Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Specialty Sites
    • COVID-19
    • Without Borders
    • Equity, Diversity, and Inclusion
    • Innovations in Care Delivery
    • Practice Current
  • Collections
    • Topics A-Z
    • Residents & Fellows
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Specialty Sites
    • COVID-19
    • Without Borders
    • Equity, Diversity, and Inclusion
    • Innovations in Care Delivery
    • Practice Current
  • Collections
    • Topics A-Z
    • Residents & Fellows
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center
  • Home
  • Articles
  • Issues

User menu

  • My Alerts
  • Log in

Search

  • Advanced search
Neurology Neuroimmunology & Neuroinflammation
Home
A peer-reviewed clinical and translational neurology open access journal
  • My Alerts
  • Log in
Site Logo
  • Home
  • Articles
  • Issues

Share

September 2019; 6 (5) ArticleOpen Access

Relationship between retinal inner nuclear layer, age, and disease activity in progressive MS

Maria Cellerino, Christian Cordano, Giacomo Boffa, Giulia Bommarito, Maria Petracca, Elvira Sbragia, Giovanni Novi, Caterina Lapucci, Elisabetta Capello, Antonio Uccelli, Matilde Inglese
First published August 12, 2019, DOI: https://doi.org/10.1212/NXI.0000000000000596
Maria Cellerino
From the Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI) (M.C., C.C., G. Boffa, G. Bommarito, E.S., G.N., C.L., A.U., M.I.), University of Genoa, Italy; Department of Neurology (C.C.), Multiple Sclerosis Center, University of California, San Francisco; Departments of Neurology, Radiology and Neuroscience (M.P., M.I.), Icahn School of Medicine at Mount Sinai, New York; and Ospedale Policlinico San Martino-IRCCS (E.C., A.U., M.I.), Genoa, Italy.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christian Cordano
From the Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI) (M.C., C.C., G. Boffa, G. Bommarito, E.S., G.N., C.L., A.U., M.I.), University of Genoa, Italy; Department of Neurology (C.C.), Multiple Sclerosis Center, University of California, San Francisco; Departments of Neurology, Radiology and Neuroscience (M.P., M.I.), Icahn School of Medicine at Mount Sinai, New York; and Ospedale Policlinico San Martino-IRCCS (E.C., A.U., M.I.), Genoa, Italy.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Giacomo Boffa
From the Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI) (M.C., C.C., G. Boffa, G. Bommarito, E.S., G.N., C.L., A.U., M.I.), University of Genoa, Italy; Department of Neurology (C.C.), Multiple Sclerosis Center, University of California, San Francisco; Departments of Neurology, Radiology and Neuroscience (M.P., M.I.), Icahn School of Medicine at Mount Sinai, New York; and Ospedale Policlinico San Martino-IRCCS (E.C., A.U., M.I.), Genoa, Italy.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Giulia Bommarito
From the Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI) (M.C., C.C., G. Boffa, G. Bommarito, E.S., G.N., C.L., A.U., M.I.), University of Genoa, Italy; Department of Neurology (C.C.), Multiple Sclerosis Center, University of California, San Francisco; Departments of Neurology, Radiology and Neuroscience (M.P., M.I.), Icahn School of Medicine at Mount Sinai, New York; and Ospedale Policlinico San Martino-IRCCS (E.C., A.U., M.I.), Genoa, Italy.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maria Petracca
From the Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI) (M.C., C.C., G. Boffa, G. Bommarito, E.S., G.N., C.L., A.U., M.I.), University of Genoa, Italy; Department of Neurology (C.C.), Multiple Sclerosis Center, University of California, San Francisco; Departments of Neurology, Radiology and Neuroscience (M.P., M.I.), Icahn School of Medicine at Mount Sinai, New York; and Ospedale Policlinico San Martino-IRCCS (E.C., A.U., M.I.), Genoa, Italy.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elvira Sbragia
From the Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI) (M.C., C.C., G. Boffa, G. Bommarito, E.S., G.N., C.L., A.U., M.I.), University of Genoa, Italy; Department of Neurology (C.C.), Multiple Sclerosis Center, University of California, San Francisco; Departments of Neurology, Radiology and Neuroscience (M.P., M.I.), Icahn School of Medicine at Mount Sinai, New York; and Ospedale Policlinico San Martino-IRCCS (E.C., A.U., M.I.), Genoa, Italy.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Giovanni Novi
From the Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI) (M.C., C.C., G. Boffa, G. Bommarito, E.S., G.N., C.L., A.U., M.I.), University of Genoa, Italy; Department of Neurology (C.C.), Multiple Sclerosis Center, University of California, San Francisco; Departments of Neurology, Radiology and Neuroscience (M.P., M.I.), Icahn School of Medicine at Mount Sinai, New York; and Ospedale Policlinico San Martino-IRCCS (E.C., A.U., M.I.), Genoa, Italy.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Caterina Lapucci
From the Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI) (M.C., C.C., G. Boffa, G. Bommarito, E.S., G.N., C.L., A.U., M.I.), University of Genoa, Italy; Department of Neurology (C.C.), Multiple Sclerosis Center, University of California, San Francisco; Departments of Neurology, Radiology and Neuroscience (M.P., M.I.), Icahn School of Medicine at Mount Sinai, New York; and Ospedale Policlinico San Martino-IRCCS (E.C., A.U., M.I.), Genoa, Italy.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elisabetta Capello
From the Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI) (M.C., C.C., G. Boffa, G. Bommarito, E.S., G.N., C.L., A.U., M.I.), University of Genoa, Italy; Department of Neurology (C.C.), Multiple Sclerosis Center, University of California, San Francisco; Departments of Neurology, Radiology and Neuroscience (M.P., M.I.), Icahn School of Medicine at Mount Sinai, New York; and Ospedale Policlinico San Martino-IRCCS (E.C., A.U., M.I.), Genoa, Italy.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Antonio Uccelli
From the Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI) (M.C., C.C., G. Boffa, G. Bommarito, E.S., G.N., C.L., A.U., M.I.), University of Genoa, Italy; Department of Neurology (C.C.), Multiple Sclerosis Center, University of California, San Francisco; Departments of Neurology, Radiology and Neuroscience (M.P., M.I.), Icahn School of Medicine at Mount Sinai, New York; and Ospedale Policlinico San Martino-IRCCS (E.C., A.U., M.I.), Genoa, Italy.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Matilde Inglese
From the Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI) (M.C., C.C., G. Boffa, G. Bommarito, E.S., G.N., C.L., A.U., M.I.), University of Genoa, Italy; Department of Neurology (C.C.), Multiple Sclerosis Center, University of California, San Francisco; Departments of Neurology, Radiology and Neuroscience (M.P., M.I.), Icahn School of Medicine at Mount Sinai, New York; and Ospedale Policlinico San Martino-IRCCS (E.C., A.U., M.I.), Genoa, Italy.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Citation
Relationship between retinal inner nuclear layer, age, and disease activity in progressive MS
Maria Cellerino, Christian Cordano, Giacomo Boffa, Giulia Bommarito, Maria Petracca, Elvira Sbragia, Giovanni Novi, Caterina Lapucci, Elisabetta Capello, Antonio Uccelli, Matilde Inglese
Neurol Neuroimmunol Neuroinflamm Sep 2019, 6 (5) e596; DOI: 10.1212/NXI.0000000000000596

