Share

September 2019; 6 (5) ArticleOpen Access

Lesion activity and chronic demyelination are the major determinants of brain atrophy in MS

Chenyu Wang, Michael H. Barnett, Con Yiannikas, Joshua Barton, John Parratt, Yuyi You, Stuart L. Graham, Alexander Klistorner
First published July 16, 2019, DOI: https://doi.org/10.1212/NXI.0000000000000593
Full PDF
Citation
Permissions

Make Comment

See Comments

Downloads
880

Share

Article Figures & Data

Figures

  • Figure 1
    Figure 1 Segmentation of lesional, perilesional, and normal-appearing white matter displayed on baseline T1 image

    Red represents lesion core, green represents lesion “rim,” perilesional white matter (PLWM) layers (layer 1 and layer 5) are yellow and magenta, and NAWM layer (layer 10) is blue. Layer number represents distance from the lesion in mm.

  • Figure 2
    Figure 2 The average T1 hypointensity profile (mean ± SD) normalized by T1 intensity in NAWM
  • Figure 3
    Figure 3 Correlation plots between PBVC and 5 individually significant variables

    (A) Baseline lesion volume (vertical scale units, mm3); (B) new lesion volume (vertical scale units, mm3); (C) baseline NAWM RD (vertical scale units, μm2/ms); (D) change in lesion MD (vertical scale units, μm2/ms); and (E) change in NAWM RD (vertical scale units, μm2/ms). Two parallel lines represent 95% CI. PBVC = percent brain volume change.

  • Figure 4
    Figure 4 Change of AD and RD in lesion core, lesion “rim,” perilesional, and normal-appearing white matter

    Error bars represent SE. AD = axial diffusivity; RD = radial diffusivity.

  • Figure 5
    Figure 5 PBVC linear regression analysis

    Two parallel lines represent 95% CI. PBVC = percent brain volume change.

Tables

  • Table 1
  • Table 2
  • Table3

Letters: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
Advertisement

Related Articles

  • No related articles found.

Topics Discussed

Alert Me

Recommended articles