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May 2018; 5 (3) Clinical/Scientific NotesOpen Access

Effective treatment of CLIPPERS with long-term use of rituximab

Veronica P. Cipriani, Nancy Arndt, Peter Pytel, Anthony T. Reder, Adil Javed
First published March 1, 2018, DOI: https://doi.org/10.1212/NXI.0000000000000448
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Article Information

vol. 5 no. 3 e448
DOI: 
https://doi.org/10.1212/NXI.0000000000000448
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Online ISSN: 
2332-7812
History: 
  • Received December 6, 2017
  • Accepted in final form January 17, 2018
  • First Published March 1, 2018.
Copyright & Usage: 
Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Author Disclosures

    1. Veronica P. Cipriani, MD,
    2. Nancy Arndt, RN, MSCN,
    3. Peter Pytel, MD,
    4. Anthony T. Reder, MD and
    5. Adil Javed, MD, PhD
  1. Veronica P. Cipriani, MD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. National MS Society

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Nancy Arndt, RN, MSCN,
    3. Scientific Advisory Boards:

    1. 1.)Genzyme 3.)Bayer

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. 1.)Genzyme 2.)Teva

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. 1.)Genzyme 2.)Teva

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Peter Pytel, MD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Editorial board of Modern Pathology

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIA funding as co-investigator for unrelated studies on myopathies.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. Acted as expert witness for an law firm

  4. Anthony T. Reder, MD and
    5. Scientific Advisory Boards:

    1. (1) Abbott, ImmunoScience, Inc., (2) Questcor/Malinkrodt, (3) AstraZeneca, (4)Merck Serono, (5) Athena Diagnostics, Inc., (6) Sanofi-Aventis, (7) Bayer, (8) Biogen Idec, (9) BioMS Medical, (10) Blue Cross Blue Shield, (11) Boehringer Ingelheim, (12) Caremark Rx, (13) Centocor Ortho Biotech Inc., (14) Cephalon, Inc., (15) Connetics Corp., (16) CroMedica Global Inc., (17) Eli Lilly and Company, (18) Elan Corporation, (19) Genentech, Inc., (20) Genzyme Corporation, (21) GlaxoSmithKline, (22) Hoechst Marion Roussel Canada Research, Inc., (23) Roche, (24) Immunex Corporation, (25) Institute for Health Care Quality, (26) Johnson & Johnson, (27) Yale University, (28) Barrow Neurological Institute, (29) National Multiple Sclerosis Society & Paralyzed Veterans of America, (30) Neurocrine Biosciences, (31) Novartis, (32) Parke-Davis, (33) Pfizer Inc., (34) Pharmacia & Upjohn, (35) Protein Design Labs, Inc., (36) Quantum Biotechnologies, Inc., (37) Quintiles, Inc., (38) EMD Serono, Inc., (39 Sention, Inc., (40) Smith Kline- Beecham, (41) Specialized Therapeutics (a division of Berlipharm, Inc.), (42) Takeda Pharmaceutical Company Limited, (43) Teva Pharmaceutical Industries Ltd.

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (1) Abbott, ImmunoScience, Inc., (2) Questcor/Malinkrodt, (3) AstraZeneca, (4)Merck Serono, (5) Athena Diagnostics, Inc., (6) Sanofi-Aventis, (7) Bayer Schering Pharma, (8) Biogen Idec, (9) BioMS Medical, (10) Blue Cross Blue Shield, (11) Boehringer Ingelheim, (12) Caremark Rx, (13) Centocor Ortho Biotech Inc., (14) Cephalon, Inc., (15) Connetics Corp., (16) CroMedica Global Inc., (17) Eli Lilly and Company, (18) Elan Corporation, (19) Genentech, Inc., (20) Genzyme Corporation, (21) GlaxoSmithKline, (22) Hoechst Marion Roussel Canada Research, Inc., (23) Roche, (24) Immunex Corporation, (25) Institute for Health Care Quality, (26) Johnson & Johnson, (27) Yale University, (28) Barrow Neurological Institute, (29) National Multiple Sclerosis Society & Paralyzed Veterans of America, (30) Neurocrine Biosciences, (31) Novartis, (32) Parke-Davis, (33) Pfizer Inc., (34) Pharmacia & Upjohn, (35) Protein Design Labs, Inc., (36) Quantum Biotechnologies, Inc., (37) Quintiles, Inc., (38) EMD Serono, Inc., (39 Sention, Inc., (40) Smith Kline- Beecham, (41) Specialized Therapeutics (a division of Berlipharm, Inc.), (42) Takeda Pharmaceutical Company Limited, (43) Teva Pharmaceutical Industries Ltd.

