisory Boards:

    1. (1) Genentech

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Consultant - Bayer's Advisory meeting Consultant - Biogen National Advisory Committee Consultant - Teva MS Medical Advisory board meeting

    Speakers' Bureaus:

    1. Novartis Inc. Biogen Idec

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1)Biogen Idec

    Research Support, Government Entities:

    1. (1) Department of Veterans Affairs, 3427, Primary Investigator, 4

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) McDougall Foundation, Research grant funding (2) National MS Society (3) Race to Erase MS Foundation (5) National Institute of Health

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Michelle Cameron, MD, PT,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. I have received compensation for travel from the Consortium of Multiple Sclerosis Centers and the VA Portland Research Foundation.

    Editorial Boards:

    1. I am an editorial advisory board member with no compensation for the Journal of Hand Therapy and an editor for the section on demyelinating disorders with no compensation for Nature Reviews Neuroscience.

    Patents:

    1. NONE

    Publishing Royalties:

    1. I receive publishing royalties for the following books: (1) Physical Agents in Rehabilitation: From Research to Practice 4th edition; Elsevier, 2012 (2) Physical Rehabilitation; Elsevier, 2009 (3) Physical Rehabilitation for the Physical Therapist Assistant; Elsevier, 2010

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. I provide consultation to (1) Re-walk corporation (2) Adamas corporation

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. I have received research support from: (1) the Department of Veterans Affairs, Rehabilitation Research and Development Service

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. I have received research support from (1) National MS Society (2) Paralyzed Veterans of America Foundation.

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Ed Kim, MD,
    9. Scientific Advisory Boards:

    1. I served on an advisory boards once for both Genzyme and Teva Pharmaceutical within the past 2 years.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1) National MS Society; Multicenter Randomized Clinical Trial of high dose vs low dose vitamin D.

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. Fay Horak, PhD, PT,
    10. Scientific Advisory Boards:

    1. MS Society, Grant Reviewer, 2010-2016 APDM,Inc, Co-owner and employee NIH NCMRR Advisory Council, 2015-2017

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Received travel expenses and honoraria for lectures and educational activities not funded by industry

    Editorial Boards:

    1. (1) Gait and Posture, Senior Assoc Editor 1993-2006, Board 2008-2017 (2)Cerebellum, Assoc Editor, 2001-2015 (3) J of Biomechanics, Editorial Board, 2008-present (4) Encyclopedia for Neuroscience, Associate Editor, 2005-7 (5) Frontiers in Neurology, Editorial Board, 2015-17 (6) Frontiers in Neuro-otoloyg, Editorial Board, 2010-2017

    Patents:

    1. 1) Devise for conditioning balance and motor coordination European Patent No 04736776.8 2) Instrumented Mobility System to objectively measure Balance and Gait, US patent pending

    Publishing Royalties:

    1. Chapter 39, Posture Control in Kandel and Schwartz, 4th Editor, Principles of Neuroscience, McGraw-Hill, 2000-2017

    Employment, Commercial Entity:

    1. Received travel expenses and honoraria for lectures and educational activities not funded by industry

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Medtronics

    Research Support, Government Entities:

