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January 2019; 6 (1) ArticleOpen Access

CSF concentrations of soluble TREM2 as a marker of microglial activation in HIV-1 infection

Magnus Gisslén, Amanda Heslegrave, Elena Veleva, Aylin Yilmaz, Lars-Magnus Andersson, Lars Hagberg, Serena Spudich, Dietmar Fuchs, Richard W. Price, Henrik Zetterberg
First published November 7, 2018, DOI: https://doi.org/10.1212/NXI.0000000000000512
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Article Figures & Data

Figures

  • Figure 1
    Figure 1 Concentrations of CSF biomarkers in the 7 participant groups

    The figure shows concentrations of CSF sTREM2 (A), CSF neopterin (B), and age-adjusted CSF NFL (C) in the 7 participant groups. Boxes in all panels depict median and IQR, whiskers show 10–90 percentiles, and “+” designates the mean values. Gray horizontal lines show the upper limit of normal. Statistical comparisons of groups are given in table 2. Measured markers are listed in the title of each panel and findings described in the text.

  • Figure 2
    Figure 2 Correlations between CSF biomarkers and age

    The figure shows correlations between CSF sTREM2, neopterin, and NFL (A–C). Regression lines and Pearson correlation coefficient are shown in each panel. Associations between CSF biomarkers and age (D–F). Regression lines and Pearson correlation coefficient are shown in panel D and F. No significant correlation was found between CSF neopterin and age (E). NFL = neurofilament light protein.

  • Figure 3
    Figure 3 CSF sTREM2 in HIV-negative controls

    (A) A strong correlation between CSF sTREM2 and CSF NFL was found in HIV-negative controls (n = 11). (B) Both CSF sTREM2 and NFL increase with age in healthy controls. NFL = neurofilament light protein.

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  • Table 2
  • Table 3

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