Disease-modifying therapies alter gut microbial composition in MS
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Article Information
- Received June 6, 2018
- Accepted in final form September 10, 2018
- First Published October 26, 2018.
Author Disclosures
- Ilana Katz Sand, MD*,
- Yunjiao Zhu, PhD*,
- Achilles Ntranos, MD,
- Jose C. Clemente, PhD,
- Egle Cekanaviciute, PhD,
- Rachel Brandstadter, MD,
- Elizabeth Crabtree-Hartman, MD,
- Sneha Singh, BSc,
- Yadira Bencosme, MPH,
- Justine Debelius, PhD,
- Rob Knight, PhD,
- Bruce A.C. Cree, MD, PhD, MAS,
- Sergio E. Baranzini, PhD and
- Patrizia Casaccia, MD, PhD
- Ilana Katz Sand, MD*,
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1) United States Department of Defense, Project Number MS140072P1, Award Number W81XWH-15-1-0449, Co-PI, 2015- 2018 2) United States Department of Defense, Project Number MS140059, Award Number W81XWH-15-1-0652, Co-I, 2015-2018
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1) National Multiple Sclerosis Society 2) Guthy Jackson Charitable Foundation
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- Yunjiao Zhu, PhD*,
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- Achilles Ntranos, MD,
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- Jose C. Clemente, PhD,
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Microbiome, associate editor, 2017-present mBio, editor, 2015-present
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- Egle Cekanaviciute, PhD,
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NIH IRACDA post-doctoral fellowship (UCSF STRIDE program), post- doctoral scholar, 2014-2017
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- Rachel Brandstadter, MD,
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- Elizabeth Crabtree-Hartman, MD,
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I received speaker honoraria from Biogen Idec and Genzyme Sanofi
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Teva, Novartis, Biogen
(1) Teva Neuroscience, Biogen
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- Sneha Singh, BSc,
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- Yadira Bencosme, MPH,
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(1) Novo Nordisk, Inc., 9 months (2) Icahn School of Medicine at Mount Sinai, 12 years
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- Justine Debelius, PhD,
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(1) University of California, San Diego (La Jolla, CA)
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- Rob Knight, PhD,
(1) Janssen (2) CommenSe (3) Prometheus
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(1) Metagenics, funding for travel to speak at conference (2) Genentech, funding for travel to speak at conference (3) Zurich Insurance Co, funding for travel to speak at conference
(1) BiologyDirect, Editorial Board Member, 2006-present (2) Gut Microbes, Editorial Board Member, 2011-present (3) AEM, Editorial Board Member, 2011-present (4) Env Micro, Editorial Board Member, 2011-present (5) Genome Biology, Editorial Board Member, 2011-present (6) ISME J, Editor, 2011-present
(1)MICROBIOME BASED SYSTEMS, APPARATUS AND METHODS FOR MONITORING AND CONTROLLING INDUSTRIAL PROCESSES AND SYSTEMS (2) MICROBIOME BASED SYSTEMS, APPARATUS AND METHODS FOR THE EXPLORATION AND PRODUCTION OF HYDROCARBONS
(1) Follow Your Gut: The Enormous Impact of Tiny Microbes, Simon and Schuster, 2015 (2) Dirt Is Good: The Advantage of Germs for Your Child's Developing Immune System, St. Martin's Press, 2017
(1) Biota Technology, Inc., Chief Scientific Officer, 2014-present
(1) CommenSe (2) Prometheus
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(1) Janssen (Johnson & Johnson)
(1) NIH NIDDK, P01DK078669, co-PI, 2015-2019 (2) NIH NIAID, U19AI113048, co-PI, 2015-2019 (3) DOJ,1553430 2015-DN-BX-K016, co-PI, 2016-2018 (4) ONR, 1553360 N00014-15-1-2809, co-PI, 2015-2020 (5) USAMRAA, W81XWH-15-1-0653, PI, 2015-2018 (6) NSF, DBI-1565057, PI, 2016-2019 (7) NIAID/NIH, U01AI24316, co-PI, 2016-2021 (8) NIH, P30MH062512, co-PI, 2016-2021 (9) NIH, 31106A 5R01MD011389-02, co-PI, 2016-2021 (10) NIH-NHLBI, 1554895 RHL134887A, co-PI, 2017-2020 (11) NIH-NIDDK, 92129430 R01DK110793, co-PI, 2017-2021 (12) DOJ, G-75544-01 2016-DN-BX-4194, co-PI, 2017-2018 (13) NIH , 311257 R01HL140976 , co-PI, 2018-2021 (14) NIH-NIDDK, 1R01DK110793-01A1, co-PI, 2017-2018 (15) DOJ, 2014-R2-CX-K411, PI, 2015-2017 (16) NIH, 1U54DE023789-01, co-PI, 2013-2017
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(1) LAUREATE INSTITUTE FOR BRAIN RESEARCH (2) Alfred P. Sloan Foundation (3) Gerber Foundation (4) CRISP (5) ROBERT WOOD JOHNSON FOUNDATION
(1) Biota Technology, Inc.
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- Bruce A.C. Cree, MD, PhD, MAS,
- Sergio E. Baranzini, PhD and
Novartis, Ad-board EMD Serono, Ad-board Sanofi-Aventis, Ad-Board
Novartis Pharma
Novartis, travel and speaker honorarium
Multiple Sclerosis Journal, Editorial Board member, 5 years Neurology, Editorial board member, 5 years mSystems Editorial board member, 2 years
A patent on a gene expression signature that could identify patients at high risk of developing MS is currently pending.
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Novartis EMD Serono TEVA Neuroscience
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NIH/NINDS, R01NS088155 (PI), 2014-2019 NIH/NINDS, R01NS099240 (PI), 2017-2021 Department of Defense DOD_W81XWH-15-1-0652 (PI)
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NMSS (Collaborative Award), CA_1072-A-7 2015-2020
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- Patrizia Casaccia, MD, PhD
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Department of The Army W81XWH-15-1-0652
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National Multiple Sclerosis Society CA-1072_A7
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- From the Department of Neurology (I.K.S., A.N., R.B., Y.B.), Department of Neuroscience (Y.Z., P.C.), and Department of Genetics & Genomic Sciences, Icahn Institute for Genomics & Multiscale Biology (J.C.C.), Icahn School of Medicine at Mount Sinai; Department of Neurology (E.C., E.C.-H., S.S., B.A.C.C., S.E.B.), Weill Institute for Neurosciences, University of California, San Francisco; E.C. is now with Universities Space Research Association, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA; Department of Pediatrics (J.D., R.K.), Department of Computer Science & Engineering (R.K.), and Center for Microbiome Innovation (R.K.), University of California, San Diego; and Neuroscience Initiative (P.C.), Advanced Research Science Center at the Graduate Center of the City University of New York.
- Correspondence
Dr. Katz Sand ilana.katzsand{at}mssm.edu
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