Classifying the antibody-negative NMO syndromes
Clinical, imaging, and metabolomic modeling
Citation Manager Formats
Make Comment
See Comments

Article Information
- Received June 28, 2019
- Accepted in final form August 13, 2019
- First Published October 28, 2019.
Author Disclosures
- Tianrong Yeo, MRCP*,
- Fay Probert, PhD*,
- Maciej Jurynczyk, MD, PhD,
- Megan Sealey, PhD,
- Ana Cavey, CNS,
- Timothy D.W. Claridge, DPhil,
- Mark Woodhall, PhD,
- Patrick Waters, PhD,
- Maria Isabel Leite, MD, DPhil,
- Daniel C. Anthony, PhD† and
- Jacqueline Palace, FRCP, DM‡
- Tianrong Yeo, MRCP*,
NONE
NONE
ECTRIMS, Educational award to attend the 7th ECTRIMS Summer School 2019 ACTRIMS, Educational award to attend the ACTRIMS Forum 2019 Orebro University, Travel award to attend the 1st Nordic Metabolomics Conference 2018
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
Tianrong Yeo is supported by the Ministry of Health, Singapore through the National Medical Research Council Research Training Fellowship (NMRC/Fellowship/0038/2016).
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Fay Probert, PhD*,
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
1) MS Society
NONE
NONE
NONE
NONE
NONE
NONE
- Maciej Jurynczyk, MD, PhD,
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
I receive research fellowship from the Polish Ministry of Science and Higher Education programme Mobliność Plus (1070/MOB/2013/0).
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Megan Sealey, PhD,
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Ana Cavey, CNS,
Commercial. Coloplast. Neurogenic Nurse Advisory Board (UK). March 2014.
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Timothy D.W. Claridge, DPhil,
NONE
NONE
NONE
Magnetic Resonance in Chemistry, Advisory Board, 2017-present
NONE
High-Resolution NMR Techniques in Organic Chemistry (3rd Edn), Elsevier Science, 2016Introduction to Organic Spectroscopy, Oxford University Press, 1997
NONE
Infineum
NONE
NONE
NONE
NONE
NONE
University of Oxford John Fell Research Fund
Wellcome Trust Institutional Strategic Support Fund
NONE
NONE
NONE
NONE
NONE
NONE
- Mark Woodhall, PhD,
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Patrick Waters, PhD,
NONE
NONE
Honoraria from Biogen Idec, Retrogenix, Euroimmun AG, UBC, Alexion and Mereo Biopharma.
NONE
Assays for the detection of antibodies to lgi1, Caspr2, Tag-1 and GABAAR (g2 subunit).
NONE
NONE
NONE
NONE
NONE
NONE
Euroimmun AG
NONE
NONE
NONE
NONE
NONE
Patents for CASPR2, LGI1, TAG-1 and GABAAR (g2 subunit).
NONE
NONE
NONE
- Maria Isabel Leite, MD, DPhil,
NONE
NONE
Dr. Maria Isabel Leite is supported by NHS National Specialised Commissioning Group for Neuromyelitis Optica, UK, and by NIHR Oxford Biomedical Research Centre, and has received travel grant and speaking honoraria from Biogen Idec and travel grant from Novartis.
Neuromuscular Disorders, editorial board member, from January 2014
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Daniel C. Anthony, PhD† and
(1) Neuroplast
NONE
NONE
(1) Molecular and Cellular Neuroscience, Editorial board member, 2014- (no compensation)
(1) ISIS innovation Limited, a wholly-owned subsidiary of the University of Oxford, has filed a patent application (WO2013/117930 A2) to protect for the use of metabolomics as a method to diagnose and stage disease in multiple sclerosis.
NONE
NONE
NONE
NONE
NONE
NONE
(1) Hoffmann-La Roche (2) Numares (3) Merck
(1) MS Society; G59. PI, 2016-2019. High sensitivity staging and monitoring for multiple sclerosis utilising metabolomic analysis of blood.
(1) Lille2 University (2) University of Southern Denmark
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Jacqueline Palace, FRCP, DM‡
All commercial (advisory boards last 2 years) 1) Merck Serono 2) Roche 4) ARGENX 5) Chugai 6) Novartis Non-commercial 1) WIRMS)
NONE
All commercial (speakers/meetings honorarium last two years) 1) Merck Serono 2) Alexion 3) Novartis 4) ABIDE 5) MedImmune All commercial (conference support last two years) 5) Chugai 6) MedImmune 7) Alexion
NONE
ISIS Innovation Ltd. To protect for the use of metabolomics as a method to diagnose and stage disease in multiple sclerosis. Reference EP2812690B1
NONE
NONE
All commercial (advisory boards last two years) 1) Merck Serono 2) Roche 3) MedDay 4) Argenx 5) Chugai 6) Novartis Commercial (consultancy) 7) Merck Serono
Please see 3 (speaker/meetings)
NONE
NONE
All commercial (support for research) 1) Merck Serono
NONE
NONE
Grant for research: 1) Multiple Sclerosis Society 2) Guthry Jackson 3) Eugene Devic European Network 4) NIHR 5) ABIDE 6) Medical Research Council 7) MyWare Clinical Training Fellowship
NONE
NONE
NONE
NONE
NONE
NONE
- From the Department of Pharmacology (T.Y, F.P., M.S., D.C.A.), University of Oxford, UK; Department of Neurology (T.Y.), National Neuroscience Institute, Singapore; Nuffield Department of Clinical Neurosciences (M.J., A.C., M.W., P.W., M.I.L., J.P.), John Radcliffe Hospital, University of Oxford, UK; Department of Chemistry, (T.D.W.C.), Chemistry Research Laboratory, University of Oxford, UK.
- Correspondence
Prof. Palace jacqueline.palace{at}ndcn.ox.ac.uk or Prof. Anthony daniel.anthony{at}pharm.ox.ac.uk
Article usage
Cited By...
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Dr. Nicole Sur and Dr. Mausaminben Hathidara
► Watch
Related Articles
- No related articles found.
Topics Discussed
Alert Me
Recommended articles
-
Article
Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disordersDouglas Kazutoshi Sato, Dagoberto Callegaro, Marco Aurelio Lana-Peixoto et al.Neurology, January 10, 2014 -
Article
Antibodies to myelin oligodendrocyte glycoprotein in bilateral and recurrent optic neuritisSudarshini Ramanathan, Stephen W. Reddel, Andrew Henderson et al.Neurology - Neuroimmunology Neuroinflammation, October 29, 2014 -
Article
Fulminant demyelinating encephalomyelitisInsights from antibody studies and neuropathologyFranziska Di Pauli, Romana Höftberger, Markus Reindl et al.Neurology - Neuroimmunology Neuroinflammation, November 04, 2015 -
Article
Pregnancy in Patients With AQP4-Ab, MOG-Ab, or Double-Negative Neuromyelitis Optica DisorderNicolas Collongues, Cecilia Alves Do Rego, Bertrand Bourre et al.Neurology, February 24, 2021