Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Specialty Sites
    • COVID-19
    • Without Borders
    • Equity, Diversity, and Inclusion
    • Innovations in Care Delivery
    • Practice Current
  • Collections
    • Topics A-Z
    • Residents & Fellows
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Specialty Sites
    • COVID-19
    • Without Borders
    • Equity, Diversity, and Inclusion
    • Innovations in Care Delivery
    • Practice Current
  • Collections
    • Topics A-Z
    • Residents & Fellows
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center
  • Home
  • Articles
  • Issues

User menu

  • My Alerts
  • Log in

Search

  • Advanced search
Neurology Neuroimmunology & Neuroinflammation
Home
A peer-reviewed clinical and translational neurology open access journal
  • My Alerts
  • Log in
Site Logo
  • Home
  • Articles
  • Issues

Share

September 2019; 6 (5) ArticleOpen Access

High serum neurofilament light chain normalizes after hematopoietic stem cell transplantation for MS

Simon Thebault, Daniel R. Tessier, Hyunwoo Lee, Marjorie Bowman, Amit Bar-Or, Douglas L. Arnold, Harold L. Atkins, Vincent Tabard-Cossa, Mark S. Freedman
First published August 9, 2019, DOI: https://doi.org/10.1212/NXI.0000000000000598
Simon Thebault
From the The University of Ottawa and Ottawa Hospital Research Institute (S.T., M.B., H.L.A., M.S.F.); Department of Physics (D.R.T., V.T.-C.), University of Ottawa; Montreal Neurological Institute (H.L., D.L.A.); and Perelman School of Medicine and University of Pennsylvania (A.B.-O.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daniel R. Tessier
From the The University of Ottawa and Ottawa Hospital Research Institute (S.T., M.B., H.L.A., M.S.F.); Department of Physics (D.R.T., V.T.-C.), University of Ottawa; Montreal Neurological Institute (H.L., D.L.A.); and Perelman School of Medicine and University of Pennsylvania (A.B.-O.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hyunwoo Lee
From the The University of Ottawa and Ottawa Hospital Research Institute (S.T., M.B., H.L.A., M.S.F.); Department of Physics (D.R.T., V.T.-C.), University of Ottawa; Montreal Neurological Institute (H.L., D.L.A.); and Perelman School of Medicine and University of Pennsylvania (A.B.-O.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marjorie Bowman
From the The University of Ottawa and Ottawa Hospital Research Institute (S.T., M.B., H.L.A., M.S.F.); Department of Physics (D.R.T., V.T.-C.), University of Ottawa; Montreal Neurological Institute (H.L., D.L.A.); and Perelman School of Medicine and University of Pennsylvania (A.B.-O.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Amit Bar-Or
From the The University of Ottawa and Ottawa Hospital Research Institute (S.T., M.B., H.L.A., M.S.F.); Department of Physics (D.R.T., V.T.-C.), University of Ottawa; Montreal Neurological Institute (H.L., D.L.A.); and Perelman School of Medicine and University of Pennsylvania (A.B.-O.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Douglas L. Arnold
From the The University of Ottawa and Ottawa Hospital Research Institute (S.T., M.B., H.L.A., M.S.F.); Department of Physics (D.R.T., V.T.-C.), University of Ottawa; Montreal Neurological Institute (H.L., D.L.A.); and Perelman School of Medicine and University of Pennsylvania (A.B.-O.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Harold L. Atkins
From the The University of Ottawa and Ottawa Hospital Research Institute (S.T., M.B., H.L.A., M.S.F.); Department of Physics (D.R.T., V.T.-C.), University of Ottawa; Montreal Neurological Institute (H.L., D.L.A.); and Perelman School of Medicine and University of Pennsylvania (A.B.-O.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vincent Tabard-Cossa
From the The University of Ottawa and Ottawa Hospital Research Institute (S.T., M.B., H.L.A., M.S.F.); Department of Physics (D.R.T., V.T.-C.), University of Ottawa; Montreal Neurological Institute (H.L., D.L.A.); and Perelman School of Medicine and University of Pennsylvania (A.B.-O.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mark S. Freedman
From the The University of Ottawa and Ottawa Hospital Research Institute (S.T., M.B., H.L.A., M.S.F.); Department of Physics (D.R.T., V.T.-C.), University of Ottawa; Montreal Neurological Institute (H.L., D.L.A.); and Perelman School of Medicine and University of Pennsylvania (A.B.-O.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Citation
High serum neurofilament light chain normalizes after hematopoietic stem cell transplantation for MS
Simon Thebault, Daniel R. Tessier, Hyunwoo Lee, Marjorie Bowman, Amit Bar-Or, Douglas L. Arnold, Harold L. Atkins, Vincent Tabard-Cossa, Mark S. Freedman
Neurol Neuroimmunol Neuroinflamm Sep 2019, 6 (5) e598; DOI: 10.1212/NXI.0000000000000598

