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May 2019; 6 (3) Views & ReviewsOpen Access

Antineuroinflammatory drugs in HIV-associated neurocognitive disorders as potential therapy

Björn Ambrosius, Ralf Gold, Andrew Chan, Simon Faissner
First published April 4, 2019, DOI: https://doi.org/10.1212/NXI.0000000000000551
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Article Information

vol. 6 no. 3 e551
DOI: 
https://doi.org/10.1212/NXI.0000000000000551
PubMed: 
31119186
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Online ISSN: 
2332-7812
History: 
  • Received November 3, 2018
  • Accepted in final form February 17, 2019
  • First Published April 4, 2019.
Copyright & Usage: 
Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Author Disclosures

    1. Björn Ambrosius, PhD,
    2. Ralf Gold, MD,
    3. Andrew Chan, MD and
    4. Simon Faissner, MD
  1. Björn Ambrosius, PhD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Commercial, travel grant, 5000? Novartis for AAN 2016

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. Celgene GmbH, associate Regional Medical Liaison, since September 2018

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. FORUM Anschubfinanzierung, Medizinische Faktult?t Ruhr Universit?t Bochum, F?rderkennzeichen: F859-15

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Ralf Gold, MD,
    3. Scientific Advisory Boards:

    1. (1) TEVA Laquinimod DSMB

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Speaker honoraria from Biogen, Genzyme, TEVA, Merckserono, BayerSchering,Celgene, Novartis

    Editorial Boards:

    1. SAGE Journal, Aktuelle Neurologie, Experimental Neurology

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Andrew Chan, MD and
    4. Scientific Advisory Boards:

    1. (1) Almirall (2) Actelion (3) Bayer (4) Biogen (5) Celgene (6) Genzyme (7) Merck (8) Novartis (8) Roche (9) Teva

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (1) Almirall (2) Actelion (3) Bayer (4) Biogen (5) Celgene (6) Genzyme (7) Merck (8) Novartis (8) Roche (9) Teva; travel and speaker honoraria, all for University Research funds

    Editorial Boards:

    1. Clinical and Translational Neuroscience (Editorial board) Topic editor, Journal of International medical research

    Patents:

    1. (1) mTOR inhibition as mechanism to increase glucocorticosteroid efficacy

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Research support from Biogen, Genzyme, UCB

    Research Support, Government Entities:

    1. (1) Schweizer Nationalfonds, Principle investigator, 2 years

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Swiss multiple sclerosis society, Co-PI, 2 years

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Simon Faissner, MD
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (1) Speaker honoraria from Novartis, not related to the content of this manuscript.

    Editorial Boards:

    1. NONE

    Patents:

    1. (1) V. W. Yong, M. Koch, S. Faissner. United States Patent Application No. 62/412,534 filed October 25, 2016, relating to, and entitled: Treatment for Progressive Multiple Sclerosis. (2) V. W. Yong, M. Koch, L. Metz, M. Mishra, S. Faissner. United States Patent Application No. 62/412,555 filed October 25, 2016, relating to, and entitled: Combination therapy with minocycline and hydroxychloroquine for the treatment of multiple sclerosis (MS).

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. (1) Medical Faculty of Ruhr-University Bochum, FoRUM (F898- 17), not related to this manuscript.

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Department of Neurology (B.A., R.G., S.F.), St. Josef-Hospital, Ruhr-University Bochum, Gudrunstr, Bochum, Germany; and Department of Neurology (A.C.), University Hospital Bern, Bern University, Switzerland.
  1. Correspondence
    Dr. Ambrosius Bjoern.Ambrosius{at}ruhr-uni-bochum.de or Dr. Faissner Simon.Faissner{at}ruhr-uni-bochum.de
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