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November 2019; 6 (6) ArticleOpen Access

Contribution of normal aging to brain atrophy in MS

Christina J. Azevedo, Steven Y. Cen, Amir Jaberzadeh, Ling Zheng, Stephen L. Hauser, Daniel Pelletier
First published September 25, 2019, DOI: https://doi.org/10.1212/NXI.0000000000000616
Christina J. Azevedo
From the Department of Neurology (C.J.A., S.Y.C., A.J., L.Z., D.P.), University of Southern California, Los Angeles; and Department of Neurology (S.L.H.), University of California, San Francisco.
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Steven Y. Cen
From the Department of Neurology (C.J.A., S.Y.C., A.J., L.Z., D.P.), University of Southern California, Los Angeles; and Department of Neurology (S.L.H.), University of California, San Francisco.
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Amir Jaberzadeh
From the Department of Neurology (C.J.A., S.Y.C., A.J., L.Z., D.P.), University of Southern California, Los Angeles; and Department of Neurology (S.L.H.), University of California, San Francisco.
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Ling Zheng
From the Department of Neurology (C.J.A., S.Y.C., A.J., L.Z., D.P.), University of Southern California, Los Angeles; and Department of Neurology (S.L.H.), University of California, San Francisco.
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Stephen L. Hauser
From the Department of Neurology (C.J.A., S.Y.C., A.J., L.Z., D.P.), University of Southern California, Los Angeles; and Department of Neurology (S.L.H.), University of California, San Francisco.
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Daniel Pelletier
From the Department of Neurology (C.J.A., S.Y.C., A.J., L.Z., D.P.), University of Southern California, Los Angeles; and Department of Neurology (S.L.H.), University of California, San Francisco.
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Citation
Contribution of normal aging to brain atrophy in MS
Christina J. Azevedo, Steven Y. Cen, Amir Jaberzadeh, Ling Zheng, Stephen L. Hauser, Daniel Pelletier
Neurol Neuroimmunol Neuroinflamm Nov 2019, 6 (6) e616; DOI: 10.1212/NXI.0000000000000616

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    Figure Contribution of normal aging to total atrophy in MS by decade

    Stacked histograms showing the trend of brain atrophy slopes by age in HCs (green) and MS-specific atrophy (blue). The total rate of atrophy in patients with MS is represented by the total height of each histogram bar (combining colors). For SIENA (A) and thalamus (B), the contribution of MS-specific atrophy and normal aging to the total atrophy slope changed significantly across decades, whereas normal aging was stable across decades in the caudate (C) and putamen (D). HC = healthy control; SIENA = structural image evaluation using normalization of atrophy.

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