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January 2019; 6 (1) EditorialOpen Access

Drugs, bugs, and MS

The interplay between disease-modifying therapy and gut microbiota

Ashutosh K. Mangalam
First published November 27, 2018, DOI: https://doi.org/10.1212/NXI.0000000000000524
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Article Information

vol. 6 no. 1 e524
DOI: 
https://doi.org/10.1212/NXI.0000000000000524
PubMed: 
30569001
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Online ISSN: 
2332-7812
History: 
  • First Published November 27, 2018.
Copyright & Usage: 
Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Author Disclosures

    1. Ashutosh K. Mangalam, PhD
  1. Ashutosh K. Mangalam, PhD
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. USA patent issued on 10/31/2017 as US Patent No. 9,801,914 titled "Prevotella histicola Preparations and the Treatment of Autoimmune Conditions"

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1. Linking diet, gut microbiota and autoimmune disease: Bacteria induced phytoestrogen metabolites impact immune function in Experimental Autoimmune Encephalitis (1R01AI137075-01) R01 02/15/2018-01/31/2023 NIH- The National Institute of Allergy and Infectious Diseases Role- Principal Investigator The goal of this project to determine the mechanisms through gut bacteria induced phytoestrogen metabolism regulate the host immune response during health and disease. 2. Effect of Exposure to the herbicide Glyphosate on the host gut microbiome and systemic inflammation in mice The Environmental Health Sciences Research Center Pilot grant University of Iowa Sep 1 | 2017 - Aug 31 | 2018 Role- Principal Investigator The goals of this pilot project is to generate preliminary data for a federal or foundation grant to test the hypothesis that glyphosate induced systemic inflammation play an important role in predisposition to inflammatory diseases and glyphosate induced changes in gut microbiota and their metabolites play a crucial role in this process 3. Longitudinal Analysis of Low pH Streptococci and Plaque Microbiome in Early Childhood Caries Research grant 06/01/2018-05/31/2023 NIH/NIDCR Role- Co-Investigator (PI- Banas and Drake) The objectives of this study are to determine the role of low pH streptococci other than, or in conjunction with, the mutans streptococci in the development of dental decay in young children.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1. Role of gut microbiome in age-associated thrombosis 2018 Innovative Project Award 07/01/2018 to 06/30/2020 American Heart Association (AHA) Role- Co-Investigator (PI- Dayal) The objectives of this study are to how aging-related changes in the gut microbiome affect thrombosis. This novel study will also examine how the antioxidant glutathione peroxidase 1 (Gpx1) alters the gut microbiome. 2. Therapeutic potential of combination therapy using Human Gut-derived commensal bacteria and conventional MS drugs RG 5138A1/1 Research grant 04/01/2015-03/31/2018 National Multiple Sclerosis Society (NMSS) Role PI The goal of this project is to evaluate efficacy of combination therapy (Prevotella histicola, Copaxone and interferon beta) in animal model of human MS.

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. Received royalties from Mayo Clinic, who has licensed the technology for the use of Prevotella histicola to Evelo Biosciences.

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA.
  1. Correspondence
    Dr. Mangalam Ashutosh-mangalam{at}uiowa.edu
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