Article Figures & Data
Figures
- Figure 1 The number of patients with ≥2 attacks based on the rate of attacks with optic neuritis (ON)
ON = optic neuritis
- Figure 2 Clinical course and relapses in each of the patients with ≥3 attacks (n = 43)
The presented clinical courses imply a clustered occurrence of attacks, irrespective of the duration from clinical onset.
- Figure 3 Tendency of clustered attacks in NMOSD, irrespective of treatments
(A) Histograms of the months between 2 tandem attacks (black bars) and the months of relapse-free period by June 2019 (white bars) in all 69 enrolled patients. The center of the gray-colored diamond is the average and its width is the standard error (SE). (B) Histogram of the months between 2 tandem attacks during the medication-free period. (C) Histogram of the months between 2 tandem attacks during the treatment period with oral relapse-preventive therapy. NMOSD = neuromyelitis optica spectrum disorder.
- Figure 4 Kaplan-Meier survival analysis comparing relapse-free periods without medications between 0 and 24 months from onset and later
The analysis compared the relapse-free period without relapse-preventive therapies between 0 and 24 months from the onset (36 patients with no relapse-preventive therapy) and 24–48 months from the onset (14 patients without relapses in the first 24 months). The latter group represents the “nonclustered” intermittent period status. The former group showed a shorter relapse-free period and a higher relapse rate than the latter group (p = 0.0206, generalized Wilcoxon test).
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