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January 2018; 5 (1) ArticleOpen Access

Covertly active and progressing neurochemical abnormalities in suppressed HIV infection

Lucette A. Cysique, Lauriane Jugé, Thomas Gates, Michael Tobia, Kirsten Moffat, Bruce J. Brew, Caroline Rae
First published January 3, 2018, DOI: https://doi.org/10.1212/NXI.0000000000000430
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Article Information

vol. 5 no. 1 e430
DOI: 
https://doi.org/10.1212/NXI.0000000000000430
PubMed: 
29312999
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Online ISSN: 
2332-7812
History: 
  • Received July 23, 2017
  • Accepted in final form October 10, 2017
  • First Published January 3, 2018.
Copyright & Usage: 
Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Author Disclosures

    1. Lucette A. Cysique, PhD,
    2. Lauriane Jugé, PhD*,
    3. Thomas Gates, MA (Clin Neuropsychol)*,
    4. Michael Tobia, BA Sc (Hons),
    5. Kirsten Moffat, BA AppSc (MRT),
    6. Bruce J. Brew, MBBS (Hons), MD, FRACP, FAAN† and
    7. Caroline Rae, PhD†
  1. Lucette A. Cysique, PhD,
    2. Scientific Advisory Boards:

    1. 1. one NIH funded study

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. The Journal of Aids & Clinical Research ? Open access, Editorial Board Member, 3 years The Journal of Sexually Transmitted Diseases, Editorial Board Member, 3 years The World Jounal of Neurology, Editorial Board Member, 2 years Biomed Research International, 2 years Plos One 2 years

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Gilead science fellowship award

    Research Support, Government Entities:

    1. (1) NHMRC Career Development Fellowship APP1045400 PI, 2013-2018

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Lauriane Jugé, PhD*,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. The Rebecca L Cooper Medical Research Foundation Ltd

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Thomas Gates, MA (Clin Neuropsychol)*,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Michael Tobia, BA Sc (Hons),
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Kirsten Moffat, BA AppSc (MRT),
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Bruce J. Brew, MBBS (Hons), MD, FRACP, FAAN† and
    7. Scientific Advisory Boards:

    1. GlaxoSmithKline, member 2008- BiogenIdec, member 2007- ViiV Healthcare, member 2010 Merck Serono, member 2010

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Abbott for CROI meeting 2010 Viiv for CROI 2011

    Editorial Boards:

    1. International Journal for Tryptophan Research, member 2008- Faculty of 1000 Medicine member 2008- Journal of Neurovirology, member 2009- Neurobehavioral HIV Medicine, member 2009- AIDS 2017-

    Patents:

    1. NONE

    Publishing Royalties:

    1. HIV Neurology Oxford University Press, 2001 Palliative Neurology (Cambridge University Press, 2006

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. GlaxoSmithKline, speaker, 2005-2009 ViiV Healthcare, 2010, 2016 Boehringer Ingelheim, 2005-2010 Abbott, 2009-2010, 2015 Biogen Idec 2006, 2008 Novartis 2017

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Eli Lilly 2009-2010 GlaxoSmithKline, 2009 ViiV Healthcare, 2010 Merck Serono, 2010 Biogen Idec 2015

    Research Support, Government Entities:

    1. National Health and Medical Research Council (NHMRC) of Australia, #358399, PI 2005-2010, and #1105808 PI 2015, National Institute of Mental Health and National Institute of Neurological Disorders and Stroke, grant number 1U01-AI068641, 2009-2016, co-PI

    Research Support, Academic Entities:

    1. University of New South Wales 2001- University of Notre Dame Sydney, 2014-

    Research Support, Foundations and Societies:

    1. St Vincent's Clinic Research Foundation 2009, 2010

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Caroline Rae, PhD†
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Philips Healthcare, travel costs

    Editorial Boards:

    1. Neurochemical Research, Associate Editor, 2016-

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Australian Research Council LE170100021 CI, 2016 NSW Government, RAAP, 2015-2017

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the School of Medical Sciences (L.A.C., L.J., M.T., C.R.), Faculty of Medicine, UNSW Australia, Sydney; Neuroscience Research Australia (L.A.C., L.J., C.R.), Randwick; Peter Duncan Neuroscience Research Unit (L.A.C., T.G., B.J.B.), St. Vincent's Applied Medical Research Center, Darlinghurst; and St. Vincent's Hospital Sydney (L.A.C., T.G., K.M., B.J.B.), Darlinghurst, New South Wales, Australia.
  1. Correspondence
    Dr. Cysique: lcysique{at}unsw.edu.au
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