Clinical approach to the diagnosis of autoimmune encephalitis in the pediatric patient
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Article Information
- Received July 31, 2019
- Accepted in final form November 25, 2019
- First Published January 17, 2020.
Author Disclosures
- Tania Cellucci, MD, MScCH,
- Heather Van Mater, MD, MSc,
- Francesc Graus, MD, PhD,
- Eyal Muscal, MD, MS,
- William Gallentine, DO,
- Marisa S. Klein-Gitelman, MD, MPH,
- Susanne M. Benseler, MD, PhD,
- Jennifer Frankovich, MD, MS,
- Mark P. Gorman, MD,
- Keith Van Haren, MD,
- Josep Dalmau, MD, PhD and
- Russell C. Dale, MBChB, MSc, PhD
- Tania Cellucci, MD, MScCH,
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- Heather Van Mater, MD, MSc,
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- Francesc Graus, MD, PhD,
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Assistant Editor MedLink Neurology
licensing fee from Euroimmun for the use of IgLON5 as an autoantibody test
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- Eyal Muscal, MD, MS,
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(1) Lupus Foundation of America
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- William Gallentine, DO,
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- Marisa S. Klein-Gitelman, MD, MPH,
GRAPPA (non-profit)
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UpToDate 2011-present
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UpToDate 2011- present Section Editor/Author pediatric rheumatology sections
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Board Member, American College of Rheumatology
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- Susanne M. Benseler, MD, PhD,
(1) The Arthritis Society, Autoimmune Encephalitis Alliance, Vasculitis Foundation (2) Novartis, Sobi
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(1) The Arthritis Society (travel, no honorarium) (2) Novartis, Sobi (travel, no honorarium)
Neurology: Neuroimmunology & Neuroinflammation
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- Jennifer Frankovich, MD, MS,
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(1)Yale University/NIH, GR106053, Site PI, 2 years
Stanford SPARK Program Stanford Maternal and Child Health Research Institute
PANS/PANDAS Physician Network PRAI Kids Global Lyme Alliance Lucile Packard Foundation for Children's Health Caudwell Children's Foundation
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- Mark P. Gorman, MD,
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(1) Pfizer, (2)Novartis, (3) Roche
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National Multiple Sclerosis Society (Grant numbers 70846, 73216)
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- Keith Van Haren, MD,
Scientific Advisory Board - The Myelin Project (unpaid)Board of Directors - ALD Connect (unpaid)DSMB for Phase I/II trial of NV1205 in ALD - Neurovia (paid)
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January 2017 - Due diligence review for ENSO Ventures regarding investment in NV1209June 2018 - Scientific consulting for Viking Pharma on ALD scientific program
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NIH K23NS087151 (PI, July 2015 - present)
(1) Stanford University Dept of Neurology
(1) Packard Foundation Sprague/McHugh Award for MS Research (June 2011 to present)(2) Child Neuorology Foundation - Scientific Award - Jan 2012 - June 2015)
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- Josep Dalmau, MD, PhD and
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Neurology, Neuroimmunology and Neuroinflammation Neurology UpToDate
Patent for Ma2 autoantibody test: US 6,387,639; Issued May 14th, 2002. Patent for NMDA receptor autoantibody test: US 7,972,796 B2 July 5, 2011; European 2057466. Patent for GABAb receptor autoantibody test: US 8,685,656; European 2483417; Patents filed for GABA(A) receptor autoantibody test, DPPX autoantibody test, and IgLON5 autoantibody test.
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Advance Medical
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-NIH, RO1NS077851, PI, 2011-2018 -Instituto Carlos III/FEDER (FIS, 14/00203 and CIBERER CB15/00010, and Proyectos Integrados de Excelencia, PIE 16/00014). -Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR), and CERCA Programme Generalitat de Catalunya -ERA-NET Neuron
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Safra Foundation Sage therapeutics Cellex Foundation La Caixa Health Foundation
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NMDA receptor autoantibody test/Euroimmun GABA(B)R autoantibody test/Euroimmun GABA(A)R autoantibody test/Euroimmun DPPX autoantibody test/Euroimmun Iglon5 autoantibody test/Euroimmun
Patent Ma2 autoantibody test Patent NMDAR autoantibody test Patent GABA(B) receptor autoantibody test Patent application for the use of GABA(A) receptor, DPPX and IgLON5 autoantiboddy tests
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- Russell C. Dale, MBChB, MSc, PhD
National Blood Authority. Federal, not for profit
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received an honoraria for lecturing from Biogen Idec and Bristol-Myers-Squibb
Editorial advisory board member of MSARDEditorial board member of Neurology: Neuroimmunology and NeuroinflammationEditorial board member of European Journal of Paediatric Neurology
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Biogen Idec honoraria in 2008 and Bristol-Myers-Squibb in 2015
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NHMRC national grant in 2011 national grant for encephalitis studyNHMRC practitioner fellowship 2014-8NHMRC project grant 2015, 2018NHMRC partnership grant 2018
Multiple Sclerosis Research Australia 2015
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- From the Department of Pediatrics (T.C.), McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada; Department of Pediatrics (H.V.M.), Duke University, Durham, NC; Neuroimmunology Program (F.G., J.D.), Institut d'Investigacions Biomèdiques August Pi I Sunyer, Barcelona, Spain; Department of Pediatrics (E.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (W.G., K.V.H.), Lucile Packard Children's Hospital, Stanford University, Palo Alto, CA; Division of Rheumatology (M.S.K.-G.), Ann & Robert H, Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, IL; Department of Pediatrics (S.M.B.), Alberta Children's Hospital, University of Calgary, Canada; Division of Pediatric Allergy, Immunology and Rheumatology (J.F.), Lucile Packard Children's Hospital, Stanford University, Palo Alto, CA; Department of Neurology (M.P.G.), Boston Children's Hospital, Harvard University, MA; Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; Catalan Institution for Research and Advanced Studies (ICREA) (J.D.); Neuroimmunology Group (R.C.D.), Children's Hospital at Westmead, Faculty of Medicine and Health, University of Sydney, New South Wales, Australia.
- Correspondence
Dr. Dale Russell.dale{at}health.nsw.gov.au
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