    Editorial Boards:

    1. (1) Medlink/Neurobase Editorial Board, Arbor Publishing Corporation, San Diego, CA, 1999-Present; (2) Turkish Journal of Medical Sciences, Editorial Board, 2001- present; (3) T?rk N?roloji Dergisi (Turkish Journal of Neurology), Editorial Board, 2004-present

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Abbott, (2) Questcor/Malinkrodt,(3) AstraZeneca, (4) Merck Serono, (5) Athena Diagnostics, Inc., (6) Sanofi- Aventis, (7) Bayer Schering Pharma, (8) Biogen Idec, (9) BioMS Medical, (10) Blue Cross Blue Shield, (11) Boehringer Ingelheim, (12) Caremark Rx, (13) Centocor Ortho Biotech Inc., (14) Cephalon, Inc., (15) Connetics Corp., (16) CroMedica Global Inc., (17) Eli Lilly and Company, (18) Elan Corporation, (19) Genentech, Inc., (20) Genzyme Corporation, (21) GlaxoSmithKline, (22) Hoechst Marion Roussel Canada Research, Inc., (23) Roche, (24) Immunex Corporation, (25) Institute for Health Care Quality, (26) Johnson & Johnson, (27) Yale University, (28) Barrow Neurological Institute, (29) National Multiple Sclerosis Society & Paralyzed Veterans of America, (30) Neurocrine Biosciences, (31) Novartis, (32) Parke-Davis, (33) Pfizer Inc., (34) Pharmacia & Upjohn, (35) Protein Design Labs, Inc., (36) Quantum Biotechnologies, Inc., (37) Quintiles, Inc., (38) EMD Serono, Inc., (39 Sention, Inc., (40) Smith Kline- Beecham, (41) Specialized Therapeutics (a division of Berlipharm, Inc.), (42) Takeda Pharmaceutical Company Limited, (43) Teva Pharmaceutical Industries Ltd.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Novartis, (2) Bayer, (3) Serono, Inc., (4) Chugai, (5) Genzyme,(6) Biogen Idec, (7)Medimmune (8) Genentech/Roche, Inc., (8) Medday

    Research Support, Government Entities:

    1. (1) NIH/NINDS RO1 NS 051591, Site PI; (2) NIH 1 K24 RR021948, PI. (2) Chinese Government, (3) Turkish Ministry of Defense Fellowship Award, (4) the State of Illinois

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) the National MS Society, (2) the Brain Research Foundation, (3) the American Academy of Allergy & Immunology, (4) Howard Hughes Foundation, (5) Egypt Arab Republic Peace Fellowship,

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Adil Javed, MD, PhD
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Dr. Javed has been a consultant for Biogen, Sanofi- Genzyme, Serono, Mallinckrodt, and Genentech.

    Speakers' Bureaus:

    1. Dr. Javed serves on the speaker's bureau for Biogen, Sanofi-Genzyme, Serono, Teva, Mallinckrodt, and Genentech.

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Department of Neurology (V.P.C., N.A., A.T.R., A.J.), and Department of Pathology (P.P.), University of Chicago, IL.
  1. Correspondence
    Dr. Cipriani vpenyak{at}gmail.com
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