Article Figures & Data
Figures
- Figure Modeling of the interaction between Class II molecules and IgLON5 peptides
Detail of the pockets P7 and P9 in the modeled complexes between peptides LRLLAAAAL (A) and IVHVPARIV (B) of IgLON5 and molecules HLA-DRB1*01:01 and HLA-DRB1*10:01. Residues 7–9 (from right to left) of the peptides are represented as sticks, with the carbons in golden yellow. Protein residues forming the pockets are represented as sticks, with carbon atoms in teal blue. Covering the protein atoms, their Connolly surface is represented to facilitate the visualization of the pockets. Noncarbon atoms are colored as follows: N-blue, H-light gray, O-red, and S-yellow. It can be observed that P9 (cavity at the left of each panel) is shallower in HLA-DRB1*10:01 than in HLA-DRB1*01:01. As a result, the aliphatic residues at position 9 of both peptides bind more deeply in HLA-DRB1*01:01. The models also show that the Arg (R) residue at position 7 in IVHVPARIV is too bulky for the small P7 and has to orient its side chain toward previous pockets, particularly in HLA-DRB1*10:01.
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