Serum neurofilament light chain and optical coherence tomography measures in MS
A longitudinal study
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Article Information
- Received November 5, 2019
- Accepted in final form April 9, 2020
- First Published May 18, 2020.
Author Disclosures
- Eleonora Tavazzi, MD,
- Dejan Jakimovski, MD, PhD,
- Jens Kuhle, MD, PhD,
- Jesper Hagemeier, PhD,
- Osman Ozel, MD,
- Murali Ramanathan, PhD,
- Christian Barro, MD, PhD,
- Niels Bergsland, PhD,
- Davorka Tomic, MD,
- Harald Kropshofer, MD,
- David Leppert, MD,
- Zuzanna Michalak, PhD,
- Norah Lincoff, MD,
- Michael G. Dwyer, PhD,
- Ralph H.B. Benedict, PhD,
- Bianca Weinstock-Guttman, MD and
- Robert Zivadinov, MD, PhD
- Eleonora Tavazzi, MD,
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- Dejan Jakimovski, MD, PhD,
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- Jens Kuhle, MD, PhD,
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(1) Bayer AG (2) Biogen (3) Celgene (4) Genzyme (5) Merck (4) Novartis (5) Roche Pharma (Schweiz) AG
(1) Swiss National Research Foundation (320030_189140/1)
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(1) ECTRIMS Research Fellowship Programme (2) University of Basel (3) Swiss MS Society
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- Jesper Hagemeier, PhD,
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- Osman Ozel, MD,
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- Murali Ramanathan, PhD,
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The AAPS Journal
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Pinnacle, Summit and Zenith, The Pharmacy Calculations Workbook, 2008
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Otsuka Pharmaceutical
Department of Defense, National Science Foundation, National Institutes of Health
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- Christian Barro, MD, PhD,
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- Niels Bergsland, PhD,
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1) Journal of Neuroimaging, Section editor for multiple sclerosis, 2018-present 2) PLOS ONE, Academic Editor, 2018-present 3) Journal of Magnetic Resonance Imaging, Associate Editor, 2018-present
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- Davorka Tomic, MD,
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Patent on fingolimod's activity on T1 hypointense lesions (black holes)
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Novartis Pharma AG; Global Brand Medical Director (Medical Affairs), July 2011-March 2020 - position is related to this manuscript Merck KGaA; Senior Medical Director, from 15 April 2020 (position is not related to this manuscript)
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I am former employee of Novartis Pharma AG and hold stock in Novartis Pharma AG
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- Harald Kropshofer, MD,
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(19 Novartis Pharma AG, employee, 4 years.
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- David Leppert, MD,
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Travel cost reimbursement and speaker honoraria from Sanofi, GeNeuro, Roche, Novartis and Orion
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David Leppert has been a Novartis employee until January 2019.
DL is a consultant for GeNeuro.
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David Leppert has been a Novartis employee until January 2019. Stock/Stock Options, Medical Equipment & Materials: Novartis granted 2019 blocked until 2022
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- Zuzanna Michalak, PhD,
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F.Hoffmann-La Roche Ltd, Scientist, 2019-present
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- Norah Lincoff, MD,
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- Michael G. Dwyer, PhD,
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Assistant Editor, Journal of Neuroimaging
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(1) Protembis GmbH (2) EMD Serono (3) Keystone Heart
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(1) Novartis (2) Celgene (3) Protembis (4) Keystone Heart
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- Ralph H.B. Benedict, PhD,
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Editorial Board, Multiple Sclerosis, Journal of the International Neuropsychological Society
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Brief Visuospatial Memory Test (Psychological Assessment Resources, 1997)
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Provided consultancy for (1) Biogen, (2) Celgene, (3) Medday, (4) Novartis, (5) Roche, (6) Sanofi, and (7) Verasci.
Received honoraria or speaking fees from (1) Biogen, (2) Celgene, (3) EMD Serono and (4) Novartis
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Performs neuropsychological testing as part of his clinical practice (40% effort) and bills for this practice.
Received research support from (1) Biogen, (2) Genentech, (3) Genzyme, (4) Mallinckrodt, and (5) Novartis
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National Multiple Sclerosis Society
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Testified several times in personal injury trials
- Bianca Weinstock-Guttman, MD and
Novartis, Genentech
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Advisory board for :Biogen, EMD Serono, Novartis, Genentech, Mallinckrodt, Abbvie, Celgene
Biogen & Idec; Novartis, Genentech, EMD Serono
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research grants from Biogen Idec, EMD Serono, Novartis, Genentech, Mallickrodt
PCORI NMSS
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National MS Society, Clinical grant for Pediatric MS
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- Robert Zivadinov, MD, PhD
R Zivadinov received personal compensation from Genzyme-Sanofi, Celgene and Novartis for serving on scientific advisory board.
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R Zivadinov received personal compensation from EMD Serono, Inc., Novartis, Sanofi-Genzyme,Celgene for speaking
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R Zivadinov received personal compensation from EMD Serono, Inc., Novartis, Sanofi-Genzyme for consulting fees.
R Zivadinov received personal compensation from EMD Serono, Inc., Novartis, Sanofi-Genzyme for speaking
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Dr. Zivadinov: financial support for research activities from EMD Serono, Inc., Novartis, Sanofi-Genzyme,Mapi Pharma, Celgene and Protembis.
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- From the Buffalo Neuroimaging Analysis Center (E.T., D.J., J.H., O.O., N.B., M.G.D., R.Z.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York; IRCCS (N.B.), Fondazione Don Carlo Gnocchi, Milan, Italy; Neurologic Clinic and Policlinic (J.K., C.B., Z.M., N.L.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Switzerland; Department of Pharmaceutical Sciences (M.R.), Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York; Novartis Pharma AG (D.T., H.K., D.L.), Basel, Switzerland; Jacobs MS Center (R.H.B.B., B.W.-G.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, and Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York.
- Correspondence
Dr. Zivadinov rzivadinov{at}bnac.net
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