Covarying patterns of white matter lesions and cortical atrophy predict progression in early MS
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Article Information
- Received July 11, 2019
- Accepted in final form January 7, 2020
- First Published February 5, 2020.
Author Disclosures
- Muthuraman Muthuraman, PhD*,
- Vinzenz Fleischer, MD*,
- Julia Kroth, MD*,
- Dumitru Ciolac, MD,
- Angela Radetz, MSc,
- Nabin Koirala, PhD,
- Gabriel Gonzalez-Escamilla, PhD,
- Heinz Wiendl, MD,
- Sven G. Meuth, PhD, MD,
- Frauke Zipp, MD† and
- Sergiu Groppa, MD†
- Muthuraman Muthuraman, PhD*,
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- Vinzenz Fleischer, MD*,
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- Julia Kroth, MD*,
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- Dumitru Ciolac, MD,
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- Angela Radetz, MSc,
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- Nabin Koirala, PhD,
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- Gabriel Gonzalez-Escamilla, PhD,
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- Heinz Wiendl, MD,
(1) Biogen, (2) Evgen (3) MedDay Pharmaceuticals (4) Merck Serono (5) Novartis (6) Roche Pharma AG (7) Sanofi-Genzyme
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(1) Alexion (2) Biogen (3) Cognomed (4) F. Hoffmann-La Roche Ltd. (5) Gemeinnützige Hertie-Stiftung (6) Merck Serono (7) Novartis (8) Roche Pharma AG (9) Sanofi-Genzyme (10) TEVA (11) WebMD Global
(1) PLOS ONE, Editorial board member, since 2013 (2) Neurotherapeutics, since 2013 (3) Recent Patents on Inflammation & Allergy Drug Discovery
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(1) Abbvie (2) Biogen (3) IGES (4) Johnson & Johnson (5) Merck (6) Novartis (7) Roche (8) Sanofi-Genzyme (9) Swiss Multiple Sclerosis Society
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(1) Bayer Healthcare (2) Bayer Vital (3) Biogen (4) Merck Serono (5) Novartis (6) Sanofi  Genzyme (7) Sanofi US (8) TEVA Pharma
(1) German Ministry for Education and Research (BMBF), 01GI1601E, principal investigator, 2016-2019 (2)Interdisciplinary Centre of Clinical Research (IZKF) Muenster, principal investigator, 2015-2018 (4)PML Consortium, principal investigator, 2016-2018 (5) German Research Foundation, principal investigator,SFB 1009 TP A3 + SFB-TR CRC128 TP A09 + SFB TR CRC128 TP A10, TR CRC128 TP V, TR CRC128 TP Z02 2016- 2020
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(1) Else Kröner Fresenius Foundation (2) Fresenius Foundation (3) Hertie Foundation (4) RE ChildrenÂs Foundation
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- Sven G. Meuth, PhD, MD,
(1) German association for Multiple Sclerosis (2) German Society for Neurology (DGN)(3) Neurology Trust (4) Center for Clinical Studies (ZKS) (5) Max Planck Society
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Sven Meuth receives honoraria for lecturing, and travel expenses for attending meetings from Almirall, Amicus Therapeutics Germany, Bayer Health Care, Biogen, Celgene, Diamed, Genzyme, MedDay Pharmaceuticals, Merck Serono, Novartis, Novo Nordisk, ONO Pharma, Roche, Sanofi- Aventis, Chugai Pharma, QuintilesIMS and Teva.
(1) PLoS One (editor) (2) DGNeurologie, founding member editorial board
(1)Effectivity of specific FXII/FXIIa inhibitors, particularly rHA-Infestin 4 used to treat neuro- inflammatoral diseases (WO 2013/113774 A1 and EP 2 263 110 A1) (2) Diagnosis of a novel autoimmune disease (European patent; 15001186.4  1402) (3)"NR2B selective NMDA-receptor Antagonists for Treatment of immune-mediated inflammatory diseases (Reference number: PCT/EP2016/069975)
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Sven Meuth receives honoraria for lecturing, and travel expenses for attending meetings from Almirall, Amicus Therapeutics Germany, Bayer Health Care, Biogen, Celgene, Diamed, Genzyme, MedDay Pharmaceuticals, Merck Serono, Novartis, Novo Nordisk, ONO Pharma, Roche, Sanofi- Aventis, Chugai Pharma, QuintilesIMS and Teva.
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Research is funded by Almirall, Amicus Therapeutics Germany, Biogen, Diamed, Fresenius Medical Care, HERZ Burgdorf, Genzyme, Merck Serono, Novartis, ONO Pharma, Roche, and Teva.
Research is funded by the German Ministry for Education and Research (BMBF), Deutsche Forschungsgesellschaft (DFG), German Academic Exchange Service, Interdisciplinary Center for Clinical Studies (IZKF) Muenster, German Foundation Neurology, Bundesinstitut für Risikobewertung; Gemeinsamer Bundesausschuss
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Research is funded by Else Kröner Fresenius Foundation, Hertie Foundation
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- Frauke Zipp, MD† and
(1) MPG (2) Merck Serono (3) Roche (4) Novartis (5) Sanofi- Aventis (6) Celgene (7) ONO (8) Octapharma
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(1) MPG (2) Merck Serono (3) Roche (4) Novartis (5) Sanofi- Aventis (6) Celgene (7) ONO (8) Octapharma
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(1) Genzyme
(1) DFG CRC-TRR 128, Co-Spokesperson/Spokesperson, 2012-2020 (2) DFG CRC1080, PI, 2013-2020 (3) BMBF KKNMS, PI, 2013-2019
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(1) Progressive MS Alliance, BRAVEinMS
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- Sergiu Groppa, MD†
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Nature scientific reports editor 2018
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- From the Department of Neurology (M.M., V.F., J.K., D.C., A.R., N.K., G.G.-E., F.Z., S.G.), Focus Program Translational Neuroscience (FTN), Research Center for Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz; and Department of Neurology with Institute of Translational Neurology (H.W., S.G.M.), University of Munster, Germany.
- Correspondence
Dr. Groppa segroppa{at}uni-mainz.de
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