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January 2021; 8 (1) Clinical/Scientific NotesOpen Access

LGI1 encephalitis with squamous lung-cell carcinoma: Resolution after tumor resection

Akash Virupakshaiah, Marinos C. Dalakas, Neeja Desai, Scott Mintzer, Jeffrey Ratliff
First published October 9, 2020, DOI: https://doi.org/10.1212/NXI.0000000000000905
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    Figure Immunohistochemical staining of tumor sections for LGI1 (×40)

    Deparaffinized sections from the patient's tumor immunostained with a commercial polyclonal anti-LGI1 antibody, followed by rhodamine-conjugated secondary antibody (A, top) or only with the same secondary antibody omitting the anti-LGI1 serum (B, bottom). Many LGI1-positive cells (red) are identified within the tumor (A); no tumor cells were stained, other than some connective tissue or vessels with the rhodamine-conjugated secondary antibody alone (B). LGI1 = Leucine-rich glioma-inactivated-1.

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