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July 2020; 7 (4) ArticleOpen Access

Brain amyloid in virally suppressed HIV-associated neurocognitive disorder

Gemma C. Howdle, Yann Quidé, Mustafa S. Kassem, Kate Johnson, Caroline D. Rae, Bruce J. Brew, Lucette A. Cysique
First published May 11, 2020, DOI: https://doi.org/10.1212/NXI.0000000000000739
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Article Information

vol. 7 no. 4 e739
DOI: 
https://doi.org/10.1212/NXI.0000000000000739
PubMed: 
32393651
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Online ISSN: 
2332-7812
History: 
  • Received October 7, 2019
  • Accepted in final form April 6, 2020
  • First Published May 11, 2020.
Copyright & Usage: 
Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Author Disclosures

    1. Gemma C. Howdle, BA&Sc,
    2. Yann Quidé, PhD,
    3. Mustafa S. Kassem, PhD,
    4. Kate Johnson, MD,
    5. Caroline D. Rae, PhD,
    6. Bruce J. Brew, MD, DSc, FRACP, FAAN and
    7. Lucette A. Cysique, PhD
  1. Gemma C. Howdle, BA&Sc,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Yann Quidé, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Mustafa S. Kassem, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Kate Johnson, MD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. St Vincent's Hospital Darlinghust, neurology research fellow, 2019-presentSydney Adventist Hospital, neurology registrar, 2020- presentHornsby Hospital, casual medical registrar, 2020 to present

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. Sydney University, Masters of Philosophy by research, student, RTP scholarship

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Caroline D. Rae, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. 1) Travel costs, Philips Healthcare

    Editorial Boards:

    1. 1. Neurochemical Research, Associate Editor 2015-192. Neurochemistry International, Associate Editor 2017-current3. Editorial Board, Magnetic Resonance in Medicine 2017 - current.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Bruce J. Brew, MD, DSc, FRACP, FAAN and
    7. Scientific Advisory Boards:

    1. Biogen IdecViivJohnson and Johnson

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Biogen Idec speaker honorariaJohnson and Johnson honoraria

    Editorial Boards:

    1. International Journal for Tryptophan Research, member 2008-Faculty of 1000 Medicine member 2008-Journal of Neurovirology, member 2009-Neurobehavioral HIV Medicine, member 2009-AIDS 2017-Lancet HIV 2017-

    Patents:

    1. Monoclonal antibody for Quinolinic acid as part of test kit for monitoring MS severity and progression (PCT/IB2013/055902;

    Publishing Royalties:

    1. Oxford University Press for HIV NeurologyCambridge University Press for Palliative management in neurological disorders: a practical guide.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. GlaxoSmithKline, speaker, 2005-2009ViiV Healthcare, 2010, 2016 Boehringer Ingelheim, 2005-2010 Abbott, 2009-2010, 2015 Biogen Idec 2006, 2008Novartis 2017

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Biogen Idec

    Research Support, Government Entities:

    1. NIH, NHMRC

    Research Support, Academic Entities:

    1. UNSW

    Research Support, Foundations and Societies:

    1. St Vincent's Clinic Research Foundation 2009-2018

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Lucette A. Cysique, PhD
    8. Scientific Advisory Boards:

    1. 1. one NIH funded study

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Editorial Board Member for following journals: The Journal of Aids & Clinical Research – Open access, The Journal of Sexually Transmitted Diseases, Editorial Board Member The World Journal of Neurology, Editorial Board Member Biomed Research International Plos One Journal of Neurovirology

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. 1. I consult for the Missouri Mental Health Institute, Missouri University, Saint Louis, MO, USA

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1. (APP1105808) NHMRC project grant (Bruce Brew) (A$814,000) Identification and quantification of HIV Latency biomarkers in the Central Nervous System. 01/2016 – 12/2019 Role: CIB, Principal Co-Investigator (Cysique leading study neuropsychologist, neuroimager) 2. CIHR, HIV/AIDS Community-Based Research Program. Worthington, Chan Carusone, Rourke,Ibáñez-Carrasco, Cysique. (CAD $449,980) 05/2019-05-2022. HEADS UP! 2: A qualitative CBR study to describe service experiences of HIV positive people living with neurocognitive difficulties and disorders and the providers of those services. Role: Cysique – co-investigator 3. Sexual Health Research Fund (SHRF) Queensland Health (Queensland Sexual Health Strategy 2016-2021). (CIA: Adina Piovesana) 01/08/19 to 30/08/2020 (A$80,040). Enhancing pathways, workforce and capacity for HAND (HIV-Associated Neurocognitive Disorders) assessment for people living with HIV (PLHIV) throughout Qld-including regional. Role: Cysique – co- investigator, Neuropsychology lead

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1. Brain foundation (CIA: Lauriane Jugé, post-doc) 1.1.2020- 31.12.2020 (A$ 24,000). Early detection of cerebral small vessel disease. Role: Cysique – co-investigator, Vascular brain injury research lead

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Neuroscience Research Australia (G.C.H., Y.Q., M.S.K., C.D.R., L.A.C.), Randwick; School of Psychiatry (Y.Q.), UNSW Sydney; School of Medical Sciences (M.S.K., C.D.R, B.J.B), UNSW Sydney; Peter Duncan Neuroscience Research Unit (K.J., B.J.B, L.A.C), St. Vincent's Centre for Applied Medical Research; Departments of Neurology and Immunology (K.J., B.J.B.), St. Vincent's Hospital, Darlinghurst, Australia; and School of Psychology (L.A.C.), UNSW Sydney, NSW, Australia.
  1. Correspondence
    Dr. Cysique lcysique{at}unsw.edu.au
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