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
598

Share

  • Article
  • Figures & Data
  • Info & Disclosures
Loading

Abstract

Objective To evaluate neurofilament light chain (NfL) levels in serum and CSF of patients with aggressive MS pre- and post-treatment with immunoablation followed by autologous hematopoietic stem cell transplantation (IAHSCT) and examine associations with clinical and MRI outcomes.

Methods Paired serum and CSF in addition to MRI and clinical measures were collected on 23 patients with MS at baseline and 1 and 3 years post-IAHSCT. An additional 33 sera and CSF pairs were taken from noninflammatory neurologic controls. NfL levels were quantitated using the Simoa platform (Quanterix).

Results Baseline MS NfL levels were significantly elevated relative to controls in serum (p = 0.001) and CSF (p = 0.001). Following IAHSCT, high pretreatment NfL levels significantly reduced in serum (p = 0.0023) and CSF (p = 0.0068) and were not significantly different from controls. Serum and CSF NfL levels highly correlated (r = 0.81, p < 0.0001). Baseline NfL levels were associated with worse pretreatment disease measures (Expanded Disability Status Scale [EDSS], relapses, MRI lesions, and MR spectroscopy (MRS) N-acetylaspartate/creatine). Elevated baseline NfL levels were associated with persistently worse indices of disease burden post-IAHSCT (sustained EDSS progression, cognition, quality of life, T1 and T2 lesion volumes, MRS, and brain atrophy).

Conclusion These data substantiate that serum and CSF NfL levels reflect disease severity and treatment response in patients with MS and may therefore be a useful biomarker. Baseline serum levels associated with markers of pretreatment disease severity and post-treatment outcomes.

Classification of evidence This study provides Class II evidence that for patients with aggressive MS, serum NfL levels are associated with disease severity.

Glossary

DMT=
disease-modifying treatment;
EDSS=
Expanded Disability Status Scale;
FIS=
Fatigue Impact Score;
IAHSCT=
immunoablation followed by autologous hematopoietic stem cell transplantation;
MRS=
MR spectroscopy;
MSQOL=
MS Quality of Life;
NAA/Cr=
N-acetylaspartate/creatine;
NfL=
neurofilament light chain;
RRMS=
relapsing-remitting MS;
SPMS=
secondary progressive MS;
VOI=
volume of interest

Footnotes

  • Go to Neurology.org/NN for full disclosures. Funding information is provided at the end of the article.

  • The Article Processing Charge was funded by the authors.

  • Editorial, page e599

  • Received January 11, 2019.
  • Accepted in final form April 29, 2019.
  • Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

View Full Text

Letters: Rapid online correspondence

No comments have been published for this article.
Comment

NOTE: All contributors' disclosures must be entered and current in our database before comments can be posted. Enter and update disclosures at http://submit.nn.neurology.org. Exception: replies to comments concerning an article you originally authored do not require updated disclosures.

  • Stay timely. Submit only on articles published within the last 8 weeks.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • 200 words maximum.
  • 5 references maximum. Reference 1 must be the article on which you are commenting.
  • 5 authors maximum. Exception: replies can include all original authors of the article.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Letters

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Letters Submission Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Abstract
    • Glossary
    • Methods
    • Results
    • Discussion
    • Study funding
    • Disclosure
    • Acknowledgment
    • Appendix Authors
    • Footnotes
    • References
  • Figures & Data
  • Info & Disclosures

Related Articles

  • Blood neurofilament light chain at the doorstep of clinical application

Topics Discussed

  • Class II
  • Multiple sclerosis
  • Clinical trials Methodology/study design
  • Clinical trials Observational study (Cohort, Case control)

Alert Me

  • Alert me when eletters are published
Advertisement
Neurology - Neuroimmunology Neuroinflammation: 8 (3)

Articles

  • Articles
  • Issues
  • Popular Articles

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology: Neuroimmunology & Neuroinflammation
Online ISSN: 2332-7812

© 2021 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise