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January 2020; 7 (1) ArticleOpen Access

Anti-NMDAR encephalitis

A single-center, longitudinal study in China

Xiaolu Xu, Qiang Lu, Yan Huang, Siyuan Fan, Lixin Zhou, View ORCID ProfileJing Yuan, Xunzhe Yang, Haitao Ren, Dawei Sun, Yi Dai, Huadong Zhu, Yinan Jiang, Yicheng Zhu, Bin Peng, Liying Cui, Hongzhi Guan
First published October 16, 2019, DOI: https://doi.org/10.1212/NXI.0000000000000633
Xiaolu Xu
From the Department of Neurology (X.X., Q.L., Y.H., S.F., L.Z., J.Y., X.Y., H.R., Y.Z., B.P., L.C., H.G.), Department of Gynecology and Obstetrics (D.S., Y.D.), Department of Emergency (H.Z.), and Department of Psychology (Y.J.), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; and Center of Neuroscience (L.C.), Chinese Academy of Medical Sciences.
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Qiang Lu
From the Department of Neurology (X.X., Q.L., Y.H., S.F., L.Z., J.Y., X.Y., H.R., Y.Z., B.P., L.C., H.G.), Department of Gynecology and Obstetrics (D.S., Y.D.), Department of Emergency (H.Z.), and Department of Psychology (Y.J.), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; and Center of Neuroscience (L.C.), Chinese Academy of Medical Sciences.
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Yan Huang
From the Department of Neurology (X.X., Q.L., Y.H., S.F., L.Z., J.Y., X.Y., H.R., Y.Z., B.P., L.C., H.G.), Department of Gynecology and Obstetrics (D.S., Y.D.), Department of Emergency (H.Z.), and Department of Psychology (Y.J.), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; and Center of Neuroscience (L.C.), Chinese Academy of Medical Sciences.
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Siyuan Fan
From the Department of Neurology (X.X., Q.L., Y.H., S.F., L.Z., J.Y., X.Y., H.R., Y.Z., B.P., L.C., H.G.), Department of Gynecology and Obstetrics (D.S., Y.D.), Department of Emergency (H.Z.), and Department of Psychology (Y.J.), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; and Center of Neuroscience (L.C.), Chinese Academy of Medical Sciences.
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Lixin Zhou
From the Department of Neurology (X.X., Q.L., Y.H., S.F., L.Z., J.Y., X.Y., H.R., Y.Z., B.P., L.C., H.G.), Department of Gynecology and Obstetrics (D.S., Y.D.), Department of Emergency (H.Z.), and Department of Psychology (Y.J.), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; and Center of Neuroscience (L.C.), Chinese Academy of Medical Sciences.
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Jing Yuan
From the Department of Neurology (X.X., Q.L., Y.H., S.F., L.Z., J.Y., X.Y., H.R., Y.Z., B.P., L.C., H.G.), Department of Gynecology and Obstetrics (D.S., Y.D.), Department of Emergency (H.Z.), and Department of Psychology (Y.J.), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; and Center of Neuroscience (L.C.), Chinese Academy of Medical Sciences.
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  • ORCID record for Jing Yuan
Xunzhe Yang
From the Department of Neurology (X.X., Q.L., Y.H., S.F., L.Z., J.Y., X.Y., H.R., Y.Z., B.P., L.C., H.G.), Department of Gynecology and Obstetrics (D.S., Y.D.), Department of Emergency (H.Z.), and Department of Psychology (Y.J.), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; and Center of Neuroscience (L.C.), Chinese Academy of Medical Sciences.
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Haitao Ren
From the Department of Neurology (X.X., Q.L., Y.H., S.F., L.Z., J.Y., X.Y., H.R., Y.Z., B.P., L.C., H.G.), Department of Gynecology and Obstetrics (D.S., Y.D.), Department of Emergency (H.Z.), and Department of Psychology (Y.J.), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; and Center of Neuroscience (L.C.), Chinese Academy of Medical Sciences.
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Dawei Sun
From the Department of Neurology (X.X., Q.L., Y.H., S.F., L.Z., J.Y., X.Y., H.R., Y.Z., B.P., L.C., H.G.), Department of Gynecology and Obstetrics (D.S., Y.D.), Department of Emergency (H.Z.), and Department of Psychology (Y.J.), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; and Center of Neuroscience (L.C.), Chinese Academy of Medical Sciences.
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Yi Dai
From the Department of Neurology (X.X., Q.L., Y.H., S.F., L.Z., J.Y., X.Y., H.R., Y.Z., B.P., L.C., H.G.), Department of Gynecology and Obstetrics (D.S., Y.D.), Department of Emergency (H.Z.), and Department of Psychology (Y.J.), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; and Center of Neuroscience (L.C.), Chinese Academy of Medical Sciences.
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Huadong Zhu
From the Department of Neurology (X.X., Q.L., Y.H., S.F., L.Z., J.Y., X.Y., H.R., Y.Z., B.P., L.C., H.G.), Department of Gynecology and Obstetrics (D.S., Y.D.), Department of Emergency (H.Z.), and Department of Psychology (Y.J.), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; and Center of Neuroscience (L.C.), Chinese Academy of Medical Sciences.
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Yinan Jiang
From the Department of Neurology (X.X., Q.L., Y.H., S.F., L.Z., J.Y., X.Y., H.R., Y.Z., B.P., L.C., H.G.), Department of Gynecology and Obstetrics (D.S., Y.D.), Department of Emergency (H.Z.), and Department of Psychology (Y.J.), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; and Center of Neuroscience (L.C.), Chinese Academy of Medical Sciences.
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Yicheng Zhu
From the Department of Neurology (X.X., Q.L., Y.H., S.F., L.Z., J.Y., X.Y., H.R., Y.Z., B.P., L.C., H.G.), Department of Gynecology and Obstetrics (D.S., Y.D.), Department of Emergency (H.Z.), and Department of Psychology (Y.J.), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; and Center of Neuroscience (L.C.), Chinese Academy of Medical Sciences.
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Bin Peng
From the Department of Neurology (X.X., Q.L., Y.H., S.F., L.Z., J.Y., X.Y., H.R., Y.Z., B.P., L.C., H.G.), Department of Gynecology and Obstetrics (D.S., Y.D.), Department of Emergency (H.Z.), and Department of Psychology (Y.J.), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; and Center of Neuroscience (L.C.), Chinese Academy of Medical Sciences.
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Liying Cui
From the Department of Neurology (X.X., Q.L., Y.H., S.F., L.Z., J.Y., X.Y., H.R., Y.Z., B.P., L.C., H.G.), Department of Gynecology and Obstetrics (D.S., Y.D.), Department of Emergency (H.Z.), and Department of Psychology (Y.J.), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; and Center of Neuroscience (L.C.), Chinese Academy of Medical Sciences.
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Hongzhi Guan
From the Department of Neurology (X.X., Q.L., Y.H., S.F., L.Z., J.Y., X.Y., H.R., Y.Z., B.P., L.C., H.G.), Department of Gynecology and Obstetrics (D.S., Y.D.), Department of Emergency (H.Z.), and Department of Psychology (Y.J.), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; and Center of Neuroscience (L.C.), Chinese Academy of Medical Sciences.
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Full PDF
Citation
Anti-NMDAR encephalitis
A single-center, longitudinal study in China
Xiaolu Xu, Qiang Lu, Yan Huang, Siyuan Fan, Lixin Zhou, Jing Yuan, Xunzhe Yang, Haitao Ren, Dawei Sun, Yi Dai, Huadong Zhu, Yinan Jiang, Yicheng Zhu, Bin Peng, Liying Cui, Hongzhi Guan
Neurol Neuroimmunol Neuroinflamm Jan 2020, 7 (1) e633; DOI: 10.1212/NXI.0000000000000633