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
360

Share

  • Article
  • Figures & Data
  • Info & Disclosures
Loading

Abstract

Objective To investigate whether inner nuclear layer (INL) thickness as assessed with optical coherence tomography differs between patients with progressive MS (P-MS) according to age and disease activity.

Methods In this retrospective longitudinal analysis, differences in terms of peripapillary retinal nerve fiber layer (pRNFL), ganglion cell layer + inner plexiform layer (GCIPL), INL and T1/T2 lesion volumes (T1LV/T2LV) were assessed between 84 patients with P-MS and 36 sex- and age-matched healthy controls (HCs) and between patients stratified according to age (cut-off: 51 years) and evidence of clinical/MRI activity in the previous 12 months

Results pRNFL and GCIPL thickness were significantly lower in patients with P-MS than in HCs (p = 0.003 and p < 0.0001, respectively). INL was significantly thicker in patients aged < 51 years compared to the older ones and HCs (38.2 vs 36.5 and 36.7 μm; p = 0.038 and p = 0.04, respectively) and in those who presented MRI activity (new T2/gadolinium-enhancing lesions) in the previous 12 months compared to the ones who did not and HCs (39.5 vs 36.4 and 36.7 μm; p = 0.003 and p = 0.008, respectively). Recent MRI activity was significantly predicted by greater INL thickness (Nagelkerke R2 0.36, p = 0.001).

Conclusions INL thickness was higher in younger patients with P-MS with recent MRI activity, a criterion used in previous studies to identify a specific subset of patients with P-MS who best responded to disease-modifying treatment. If this finding is confirmed, we suggest that INL thickness might be a useful tool in stratification of patients with P-MS for current and experimental treatment choice.

Glossary

DMT=
disease-modifying treatment;
EDSS=
Expanded Disability Status Scale;
GCIPL=
ganglion cell layer + inner plexiform layer;
HC=
healthy control;
INL=
inner nuclear layer;
LV=
lesion volume;
MME=
microcystic macular edema;
OCT=
optical coherence tomography;
ON=
optic neuritis;
P-MS=
progressive MS;
pRNFL=
peripapillary retinal nerve fiber layer;
RR=
relapsing-remitting

Footnotes

  • Go to Neurology.org/NN for full disclosures. Funding information is provided at the end of the article.

  • The Article Processing Charge was funded by the authors.

  • Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

View Full Text

Letters: Rapid online correspondence

No comments have been published for this article.
Comment

NOTE: All contributors' disclosures must be entered and current in our database before comments can be posted. Enter and update disclosures at http://submit.nn.neurology.org. Exception: replies to comments concerning an article you originally authored do not require updated disclosures.

  • Stay timely. Submit only on articles published within the last 8 weeks.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • 200 words maximum.
  • 5 references maximum. Reference 1 must be the article on which you are commenting.
  • 5 authors maximum. Exception: replies can include all original authors of the article.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Letters

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Letters Submission Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Abstract
    • Glossary
    • Methods
    • Results
    • Discussion
    • Conclusions
    • Study funding
    • Disclosure
    • Appendix Authors
    • Footnotes
    • References
  • Figures & Data
  • Info & Disclosures

Related Articles

  • No related articles found.

Topics Discussed

  • Multiple sclerosis
  • Optic nerve
  • Retina

Alert Me

  • Alert me when eletters are published
Advertisement
Neurology - Neuroimmunology Neuroinflammation: 8 (3)

Articles

  • Articles
  • Issues
  • Popular Articles

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology: Neuroimmunology & Neuroinflammation
Online ISSN: 2332-7812

© 2021 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise