Article Figures & Data
Figures
- Figure 1 Example OCT scan
(A) Optical coherence tomography B-scan with segmentation lines generated from the mean of all 5 raters with color-coded SD between raters (1 pixel ≙ 3.78 μm). Shown are the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), and outer nuclear layer (ONL). For analysis, the GCL and IPL were also segmented as a compound layer (GCIP). In the example B-scan, the segmentation lines with higher levels of disagreement between raters (indicated by higher SDs) are the IPL, the area of the fovea, and segmentation lines crossing blood vessel artifacts. (B) Example thickness map of the GCIP on the fundus image. The mean of all thickness values within the 6-mm ETDRS circle (white circle) was used for analysis. GCIP = ganglion cell inner plexiform layer.
- Figure 2 Intraretinal layer thickness measurements
Boxplots for different retinal layer thicknesses of OCT scans from all 17 subjects corrected by all 5 raters (Hospital Clínic de Barcelona [HCB]; NeuroCure Clinical Research Center [NCRC], Berlin; University of California, San Francisco [UCSF]; University Hospital Zürich [USZ]; and VU University Medical Center [VUMC], Amsterdam). The dots represent outliers. GCIP = ganglion cell inner plexiform layer; GCL = ganglion cell layer; INL = inner nuclear layer; IPL = inner nuclear layer; ONL = outer nuclear layer; OPL = outer plexiform layer; RNFL = retinal nerve fiber layer.
- Figure 3 Local intraclass correlation coefficients
Color-coded interclass correlation coefficients (ICCs) for the manually corrected intraretinal layer segmentation across all positions in macular volume scans (1024 A-scans and 25 B-scans). Seven different intraretinal layers were assessed (A-G): retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), combined GCL and IPL (GCIP), inner nuclear layer (INL), outer plexiform layer (OPL), and outer nuclear layer (ONL). The central foveal scan and peripheral areas outside the ETDRS macular volume are predilection sites of disagreement. GCIP = ganglion cell inner plexiform layer.
- Figure 4 Differences between semiautomatic and fully automatic segmentation
Boxplots show the differences between automated and manually corrected segmentation for the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), combined ganglion cell and inner plexiform layer (GCIP), inner nuclear layer (INL), outer plexiform layer (OPL), and outer nuclear layer (ONL). Manual correction had the biggest influence on the outer layers (difference of up to ca. −10 μm) and less pronounced influence on the inner layers. The stars represent outliers.
Tables
Letters: Rapid online correspondence
- RE: Multicenter reliability of semiautomatic retinal layer segmentation using OCT
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