Regional microglial activation in the substantia nigra is linked with fatigue in MS
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Article Information
- Received March 24, 2020
- Accepted in final form June 18, 2020
- First Published August 7, 2020.
Author Disclosures
- Tarun Singhal, MD,
- Steven Cicero, BS,
- Hong Pan, PhD,
- Kelsey Carter, BS,
- Shipra Dubey, PhD,
- Renxin Chu, PhD,
- Bonnie Glanz, PhD,
- Shelley Hurwitz, PhD,
- Shahamat Tauhid, MD,
- Mi-Ae Park, PhD,
- Marie Kijewski, DSc,
- Emily Stern, MD,
- Rohit Bakshi, MD, MA,
- David Silbersweig, MD and
- Howard L. Weiner, MD
- Tarun Singhal, MD,
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(1) University Neurology Inc. (Non-profit entity), speaker honoraria
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(1) University Neurology Inc. (Non-profit entity)
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Genzyme Sanofi
Department of Defense CMDRP Award# MS180131
Ann Romney Center for Neurologic Diseases
National Multiple Sclerosis SocietyRace to Erase MS FoundationWatercove Charitable Foundation
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- Steven Cicero, BS,
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- Hong Pan, PhD,
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(1) Systems and Methods For Generating Biomarkers Based On Multivariate Classification Of Functional Imaging and Associated Data.(2) System and Method For Z-Shim Compensated Echo-Planar Magnetic Resonance Imaging.(3) Searching System for Biosignature Extraction and Biomarker Discovery.(4) System and Method for Controlling Physiological Noise in Functional Magnetic Resonance Imaging.
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- Kelsey Carter, BS,
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- Shipra Dubey, PhD,
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- Renxin Chu, PhD,
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- Bonnie Glanz, PhD,
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Consortium of Multiple Sclerosis Centers
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- Shelley Hurwitz, PhD,
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(1) Foundation for Neurologic Diseases
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- Shahamat Tauhid, MD,
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Journal of Neuroimaging, Managing Editor, 2015-present
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- Mi-Ae Park, PhD,
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- Marie Kijewski, DSc,
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1. NIH, 5R01HL130563, co-investigator, 2017-20202. NIH, 5R01HL132021, co-investigator, 2017-20203. NIH, 5R01HL131910, co-investigator, 2017-2020
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- Emily Stern, MD,
(1)Spaulding Rehabilitation Hospital- TBI Model Systems SAB (non-profit) Husband:(2) American Foundation for suicide prevention (non-profit)
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(1) National Institute of Heath. Funding for travel for grant review (2) James S. McDonnell Foundation. Funding for travel to speak at conference Husband: (3) Speaker at American Neuropsychiatric Association 2019 Annual Meeting; Husband: Speaker at Tufts Grand Rounds
(1)The International Journal of Imaging Systems and Technology ? Neuroimaging and Brain Mapping, Co-Editor (2011-2017)(2)Journal of Neuroimaging, Editorial Board. (2015-present)Husband: (3) Consulting editor, Journal of Neuropsychiatry and Clinical Neurosciences Editorial Board, Harvard Review of Psychiatry
(1)System and Method for z-Shim Compensated Echo-Planar Magnetic Resonance Imaging, and Systems (issued)(2)System and Methods for Generating Biomarkers Based on Multivariate Classification of Functional Imaging and Associated Data (issued)(3)System and Method for a Multivariate, Automated, Systematic and/or Hierarchical Searching System for Biosignature Extraction and Biomarker Discovery via task-based fMRI Imaging spacetime data (pending)(4)PhyNFI: System and Method for Physiological-Noise-Free Functional Magnetic Resonance Imaging (pending)[All of the above (1-4) apply to both Dr. Stern and her husband, Dr. Silbersweig]
Husband only: (1) Depression in Medical Illness textbook, McGraw Hill 2017
(1) Ceretype Neuromedicine Inc.(2020-present),CEO,unrelated; 1) Brigham and Women?s Hospital, Director Functional Neuroimaging Laboratory, (2008-2020)Husband: (2)Brigham and Women?s Hospital, Chairman Department of Psychiatry, (2008-present)
Husband only: (1) Philips(2) Sanofi(3) Biogen(4) Tilak(5) Goldfinch
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(1) Dr. Stern is the CEO of a startup company, Compass Neurosciences, that will be spinning out of Brigham and Women?s Hospital in the near future. This has not yet occurred, the company presently has no assets, and this activity did not influence what was written in this manuscript; however, it is felt that this is important to disclose. Husband: Co-founder of a company, Compass Neurosciences, the company presently has no assets, and this activity did not influence what was written in this manuscript
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(1) Blackthorn Therapeutics
(1) DHSS Administration for Community Living, formerly the National Institute on Disability and Rehabilitation Research (NIDRR:90DP0039-03-01) Co-PI; PI, BWH Site, (10/1/12- 9/30/18)(2) NIH (NIMH:R01MH110797) Co-investigator, (7/1/17 ? 3/1/19
(1) Baylor College of Medicine
(1)Epilepsy Foundation
(1) Founders shares for Ceretype Neuromedicine, Inc., unrelated.sband: (2)Founders shares for Ceretype Neuromedicine, Inc., no current assets, unrelatedHusband: (3)Founders shares in Buoyant Health, no current assets, unrelated
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- Rohit Bakshi, MD, MA,
Dr. Bakshi has served on advisory boards for (1) Bayer,(2) Biogen, (3) BMS/Celgene, (4) EMD Serono, (5) Genentech, and (6) Novartis.
