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September 2019; 6 (5) ArticleOpen Access

Novel clinical features of glycine receptor antibody syndrome

A series of 17 cases

Amanda L. Piquet, Murtaza Khan, Judith E.A. Warner, Matthew P. Wicklund, Jeffrey L. Bennett, Maureen A. Leehey, Lauren Seeberger, Teri L. Schreiner, M. Mateo Paz Soldan, Stacey L. Clardy
First published July 1, 2019, DOI: https://doi.org/10.1212/NXI.0000000000000592
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Article Information

vol. 6 no. 5 e592
DOI: 
https://doi.org/10.1212/NXI.0000000000000592
PubMed: 
31454769
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Online ISSN: 
2332-7812
History: 
  • Received February 25, 2019
  • Accepted in final form May 16, 2019
  • First Published July 1, 2019.
Copyright & Usage: 
Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Author Disclosures

    1. Amanda L. Piquet, MD,
    2. Murtaza Khan, MD,
    3. Judith E.A. Warner, MD,
    4. Matthew P. Wicklund, MD,
    5. Jeffrey L. Bennett, MD, PhD,
    6. Maureen A. Leehey, MD,
    7. Lauren Seeberger, MD,
    8. Teri L. Schreiner, MD, MPH,
    9. M. Mateo Paz Soldan, MD, PhD and
    10. Stacey L. Clardy, MD, PhD
  1. Amanda L. Piquet, MD,
    2. Scientific Advisory Boards:

    1. (1) Sanofi Genzyme, consultant on scientific advisory board

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. (1) Honoraria from MedLink

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) Donation from the Drank family through the Children's Hospital of Colorado Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Murtaza Khan, MD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Judith E.A. Warner, MD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Matthew P. Wicklund, MD,
    5. Scientific Advisory Boards:

    1. 1. Myonexus Therapeutics 2. Sarepta Therapeutics

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Muscle & Nerve, Editorial board member, 2016 to present

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. 1. Acceleron 2. Orphazyme Stock/Stock Options, Medical Equipment & Materials: 1. Myonexus Therapeutics

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Jeffrey L. Bennett, MD, PhD,
    6. Scientific Advisory Boards:

    1. Clene Neuroscience

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Editorial Board, Journal of Neuro-ophthalmology Editorial Board, Multiple Sclerosis Journal Editorial Board, Neurology: Neuroimmunology & Neuroinflammation

    Patents:

    1. (1) Compositions and Methods for the Treatment of Neuromyelitis Optica; novel blocking monoclonal therapy for neuromyelitis optica: PCT/US2012/034662

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) EMD-Serono (2) Viela Bio (3) Clene Nanomedicine (4) Chugai Pharma USA (5) Genzyme (6) Frequency Therapeutics (7) Alexion Pharmaceuticals (8) Genentech

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Mallinckrodt Pharmaceuticals

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) National Institutes of Health (NEI) (2) Guthy-Jackson Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. (1) Aquaporumab, rights for future royalty payments

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Maureen A. Leehey, MD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (1) Parkinson Study Group, travel funding

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) GLG, (2) Guidepoint Global, (3) Synapsus, (4) Expert Connect, (5) Schlesinger, (6) Palladian, (7) Connected Research & Consulting, (8) Trinity Partners, (9) Toronto Western Hospital, (10) Leerink, (11) Design Science Consulting, (12) Harper Global, (13) Gerson Lehman, (14) Medacorp, (15) Parkinson Study Group

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Adamas Pharmaceuticals, (2) US WorldMeds LLC, (3) Biogen, (4) Neuroderm, (5)

    Research Support, Government Entities:

    1. (1) The National Institute of Neurological Disorders and Stroke, (2) Colorado Department of Public Health and Environment,

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Lauren Seeberger, MD,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. APDM Wearable Technologies-gifted wearable device for pilot Huntington disease study

    Funding for travel or speaker honoraria:

    1. 1)Huntington Study Group- travel, for education chair position to annual meeting 2)Friedreich's Ataxia Research Alliance-travel, for training to be a site for natural history study

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. 1) Reata Pharmaceuticals

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. 1)Vaccinex Pharmaceuticals/Huntington Study Group 2)Biohaven Pharmaceuticals 3)Parkinson Study Group/Michael J. Fox Foundation 4)Intec Pharma

    Research Support, Government Entities:

    1. 1) NeuroNext 105 NIH 2) ReadiSCA U01 NIH

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1)Huntington Study Group-travel and hotel, annual meeting 2)Parkinson Study Group-hotel, annual meeting

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Teri L. Schreiner, MD, MPH,
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Multiple Sclerosis Association of America, speaker honoraria Genentech, Speaker honoraria

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. ACI Clinical. I serve on the adjudication board for a randomized controlled trial of teriflunomide in pediatric MS patients.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. National MS Society. I have received research funding for participation in the US Network of Pediatric MS Centers.

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. M. Mateo Paz Soldan, MD, PhD and
    10. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Biogen

    Research Support, Government Entities:

    1. (1) National Institutes of Health

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) National Multiple Sclerosis Society, (2) Western Institute for Biomedical Research

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. Stacey L. Clardy, MD, PhD
    11. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Section Editor, Neurology Podcast (July 2018-present) and Neurology Minute (March 2019-present)

    Patents:

    1. NONE

    Publishing Royalties:

    1. One time honorarium related to Guest Editor of the Autoimmune Neurology issue of Seminars in neurology.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. 2-3 consulting phone calls per year, 1 hour maximum, by related to this paper, each $500 US or less. Proceeds support University Development activities and Dr. Clardy does not receive direct payment.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. Research support from Western Institute for Biomedical Research (WIBR).

    Research Support, Foundations and Societies:

    1. Transverse Myelitis Association and ARIA foundation.

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Department of Neurology (A.L.P., M.K., M.P.W., J.L.B., M.A.L., L.S., T.L.S.), University of Colorado, Aurora; Department of Neurology (A.L.P., J.E.A.W., M.M.P.S., S.L.C.), University of Utah; Department of Ophthalmology (J.E.A.W.), Moran Eye Center, University of Utah, Salt Lake City; Department of Ophthalmology and Program in Neuroscience (J.L.B.), University of Colorado; Department of Neurology (T.L.S.), Children's Hospital Colorado, Aurora; and Department of Veterans Affairs (M.M.P.S., S.L.C.), George E. Wahlen Veterans Affairs Medical Center, Salt Lake City, UT.
  1. Correspondence
    Dr. Piquet Amanda.Piquet{at}ucdenver.edu
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