    1. Period Title Source Role Total Amount 6/1/17-5/31/18 9/19/16-9/18/18 12/1/16-11/30/18 6/1/16-5/31/17 Reactive responses and locomotor adjustments after concussion Direct to Phase II: A Wearable System for Assessment of Fall Risk Associated with Cancer Treatment HOME: Monitoring Balance and Gait with the Home Objective Mobility Exam Dyskinesia Effects on Postural Stability During Turning MRF NCI NIH SBIR MRF Mentor Co-PI Co-PI Mentor $19,991 $1,457,489 $1,657,649 $20,000 6/1/16-5/31/17 Relationships between Fatigue, Histidine and Proinflammatory Cytokinesin MRF Mentor $20,000 3/1/16-2/28/17 The Turning Point: Dynamic Stability in People with Parkinson?s Disease MRF Mentor $20,000 9/1/16-8/31/17 Motor Fatigue in People with Multiple Sclerosis and Implications for Balance Control MRF Mentor $20,000 9/30/16-5/31/19 Mobility Life: Monitoring Mobility in Daily Lived of People with Neurological Disease NIH STTR PI $733,883 9/30/16-8/30/17 Mobility Rehab: A Biofeedback System for Mobility Rehabilitation for Older Adults NIA Consult. $298,697 2/24/12-1/31/17 Preventing Falls after Cancer: Tai Chi vs. Strength NIA NCI Co-I $390,731 5/15/14-3/31/19 Peripheral & Central Postural Disorders in the Elderly NIA-NIH MERIT PI $3,156,945 1/1/13-12/31/17 Frontal Cortex and Gait Freezing in Parkinson?s Disease: Rehabilitation Impact VA RR&D Merit Review PI $1,097,269 4/1/14-3/31/18 The Instrumented Stand and Walk Test (ISAW) STTR Phase II: NIH/CHHD/NCMRR PI $1,400,315 7/1/14-6/30/17 Effects of Augmenteing Cholinergic Function on Gait and Balance MJFF Co-I $160,175 4/1/14-3/31/17 Identification of Gait and Blance Deficits in Patients with MS Using Wireless Sensors NMSS Sub-I $158,134 8/1/15-7/31/20 PANUC: Balance & Gait Disorders in PD Associated with Genetic Inheritance in PD NINDS PI $1,952,761 7/1/14-6/30/17 Effects of Surface Pertubations on Changes in Postural Responses in People with Multiple Sclerosis NMSS Mentor $155,872 7/1/14-6/30/17 A Short Instrumented Test of Mobility for Neurological Disorders: Phase II NIH/CHHD/NCMRR PI $699,927 7/1/14-6/30/19 Rehabilitation Research Training in Postural Control of Multiple Sclerosis NMSS PI $432,457 10/1/15-9/30/19 Assessment and Rehabilitation of Central Sensory Impairments for Balance in mTBI US Army MRAA Co-I $2,000,00

    Research Support, Academic Entities:

    1. Fellowship in Rehabilitation for Multiple Sclerosis National MS Society, PI, 7/1/09-2017

    Research Support, Foundations and Societies:

    1. Medical Research Foundation of Oregon

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. APDM, Inc, privately held

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. Jack Simon, MD, PhD and
    11. Scientific Advisory Boards:

    1. 1. Biogen-Idec

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. Imaging Acute Neurologic Disease: A symptom Based Approach. M. Filippi and Jack H Simon. Cambridge University Press. 2014.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. 1. Biogen-Idec (Commercial) 2. Guthy-Jackson Charitable Foundation (non-profit)

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  11. Dennis Bourdette, MD
    12. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (1) National Multiple Sclerosis Society, funding for travel (2) Consortium of MS Centers, funding for travel (3) Paralyzed Veterans of America, funding for travel

    Editorial Boards:

    1. (1) Neurology, Member Editorial Board, 2013-present

    Patents:

    1. (1) Use patent for the treatment of multiple sclerosis with cyclic peptide derivatives of cyclosporin (2) Patent pending for thyromimetic drugs for stimulating remyelination in multiple sclerosis.

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) I provide consultations to Magellan Health on individual cases regarding requests to insurance companies for coverage of expensive therapies (2) I provide patient consultations for Best Doctors, Inc.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) National MS Society, PI, April 2015- present (2) National MS Society, PI, April 2015-present

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Neurology Division (R.S., V.Y., M.C., E.K., D.B.), Research Service (K.P., E.H.), and Department of Ophthalmology (K.W.), Veterans Affairs Portland Health Care System, OR; and Department of Neurology (R.S., C.M., K.W., V.Y., E.K., F.H., J.S., D.B.), Advanced Imaging Research Center (K.P.), and Casey Eye Institute (K.W.), Oregon Health & Science University, Portland.
  1. Correspondence to Dr. Spain: spainr{at}ohsu.edu
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