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January 2019; 6 (1) ArticleOpen Access

Circulating inflammatory biomarkers are related to cerebrovascular disease in older adults

Yian Gu, Jose Gutierrez, Irene B. Meier, Vanessa A. Guzman, Jennifer J. Manly, Nicole Schupf, Adam M. Brickman, Richard Mayeux
First published November 14, 2018, DOI: https://doi.org/10.1212/NXI.0000000000000521
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Article Information

vol. 6 no. 1 e521
DOI: 
https://doi.org/10.1212/NXI.0000000000000521
PubMed: 
30568999
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Online ISSN: 
2332-7812
History: 
  • Received March 28, 2018
  • Accepted in final form October 12, 2018
  • First Published November 14, 2018.
Copyright & Usage: 
Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Author Disclosures

    1. Yian Gu, PhD,
    2. Jose Gutierrez, MD, MPH,
    3. Irene B. Meier, PhD,
    4. Vanessa A. Guzman, MS,
    5. Jennifer J. Manly, PhD,
    6. Nicole Schupf, PhD,
    7. Adam M. Brickman, PhD and
    8. Richard Mayeux, MD
  1. Yian Gu, PhD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. I received travel reimbursement from California Walnut Commission for my travel expenses to present a poster at Organization for Human Brain Mapping conference in June 2017. The project title is

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Supported by NIH AG042483.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Jose Gutierrez, MD, MPH,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. PLOS One, reviewer editor, 1 year Frontiers Neurology, reviewer editor, 1 year

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. Medico-legal consultancies

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIA, AG054023, Co-I, year 2 NINDS, NS029993, Co-I, year 2

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. medical cases litigation

  3. Irene B. Meier, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) Synapsis Foundation - Alzheimer Forschung Schweiz (2) VELUX Stiftung

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Vanessa A. Guzman, MS,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. I have received a predoctoral research training grant: NIH F31-MD011582 (PI: V. Guzman) 08/2017 ? 07/2019 National Institute on Minority Health and Health Disparities (NIMHD) Project Tile: The longitudinal effects of hypertension on cognitive aging in underrepresented minority adults with HIV. Role: Principal Investigator

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Jennifer J. Manly, PhD,
    6. Scientific Advisory Boards:

    1. Reimbursement of travel costs and AAIC registration associated with serving on the Medical and Scientific Advisory Board of the Alzheimer's Association

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Journal of the International Neuropsychological Society, associate editor, 2005 - 2014

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. National Academies of Medicine - 2014 and 2017 National Academy of Sciences, 2018

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NIA R01AG016495, co-investigator, 09/15/2012- 06/30/2017 (2) NIDDK U01DK098246, co-investigator, 12/01/2012- 7/31/2017 (3) NIA R56AG034189, co-investigator, 09/01/2016 ? 08/31/2017 (4) NINDS U01NS041588, co-investigator, 09/01/2001- 11/30/2017 (5) NIA R00AG47963, co-investigator, 09/01/2016- 08/31/2019 (6) NIA U01AG032984, co-investigator, 07/01/2015- 06/30/2020 (7) NIA U01DK048404, co-investigator, 08/15/1994- 01/31/2021 (8) NIA U54AG052427, co-investigator, 04/15/2016- 02/28/2021 (9) NIA R01AG049810, co-investigator, 03/15/2016- 02/28/2021 (10) NIA RF1AG054070, co-PI, 07/01/2016-03/31/2021 (11) NIA RF1AG056164, PI, 09/15/2016-06/30/2021 (12) NIA RF1AG054023, co-investigator, 09/01/2016- 06/30/2021

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Nicole Schupf, PhD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1.NIH U01AG051412;PI, 09/30/2015-04/30/20 2.NIH R56AG034189; co-Invest 07/01/2009-08/31/2018 3.NIH R01AG049810; co-invest 03/15/2016-02/28/2021 4.NIH U01AG023749; co-invest 06/01/2004 - 05/31/2019 5.NIH 1RF1AG054070; co-invest 09/01/2016-06/30/2021 6. NIH RF1AG054023; co-invest 08/01/2016 - 06/30/2021 7. NIH P50AG008702; ADRC member,06/15/1997-05/31/2020 8. NIH R01AG043679; co-invest,09/01/2014-05/31/2020

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Alzheimer's Association: DSAD-15-364171: PI, 11/01/2015-10/31/2018

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Adam M. Brickman, PhD and
    8. Scientific Advisory Boards:

    1. Currently serve on the scientific advisory board of Keystone Heart. Serve on DSMB of a National Institutes of Aging supported study of a dietary intervention.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Editorial board member of The Journal of the International Neuropsychological Society. Editorial board member of Neuropsychology Review Associate editor of Neurodegenerative Diseases

    Patents:

    1. US patent 9,867,566, Technologies for white matter hyperintensity quantification.

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Consultant for ProPhase. Years: 2007-2011 and 2013-present. Consultant for Keystone Heart. Years: 2012-Present. Consultant for Cognition Therapeutics, Inc. Years 2018-present

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. grant support: NIH AG029949 PI 2007-2012 NIH AG024708 PI 2004-2006 NIH AG043337 PI 2012-2014 NIH AG034189 PI 2010- NIH AG008702 PI (project 1) 2015- NIH AG054070 MPI 2016- NIH AG051556 MPI 2016-

    Research Support, Academic Entities:

    1. grant support: Columbia University PI 2008-2009 Columbia University PI 2012-2013

    Research Support, Foundations and Societies:

    1. grant support: Alzheimer's Association PI 2005-2007 Alzheimer's Association PI 2010-2012 Mary E. Groff Surgical Medical Research and Education Charitable Trust PI 2012-2013

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Richard Mayeux, MD
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. RO1 AG041797 Epidemiology of Familial Late Onset Alzheimer's Disease. U24 AG056270 National Institute on Aging Late Onset of Alzheimer's Disease Family Based Study

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Taub Institute for Research in Alzheimer's Disease and the Aging Brain (Y.G., I.B.M., V.A.G., J.J.M., N.S., A.M.B., R.M.), Columbia University; Department of Neurology (Y.G., J.G., J.J.M., N.S., A.M.B., R.M.), Columbia University and the New York Presbyterian Hospital; Department of Epidemiology (Y.G., N.S., R.M.), Joseph P. Mailman School of Public Health, Columbia University; and the Gertrude H. Sergievsky Center (Y.G., J.J.M., A.M.B., R.M.), Columbia University, New York.
  1. Correspondence
    Dr. Gu yg2121{at}columbia.edu

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