Article Figures & Data
Figures
- Figure 1 Three-dimensional foveal shape analysis method overview
(A) ILM surface smoothing and radial reconstruction using the cubic Bezier polynomial. (B) Rim height, average pit depth, and central foveal thickness. (C) Rim disk (blue), slope disk (red), and pit flat disk (green) and major and minor axes on each surface. (D) Rim volume, pit volume, and inner rim volume. APD = average pit depth, CFT = central foveal thickness; ILM = inner limiting membrane; major = major axis; minor = minor axis.
- Figure 2 ROC curves, exploratory data analysis for selected parameters, and sample fovea
ROC curves for best-performing foveal shape and standard OCT parameters discriminating between (A) NMOSD vs MS, (B) NMOSD ON− vs MS ON−, and (C) NMOSD ON + vs MS ON+. Box and dot plots for (D) pit flat disk area, (E) average pit flat disk diameter, (F) inner rim volume, and (G) major slope disk length, the selected 4 foveal shape parameters. (H) Rim volume and (I) average pit depth, as example foveal shape parameters affected by ON but not diagnosis. A sample central (foveal) B scan of (J) MS ON− and (K) NMOSD ON−, chosen from the median of the selected pit flat disk parameters in each group, demonstrating the difference in foveal pit (pit flat disk), between NMOSD and MS in eyes without a history of ON. AUC = area under the curve; FT = foveal thickness; pRNFL = peripapillary retinal nerve fiber layer thickness; INL = inner nuclear layer volume; HC = healthy controls; MS = patients with MS; NMOSD = patients with neuromyelitis optica spectrum disorders; ON = optic neuritis; ON− = eyes without a history of ON; ON+ = eyes with a history of ON; ROC = receiver operating characteristic.
Tables
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