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November 2019; 6 (6) ArticleOpen Access

Effects of natalizumab therapy on intrathecal antiviral antibody responses in MS

Fabienne Largey, Ivan Jelcic, Mireia Sospedra, Christoph Heesen, Roland Martin, Ilijas Jelcic
First published September 25, 2019, DOI: https://doi.org/10.1212/NXI.0000000000000621
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Article Information

vol. 6 no. 6 e621
DOI: 
https://doi.org/10.1212/NXI.0000000000000621
PubMed: 
31554671
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Online ISSN: 
2332-7812
History: 
  • Received August 15, 2018
  • Accepted in final form July 31, 2019
  • First Published September 25, 2019.
Copyright & Usage: 
Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Author Disclosures

    1. Fabienne Largey, PhD,
    2. Ivan Jelcic, PhD,
    3. Mireia Sospedra, PhD,
    4. Christoph Heesen, MD,
    5. Roland Martin, MD and
    6. Ilijas Jelcic, MD
  1. Fabienne Largey, PhD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. Celgene GmbH, Medical Affairs, 2 years (employment started after end of study)

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Ivan Jelcic, PhD,
    3. Scientific Advisory Boards:

    1. Dr. Ivan Jelcic received compensation for serving on a scientific advisory board by Sanofi Genzyme in 2018.

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Dr. Ivan Jelcic received speaker honoraria from the Swiss Society of Multiple Sclerosis (non-profit) in 2018.

    Editorial Boards:

    1. NONE

    Patents:

    1. Dr. Ivan Jelcic is listed as inventor on a patent of human monoclonal antibodies against JCPyV VP1 for the treatment of PML.

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Mireia Sospedra, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Invited editor of the special issue `Understanding and Elucidation of the Specificity of αβ-T cells`in Frontiers in Immunology

    Patents:

    1. Sospedra, M., Martin, R., Planas, R., Jelcic, I., Santos, R., Pinilla, C. IMMUNODOMINANT PROTEINS AND FRAGMENTS IN AUTOIMMUNE DISEASES. EP18180326.3 (2018). Jelcic, I., Martin, R., Schippling, S., Sospedra, M., Yousef, S. POLYOMA VIRUS JC PEPTIDES AND PROTEINS IN VACCINATION AND DIAGNOSTIC APPLICATIONS WO Patent 2,013,014,134 (2013)

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Christoph Heesen, MD,
    5. Scientific Advisory Boards:

    1. Ibsen Pharmaceuticals

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Received speaker honoraries from Biogen, Merck, Genzyme, Novartis

    Editorial Boards:

    1. International Journal of MS Care, 2014 until now

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. Received Research grants from Genzyme, Biogen, Roche, Novartis, Merck, Roche.

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Genzyme Sanofi Aventis Biogen Novartis Merck Roche

    Research Support, Government Entities:

    1. German Minstery of Research, PI 2012-2016 Hertie Foundation, PI 2014-2016 German Innovation Fond, PI 2018-2021

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NMSS

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Roland Martin, MD and
    6. Scientific Advisory Boards:

    1. I have received personal compensation for advisory work to Biogen, Merck & Serono, Teva, Genzyme Sanofi-Aventis, CellProtect, Neuway

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. I have received personal compensation/honoraria for speaking at workshops or small meetings by Biogen and Merck & Serono, Novartis, Roche, Genzyme, Teva, Sanofi-Aventis.

    Editorial Boards:

    1. NONE

    Patents:

    1. Together with B. Bielekova, H. McFarland and T. Waldmann I am a coholder of a patent claiming the therapeutic efficacy of anti-CD25 monoclonal antibody treatment in combination with IFN-b in MS. This patent is owned by NIH, but the patent holders receive periodic royalties. I have received royalties in the last five years. I am also inventor or co-inventor on University Zurich-held patents in the context of antigen-specific tolerization with peptide-coupled cells.

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. I have been consulting for the Myelin Repair Foundation, The Weatherall Institute for Molecular Studies, University of Oxford, the German Research Society, and the Hertie Foundation. These are all non-profit academic or private institutions, foundations. I am a member of the Kuratorium of the Jung Foundation for Science, Hamburg, Germany, also a non-profit organization; the Swiss Multiple Sclerosis Society, also non-profit, and several other national MS societies, in each case non-profit.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Novartis has given us financial support (unrestricted grant) to examine the effects of fingolimod on immune responses against herpes viruses. Biogen has given us financial support (unrestricted grant) to study the effects of natalizumab on the intrathecal antibody response in MS. We have also received unrestricted support for the department of neuroimmunology and MS research from Roche.

    Research Support, Government Entities:

    1. Swiss National Science Foundation (throughout last 7 years). European Union Seventh Framework Program. European Research Council Advanced Grant. Clinical Research Priority Program Multiple Sclerosis of the University Zurich for the last 6 years.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. I hold stock of CellProtect, a small biotech Company.

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. I had received royalty payments (periodically) from a NIH- Held patent on the use of anti-CD25 (daclizumab) in multiple sclerosis.

    Stock/Stock Options, Research Sponsor:

    1. I am Co-Founder and Co-Owner of Cellerys, a startup company out of Univ. Zurich, which is pursuing antigen-specific tolerization.

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Ilijas Jelcic, MD
    7. Scientific Advisory Boards:

    1. Neuway, Merck, Novartis and Sanofi Genzyme

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Novartis, speaker honoraria

    Editorial Boards:

    1. NONE

    Patents:

    1. Ivan J. and R.M. are listed as inventors on a patent of the human monoclonal antibodies against JCPyV VP1 for the treatment of PML. R.M., Ilijas J. and M.S. are listed as coinventors on a patent on vaccination against PML by immunisation with JCPyV VP1 protein.

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Novartis, unrestricted grant; Biogen, unrestricted grant (Biogen is the maker of Natalizumab, and has not imposed and has not tried to impose any restrictions on our submission of this work)

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Neuroimmunology and Multiple Sclerosis Research Section (F.L., Ivan Jelcic, M.S., R.M., Ilijas Jelcic), Department of Neurology, University Hospital of Zurich, Switzerland; and Institute for Neuroimmunology and Multiple Sclerosis (inims) (C.H.), Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  1. Correspondence
    Dr. Ilijas Jelcic Ilijas.Jelcic{at}usz.ch
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