Gray matter microglial activation in relapsing vs progressive MS
A [F-18]PBR06-PET study
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Article Information
- Received November 19, 2018
- Accepted in final form May 15, 2019
- First Published July 1, 2019.
Author Disclosures
- Tarun Singhal, MD,
- Kelsey O'Connor, BS,
- Shipra Dubey, PhD,
- Hong Pan, PhD,
- Renxin Chu, PhD,
- Shelley Hurwitz, PhD,
- Steven Cicero, BS,
- Shahamat Tauhid, MD,
- David Silbersweig, MD,
- Emily Stern, MD,
- Marie Kijewski, DSc,
- Marcelo DiCarli, MD,
- Howard L. Weiner, MD and
- Rohit Bakshi, MD, MA
- Tarun Singhal, MD,
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National Multiple Sclerosis Society
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- Kelsey O'Connor, BS,
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- Shipra Dubey, PhD,
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- Hong Pan, PhD,
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(1) Systems and Methods For Generating Biomarkers Based On Multivariate Classification Of Functional Imaging and Associated Data. (2) System and Method For Z-Shim Compensated Echo-Planar Magnetic Resonance Imaging. (3) System and Method for a Multivariate, Automated, Systematic and Hierarchical Searching Algorithm for Biosignature Extraction and Biomarker Discovery via Task- based fMRI Imaging Spacetime Data.
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- Renxin Chu, PhD,
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- Shelley Hurwitz, PhD,
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(1) Foundation for Neurologic Diseases
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- Steven Cicero, BS,
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- Shahamat Tauhid, MD,
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Journal of Neuroimaging, Managing Editor, 2015-present
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- David Silbersweig, MD,
american foundation for suicide prevention (non-profit)
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speaker at American Neuropsychiatric Association annual meeting 2019
Consulting editor, Journal of Neuropsychiatry and Clinical Neurosciences Editorial Board, Harvard Review of Psychiatry
(1) System and Method for z-Shim Compensated Echo- Planar Magnetic Resonance Imaging, and Systems (issued) (2) System and Methods for Generating Biomarkers Based on Multivariate Classification of Functional Imaging and Associated Data (issued) (3) System and Method for a Multivariate, Automated, Systematic and/or Hierarchical Searching System for Biosignature Extraction and Biomarker Discovery via task- based fMRI Imaging spacetime data (pending) (4) PhyNFI: System and Method for Physiological-Noise- Free Functional Magnetic Resonance Imaging (planned)
Depression in Medical Illness textbook, McGraw-Hill, 2017
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Biogen Sanofi Philips Goldfinch Tilak
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founder of a start-up company, not yet with any assets, not related to paper
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wife: contract with blackthorn therapeutics, not related to topic
wife:(1) DHSS Administration for Community Living, formerly the National Institute on Disability and Rehabilitation Research (NIDRR ? 90DP0039-03-01) Co-PI; PI, BWH Site, (10/1/12- 9/30/18) (2) NIH (NIMH ? R01MH090291) Co-investigator, (7/1/17 ? 6/30/22)
wife: Baylor college of medicine
wife: epilepsy foundation
founders shares in Compass Neurosciences, no current assets, unrelated founders shares in Buoyant, no current assets, unrelated
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- Emily Stern, MD,
(1) Spaulding Rehabilitation Hospital- TBI Model Systems SAB (non-profit) Husband:(2) American Foundation for suicide prevention (non- profit)
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(1) National Institute of Heath. Funding for travel for grant review (2) James S. McDonnell Foundation. Funding for travel to speak at conference Husband: (3) Speaker at American Neuropsychiatric Association 2019 Annual Meeting
(1)The International Journal of Imaging Systems and Technology ? Neuroimaging and Brain Mapping, Co-Editor (2011-2017) (2)Journal of Neuroimaging, Editorial Board. (2015-present) Husband: (3) Consulting editor, Journal of Neuropsychiatry and Clinical Neurosciences Editorial Board, Harvard Review of Psychiatry
(1)System and Method for z-Shim Compensated Echo-Planar Magnetic Resonance Imaging, and Systems (issued) (2)System and Methods for Generating Biomarkers Based on Multivariate Classification of Functional Imaging and Associated Data (issued) (3)System and Method for a Multivariate, Automated, Systematic and/or Hierarchical Searching System for Biosignature Extraction and Biomarker Discovery via task- based fMRI Imaging spacetime data (pending) (4)PhyNFI: System and Method for Physiological-Noise-Free Functional Magnetic Resonance Imaging (planned) [All of the above (1-4) apply to both Dr. Stern and her husband]