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Dr. Bakshi serves as Editor-in-Chief of (1) the Journal ofNeuroimaging
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Dr. Bakshi has received consulting fees from (1) EMD Serono.
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Dr. Bakshi has received research support from (1) EMDSerono, (2) Sanofi-Genzyme, and (3) BMS/Celgene.
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Dr. Bakshi has received research support from the (1)Department of Defense (W81XWH-18-1-0648 and W81XWH1910836), (2) National Multiple Sclerosis Society (RR 2005-A-13 and RG-1707-28586), (3) Water Cove foundation, and (4) Race to Erase MS.
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Dr. Bakshi's spouse holds stock in (1) Biogen, Inc.2012-present.
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- David Silbersweig, MD and
american foundation for suicide prevention (non-profit)
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speaker at American Neuropsychiatric Association annual meeting; speaker at Tufts grand rounds
Consulting editor, Journal of Neuropsychiatry and Clinical NeurosciencesEditorial Board, Harvard Review of Psychiatry
(1)System and Method for z-Shim Compensated Echo-Planar Magnetic Resonance Imaging, and Systems (issued)(2)System and Methods for Generating Biomarkers Based on Multivariate Classification of Functional Imaging and Associated Data (issued)(3)System and Method for a Multivariate, Automated, Systematic and/or Hierarchical Searching System for Biosignature Extraction and Biomarker Discovery via task-based fMRI Imaging spacetime data (pending)(4)PhyNFI: System and Method for Physiological-Noise-Free Functional Magnetic Resonance Imaging (pending). [All of the above 1-4 apply to both Dr. Silbersweig and his wife, Dr. Stern]
Depression in Medical Illness textbook, McGraw-Hill, 2017
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BiogenSanofiPhilipsGoldfinchTilak
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founder of a start-up company, not yet with any assets, not related to paper
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wife: contract with blackthorn therapeutics, not related to topic
wife:(1) DHSS Administration for Community Living, formerly the National Institute on Disability and Rehabilitation Research (NIDRR: 90DP0039-03-01) Co-PI; PI, BWH Site, (10/1/12- 9/30/18)(2) NIH (NIMH: R01MH110797) Co-investigator, (7/1/17 ? 3/1/19)
wife: Baylor college of medicine
wife: epilepsy foundation
founders shares in Ceretype Neuromedicine, Inc.,unrelated:founders shares in Buoyant, no current assets, unrelated
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- Howard L. Weiner, MD
served on the advisory board for The Guthy Jackson Charitable Foundation, Teva Pharmaceutical Industries Ltd., Biogen Idec, Novartis, Sanofi-aventis, Tilos Therapeutics, Tiziana Life Sciences, CBridge Capital, IM Therapeutics, Magnolia Therapeutics,Genentech, Genzyme, vTv Therapeutics, MedDay Pharmaceuticals
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Honorarium, travel expenses for University of Colorado talk, ColoradoHonorarium, travel expenses for Istanbul talk, TurkeyHonorarium, travel expenses for McGill University talk, CanadaHonorarium, travel expenses for Mayo Clinic talk, Arizona
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BiodextrisBiogen NovartisSeronoTevaSanofi GenzymeTilos TherapeuticsTiziana Life SciencesvTv TherapeuticsMedDay PharmaceuticalsGenentechCBridge CapitalEverest Medicines LimitedIM TherapeuticsMagnolia TherapeuticsBiogen
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EMD SeronoGoogle Life SciencesVerily Life Sciences
NIH UH3TR000890 - PI - 08/01/13 ? 07/31/18 R01 NS087226 - PI - 09/30/14 ? 07/31/19 R01 EY027921 - PI - 09/01/17 ? 08/31/20
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National Multiple Sclerosis Society
vTv Therapeutics
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- From the Partners MS Center (T.S., S.C., K.C., B.G., R.B., H.L.W.), Ann Romney Center for Neurological Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; PET Imaging Program in Neurologic Diseases (T.S., S.C., K.C.), Ann Romney Center for Neurological Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Functional Neuroimaging Laboratory (H.P., R.B., D.S.), Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Division of Nuclear Medicine and Molecular Imaging (S.D., M.-A.P., M.K.), Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Laboratory for Neuroimaging Research (R.C., S.T.), Ann Romney Center for Neurological Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Medicine (S.H.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Ceretype Neuromedicine (E.S.)Department of Radiology (R.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
- Correspondence
Dr. Singhal tsinghal{at}bwh.harvard.edu
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