Article Figures & Data
Figures
- Figure 1 Data analysis flowchart
(A) WM lesion volumes derived from structural MRI data sets (T1W, T2W FLAIR) and (B) cortical atrophy rates (FreeSurfer processing) from the same patients were used as inputs for the pattern identification analysis. The weights were assigned based on the correlation between these 2 parameters. Parallel ICA was performed, and distinct covarying lesion patterns of cortical atrophy and WM lesions were identified. For each lesion pattern, the component loads of each patient related to cortical atrophy (brown line) and WM lesion volume (green line) were correlated. FLAIR = fluid-attenuated inversion recovery; ICA = independent component analysis; T1W = T1‐weighted; T2W = T2‐weighted; WM = white matter.
- Figure 2 Three significant covarying patterns of regional cortical atrophy and the corresponding WM lesion volume
(A) Cerebellar lesion pattern, (B) bihemispheric lesion pattern, and (C) left-lateralized lesion pattern. WM = white matter.
- Figure 3 Comparison of ROC curves showing the accuracy of covarying lesion patterns in predicting disability progression
The shadowed areas represent the 95% CIs. In the legend, the AUC and the 95% CIs are presented. The cerebellar pattern shows the best accuracy in predicting disability progression over time in comparison to the bihemispheric and left-lateralized patterns (*p < 0.05). AUC = area under the curve.
- Figure 4 Map of the cerebellar lesion distribution
Here, each particular voxel shows how this region contributes to the prediction analysis for disease progression in the study cohort (A) and in the replication cohort (B). Color bar indicates the component load of the cerebellar pattern. (C) shows the Buckner 7-network cerebellar nuclei atlas, and (D) represents the corresponding cortical connectivity map. ICA = independent component analysis.
Letters: Rapid online correspondence
REQUIREMENTS
If you are uploading a letter concerning an article:
You must have updated your disclosures within six months: http://submit.neurology.org
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Use of Whole-Genome Sequencing for Mitochondrial Disease Diagnosis
Dr. Robert Pitceathly and Dr. William Macken
► Watch
Topics Discussed
Alert Me
Recommended articles
Network Damage Predicts Clinical Worsening in Multiple Sclerosis
Cortical atrophy accelerates as cognitive decline worsens in multiple sclerosis
Association of Gray Matter Atrophy Patterns With Clinical Phenotype and Progression in Multiple Sclerosis
What's happening in Neurology® Neuroimmunology & Neuroinflammation