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Article Information

vol. 7 no. 1 e633
DOI: 
https://doi.org/10.1212/NXI.0000000000000633
PubMed: 
31619447

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Online ISSN: 
2332-7812
History: 
  • Received April 21, 2019
  • Accepted in final form September 12, 2019
  • First Published October 16, 2019.

Copyright & Usage: 
Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Author Disclosures

    1. Xiaolu Xu, MD*,
    2. Qiang Lu, MD*,
    3. Yan Huang, MD,
    4. Siyuan Fan, MD,
    5. Lixin Zhou, MD,
    6. Jing Yuan, MD,
    7. Xunzhe Yang, MD,
    8. Haitao Ren, BS,
    9. Dawei Sun, MD,
    10. Yi Dai, MD,
    11. Huadong Zhu, MD,
    12. Yinan Jiang, MD,
    13. Yicheng Zhu, MD,
    14. Bin Peng, MD,
    15. Liying Cui, MD and
    16. Hongzhi Guan, MD
  1. Xiaolu Xu, MD*,
  2. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. Qiang Lu, MD*,
  4. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. Yan Huang, MD,
  6. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  7. Siyuan Fan, MD,
  8. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  9. Lixin Zhou, MD,
  10. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  11. Jing Yuan, MD,
  12. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  13. Xunzhe Yang, MD,
  14. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  15. Haitao Ren, BS,
  16. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  17. Dawei Sun, MD,
  18. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. 1. Chinese Journal of Laparoscopic Surgery, Associate Editor

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  19. Yi Dai, MD,
  20. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  21. Huadong Zhu, MD,
  22. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. 1.World Journal of Emergency Medicine, editorial board member 2.Chinese Journal of Critical Care Medicine, editorial board member 3. Chinese Critical Care Medicine, corresponding editor 4.Medical Journal Of Peking Union Medical College Hospital(Chinese),editorial board member

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  23. Yinan Jiang, MD,
  24. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  25. Yicheng Zhu, MD,
  26. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. receiving research support from National Key Technology R&D Program in the 12th Five year Plan of China. Grant number: 2011BAI08B03

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  27. Bin Peng, MD,
  28. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. 1.Chinese Journal of Neurology,Associate Editor, 2.Chinese Journal of Cerebrovascular Diseases, Associate Editor, 3. Stroke and Vascular Neurology, Editorial Board Member

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  29. Liying Cui, MD and
  30. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  31. Hongzhi Guan, MD
  32. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. 1.National Medical Journal of China(Chinese),corresponding editor

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. 1.National Key Research and Development Program of China (Grant No. 2016YFC0901500) 2.Center for Rare Diseases Research, Chinese Academy of Medical Sciences, Beijing, China (Grant No. 2016ZX310174-4) 3.Beijing Municipal Science and Technology Foundation (Grant No. Z161100000516094) Role of funding sources: The study sponsors had no role in the study design, data collection, data analysis, data interpretation, or writing of the report.

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  1. From the Department of Neurology (X.X., Q.L., Y.H., S.F., L.Z., J.Y., X.Y., H.R., Y.Z., B.P., L.C., H.G.), Department of Gynecology and Obstetrics (D.S., Y.D.), Department of Emergency (H.Z.), and Department of Psychology (Y.J.), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; and Center of Neuroscience (L.C.), Chinese Academy of Medical Sciences.
  1. Correspondence
    Dr. Guan guanhz{at}263.net
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