Husband only: (1) Depression in Medical Illness textbook, McGraw Hill 2017
(1)Brigham and Women?s Hospital, Director Functional Neuroimaging Laboratory, (2008-present) Husband: (2)Brigham and Women?s Hospital, Chairman Department of Psychiatry, (2008-present)
Husband only: (1) Philips (2) Sanofi (3) Biogen (4) Tilak (5) Goldfinch
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(1) Dr. Stern is the CEO of a startup company, Compass Neurosciences, that will be spinning out of Brigham and Women?s Hospital in the near future. This has not yet occurred, the company presently has no assets, and this activity did not influence what was written in this manuscript; however, it is felt that this is important to disclose. Husband: Co-founder of a company, Compass Neurosciences, the company presently has no assets, and this activity did not influence what was written in this manuscript
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(1) Blackthorn Therapeutics
(1) DHSS Administration for Community Living, formerly the National Institute on Disability and Rehabilitation Research (NIDRR ? 90DP0039-03-01) Co-PI; PI, BWH Site, (10/1/12- 9/30/18) (2) NIH (NIMH ? R01MH090291) Co-investigator, (7/1/17 ? 6/30/22)
(1) Baylor College of Medicine
(1)Epilepsy Foundation
(1) Compass NeuroSciences, Inc. Husband: (2)Founders shares for Compass NeuroSciences, Inc., no current assets, unrelated Husband: (3)Founders shares in Buoyant Health, no current assets, unrelated
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- Marie Kijewski, DSc,
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1. NIH, 5R01HL130563, co-investigator, 2017-2019 2. NIH, 5R01HL132021, co-investigator, 2017-2019 3. NIH, 5R01HL131910, co-investigator, 2017-2019
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- Marcelo DiCarli, MD,
(1) Sanofi Aventis, GE Healthcare
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Associate Editor, Journal of Nuclear Cardiology
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Gilead Sciences Spectrum Dynamics
NHLBI 5R01HL132021-03, 5T32HL094301-09
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- Howard L. Weiner, MD and
served on the advisory board for The Guthy Jackson Charitable Foundation, Teva Pharmaceutical Industries Ltd., Biogen Idec, Novartis, Sanofi-aventis, Tilos Therapeutics, CBridge Capital, Genentech, Genzyme, vTv Therapeutics, MedDay Pharmaceuticals
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Biodextris Biogen Novartis Serono Teva Sanofi Genzyme Tilos Therapeutics Tiziana Life Sciences vTv Therapeutics MedDay Pharmaceuticals Genentech CBridge Capital
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EMD Serono Google Life Sciences Verily Life Sciences
NIH UH3TR000890 - PI - 08/01/13 ? 07/31/18 R01 NS087226 - PI - 09/30/14 ? 07/31/19 R01 EY027921 - PI - 09/01/17 ? 08/31/20
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National Multiple Sclerosis Society
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- Rohit Bakshi, MD, MA
Dr. Bakshi has served on advisory boards for (1) Bayer, (2) Biogen, (3) Celgene, (4) EMD Serono, (5) Genentech, (6) Guerbet, (7) Sanofi-Genzyme, and (8) Shire.
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Dr. Bakshi received a speaking fee from (1) Novartis.
Dr. Bakshi serves as Editor-in-Chief of (1) the Journal of Neuroimaging
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Dr. Bakshi has received consulting fees from (1) EMD Serono.
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Dr. Bakshi has received research support from (1) EMD Serono, (2) Sanofi-Genzyme, and (3) Verily Life Sciences.
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Dr. Bakshi has received research support from the (1) Department of Defense (MS170140), (2) National Multiple Sclerosis Society (RR 2005-A-13 and RG-1707-28586), (3) Watercove foundation, and (4) Race to Erase MS. Stock/Stock Options, Medical Equipment & Materials: Dr. Bakshi's spouse holds stock in (1) Biogen, Inc. 2012-present.
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- From the Partners MS Center (T.S., K.O.C., R.C., S.C., S.T., H.L.W., R.B.), Laboratory for Neuroimaging Research, Ann Romney Center for Neurological Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School; Division of Nuclear Medicine and Molecular Imaging (S.D., M.K., M.D.), Department of Radiology, Brigham and Women's Hospital, Harvard Medical School; Functional Neuroimaging Laboratory (H.P., D.S., E.S.), Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School; Department of Medicine (S.H.) and Department of Radiology (E.S., R.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
- Correspondence
Dr. Singhal tsinghal{at}bwh.harvard.edu
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